DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and SMC1

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_116647.1	Gene:	SMC1 / 850540	SGDID:	S000001886	Length:	1225	Species:	Saccharomyces cerevisiae

Alignment Length:	1310	Identity:	320/1310 - (24%)
Similarity:	588/1310 - (44%)	Gaps:	207/1310 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIH-------S 153
            |||||.|..::|....:||:|||||||||||::|::.||.|.|:|.:|...:..||:       :
Yeast    11 NFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMDAISFVLGVRSNHLRSNILKDLIYRGVLNDEN 75

  Fly   154 SSSYPNLRSCS---VAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVA 215
            |..|.|..:.|   .:.:.|....||:...|        :.|....:..:.|:|:.|....||.:
Yeast    76 SDDYDNEGAASSNPQSAYVKAFYQKGNKLVE--------LMRIISRNGDTSYKIDGKTVSYKDYS 132

  Fly   216 KLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVD 280
            ..|:..::.::...||:.||:||.||...|       ..:....|::.|:.:|.:..:::.::::
Yeast   133 IFLENENILIKAKNFLVFQGDVEQIAAQSP-------VELSRMFEEVSGSIQYKKEYEELKEKIE 190

  Fly   281 QLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDY---LKKENELVRTKS----FHIQKIISIKKSK 338
            :|:...||.....:....|:|..::..|:..:|   |.|:|||.:.::    :|:::.......|
Yeast   191 KLSKSATESIKNRRRIHGELKTYKEGINKNEEYRKQLDKKNELQKFQALWQLYHLEQQKEELTDK 255

  Fly   339 LEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKK--RLVTVE-- 399
            |.....|..:...::....:.....|.|..::..:|.|:..:.:.:.|.:|::..  ||:.|.
Yeast   256 LSALNSEISSLKGKINNEMKSLQRSKSSFVKESAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQ 320

  Fly   400 ---SAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSKVTL 461
               ...:.|:..:|:..|..::.|..:|:.|.:|:.:.:..|..:.||     |..:....|..|
Yeast   321 AAGKRISHIEKRIESLQKDLQRQKTYVERFETQLKVVTRSKEAFEEEI-----KQSARNYDKFKL 380

  Fly   462 NEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKV---NTAKGEVQV----FESQLKILKQAET 519
            ||.      :| ||...|.||.|.....:  |:||:   |..|.|:|.    |..:..|.|:..|
Yeast   381 NEN------DL-KTYNCLHEKYLTEGGSI--LEEKIAVLNNDKREIQEELERFNKRADISKRRIT 436

  Fly   520 TE-SRKYETLKSSYEQSQKSLEEK----VTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSM 579
            .| |...|.|.:.....:.||.||    ..|:.|||    :::::|.|.:       .:|.:|:.
Yeast   437 EELSITGEKLDTQLNDLRVSLNEKNALHTERLHELK----KLQSDIESAN-------NQEYDLNF 490

  Fly   580 QCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDL-GGIDAKYDIAISTACG 643
            :..:...:|::.|:..:......|:.:.:..:|.  ..||:.|.:.|| .....||.:|:||..|
Yeast   491 KLRETLVKIDDLSANQRETMKERKLRENIAMLKR--FFPGVKGLVHDLCHPKKEKYGLAVSTILG 553

  Fly   644 R-LDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVE- 706
            : .|:::.:|...|...|..||:...|.|:||.||.||...    ..::.|::...:..:..::
Yeast   554 KNFDSVIVENLTVAQECIAFLKKQRAGTASFIPLDTIETEL----PTLSLPDSQDYILSINAIDY 614

  Fly   707 DDRVRTAFYFALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGT 770
            :.....|..:...::::|:.|.....:.:.:. |.::||:.|.:|...|.|:||.|.....:...
Yeast   615 EPEYEKAMQYVCGDSIICNTLNIAKDLKWKKGIRGKLVTIEGALIHKAGLMTGGISGDANNRWDK 679

  Fly   771 QVRTKTAESADSSQISQKALEDMQ----IQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAE 831
            :.........|...|....|.:.|    |:|.|::..|:.......:|..::...|..|..:..|
Yeast   680 EEYQSLMSLKDKLLIQIDELSNGQRSNSIRAREVENSVSLLNSDIANLRTQVTQQKRSLDENRLE 744

  Fly   832 Y--------KRLAVSITSLEQQM------ASNL-KQCEAQRQRMLKKTTDE--RAVKERE----E 875
            .        |.:...||.|::::      ..|| |:.||.:..:.|:.|.:  ..:||.|    |
Yeast   745 IKYHNDLIEKEIQPKITELKKKLDDLENTKDNLVKEKEALQNNIFKEFTSKIGFTIKEYENHSGE 809

  Fly   876 QIEAAKQELEQAQFAEQAVSSQIEEIQN--QYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLN 938
            .:....:||:|.|       .||..::|  |::|   :.:...:.:.:|....:|.....::|
Yeast   810 LMRQQSKELQQLQ-------KQILTVENKLQFET---DRLSTTQRRYEKAQKDLENAQVEMKS-- 862

  Fly   939 VGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEELEK-------EIEESEAS 996
                               |.|...|.|.|:.|:.....:.|...:||:|       |:..||..
Yeast   863 -------------------LEEQEYAIEMKIGSIESKLEEHKNHLDELQKKFVTKQSELNSSEDI 908

  Fly   997 IEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKN-DIPGWQAQLAPLKLNE 1060
            :|...|....:|:|.|.|.::..|.::||:        .|.|..|:.| :||    ..:...:::
Yeast   909 LEDMNSNLQVLKRERDGIKEDIEKFDLERV--------TALKNCKISNINIP----ISSETTIDD 961

  Fly  1061 IP-GETEPQA----------------PLKELNEEELEAETLEALQYKQTMLEEDLKTKKPNLSCI 1108
            :| ..|:.:|                ..||.|.:....|    |:.|...:||.|...:||...:
Yeast   962 LPISSTDNEAITISNSIDINYKGLPKKYKENNTDSARKE----LEQKIHEVEEILNELQPNARAL 1022

  Fly  1109 KEFNEKRLVYLDRVRVL----EDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMIT 1169
            :.::|..    .|..|:    |.:.::..::.:::.:::|:|.:.|...|..::..|..:|:.:|
Yeast  1023 ERYDEAE----GRFEVINNETEQLKAEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELT 1083

  Fly  1170 ---------LGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYY 1225
                     .||:|.|.:.|..:||..|:.:...||.|.:|.:..|||||||:::|||:||::.|
Yeast  1084 KNPNSNVELAGGNASLTIEDEDEPFNAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAINSY 1148

  Fly  1226 KPSPLYFMDEIDAALDFKNVSIVGHYI-KERTKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDS 1289
            :|||.:.:||:|||||..||..:..|| :.|..:.|||::||:..|||.::.|||:|:......|
Yeast  1149 QPSPFFVLDEVDAALDITNVQRIAAYIRRHRNPDLQFIVISLKNTMFEKSDALVGVYRQQQENSS 1213

  Fly  1290 ----ITMLNY 1295
                :.:.||
Yeast  1214 KIITLDLSNY 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	52/159 (33%)
		Smc	89..1281	CDD:224117	316/1290 (24%)
		SMC_hinge	618..733	CDD:214944	29/117 (25%)
		ATP-synt_B	<825..904	CDD:304375	24/101 (24%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	44/98 (45%)
SMC1	NP_116647.1	Smc	3..1225	CDD:224117	320/1310 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810