DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and SMC3

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001190492.1	Gene:	SMC3 / 834917	AraportID:	AT5G48600	Length:	1244	Species:	Arabidopsis thaliana

Alignment Length:	1272	Identity:	500/1272 - (39%)
Similarity:	750/1272 - (58%)	Gaps:	118/1272 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ESTGPRLIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCK 145
            :|..|||.|.::|.|||||||||..:||||:||:|::||||||||||||:|:||||.||.::|..
plant    18 KSGTPRLYIKELVMRNFKSYAGEQRVGPFHKSFSAVVGPNGSGKSNVIDAMLFVFGKRAKQMRLN 82

  Fly   146 RVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQ 210
            :||.|||:|:::.||.|..|:|.|::|:|..:|..|.||.|..:|.|.|..||||.|.||::.:.
plant    83 KVSELIHNSTNHQNLDSAGVSVQFEEIIDLENGLYETVPGSDFMITRVAFRDNSSKYYINERSSN 147

  Fly   211 LKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQI 275
            ..:|.|.||...|||::|||||||||||.|::||||.|..::.|.|||||||:||.:|:..:.::
plant   148 FTEVTKKLKGKGVDLDNNRFLILQGEVEQISLMKPKAQGPHDEGFLEYLEDIIGTNKYVEKIDEL 212

  Fly   276 NQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVR-----TKSFHIQKIISIK 335
            |::::.|.:.|:......||||:|..:||...:||..|:.||...::     ||..:...:..|.
plant   213 NKQLETLNESRSGVVQMVKLAEKERDNLEGLKDEAETYMLKELSHLKWQEKATKMAYEDTVAKIT 277

  Fly   336 KSKLEQYTQEHEACAEELKTHDEGTAALK------QSRAEKETIIRKEI-------EEYEAL-VK 386
            :.:......|:....|.:|. ||....||      :...:::.::..|:       :|:|.. ||
plant   278 EQRDSLQNLENSLKDERVKM-DESNEELKKFESVHEKHKKRQEVLDNELRACKEKFKEFERQDVK 341

  Fly   387 KREQIKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELED----LHKLPE---KNQREI 444
            .||.:|           .::..::....:.:||.::|....||.||    :.||.|   |.|:.:
plant   342 HREDLK-----------HVKQKIKKLEDKLEKDSSKIGDMTKESEDSSNLIPKLQENIPKLQKVL 395

  Fly   445 EDCNKKLESLE-VSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFE 508
            .|..||||.:: ::||    |.|..::||||..|           ||...::.:...:|::.|..
plant   396 LDEEKKLEEIKAIAKV----ETEGYRSELTKIRA-----------ELEPWEKDLIVHRGKLDVAS 445

  Fly   509 SQLKILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEV------ 567
            |:.::|       |:|:|....::..:||.|.:..||..|...:....|.:|..|..|.
plant   446 SESELL-------SKKHEAALKAFTDAQKQLSDISTRKKEKAAATTSWKADIKKKKQEAIEARKV 503

  Fly   568 -DKMVKEERNLSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGID 631
             ::.:||:..|..|....|.::.|..|.|.:::|.|:||..::|.|...:|.||.||:||||.||
plant   504 EEESLKEQETLVPQEQAAREKVAELKSAMNSEKSQNEVLKAVLRAKENNQIEGIYGRMGDLGAID 568

  Fly   632 AKYDIAISTACGRLDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENV 696
            ||||:||||||..||.||.:...:|.|.:..|::.|:|.|||:.|:|...|..:...::.|||:|
plant   569 AKYDVAISTACAGLDYIVVETTSSAQACVELLRKGNLGFATFMILEKQTDHIHKLKEKVKTPEDV 633

  Fly   697 PRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYG--RERYRVVTLRGEMIEMTGTMSGG 759
            |||:|||:|:|:|::.|||.||.||:|..||:|.||||||  ||..|||.|.|.:.|.:||||||
plant   634 PRLFDLVRVKDERMKLAFYAALGNTVVAKDLDQATRIAYGGNREFRRVVALDGALFEKSGTMSGG 698

  Fly   760 GSRPIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKN- 823
            |.:...|:|||.:|        ::.:|.:|:.:.:.:..::...:|..:|:.|:..|:.:..:|
plant   699 GGKARGGRMGTSIR--------ATGVSGEAVANAENELSKIVDMLNNIREKVGNAVRQYRAAENE 755

  Fly   824 --GLQRDEAEYKRLAVSITS----LEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQ 882
              ||:.:.|:.:|...|:.|    ||:|:||    .||..|   .||.:...:||.::.|...::
plant   756 VSGLEMELAKSQREIESLNSEHNYLEKQLAS----LEAASQ---PKTDEIDRLKELKKIISKEEK 813

  Fly   883 ELEQAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRN 947
            |:|..:...:.:..:..|:|...:....|.:|..:||::|:.:.|:|....:...||.:.|..:.
plant   814 EIENLEKGSKQLKDKALELQTNIENAGGEKLKGQKAKVEKIQTDIDKNNTEINRCNVQIETNQKL 878

  Fly   948 ITKIT-GNNNNLRENIKAAEEK------LKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSS 1005
            |.|:| |.....||..:...||      .|.:.:...:.:|..::.::.|:|.:..:.||||...
plant   879 IKKLTKGIEEATREKERLEGEKENLHVTFKDITQKAFEIQETYKKTQQLIDEHKDVLTGAKSDYE 943

  Fly  1006 DIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAP 1070
            ::||.:||:       ...|::.:.|:|....|.|:::....|::.:|..|::.......:.|..
plant   944 NLKKSVDEL-------KASRVDAEFKVQDMKKKYNELEMREKGYKKKLNDLQIAFTKHMEQIQKD 1001

  Fly  1071 LKELNEEELEAETL-----EALQYKQ-----TMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRVL 1125
            |  ::.::|:|..:     ||...|:     .:||..||...|||..|.|:..|..:|..||..|
plant  1002 L--VDPDKLQATLMDNNLNEACDLKRALEMVALLEAQLKELNPNLDSIAEYRSKVELYNGRVDEL 1064

  Fly  1126 EDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVN 1190
            ..:|.:|::.|.:|:|:||||..|||.||:.|:.||||||||||||||||||||||:|||:|||.
plant  1065 NSVTQERDDTRKQYDELRKRRLDEFMAGFNTISLKLKEMYQMITLGGDAELELVDSLDPFSEGVV 1129

  Fly  1191 FTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKER 1255
            |:|||||||||.|:|||||||||||||||||||:|||:|||.|||||||||||||||||||:|:|
plant  1130 FSVRPPKKSWKNIANLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFKNVSIVGHYVKDR 1194

  Fly  1256 TKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDSITM 1292
            ||:|||||:|||.||||||:.||||||..:||.|||:
plant  1195 TKDAQFIIISLRNNMFELADRLVGIYKTDNCTKSITI 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	89/158 (56%)
		Smc	89..1281	CDD:224117	488/1251 (39%)
		SMC_hinge	618..733	CDD:214944	60/114 (53%)
		ATP-synt_B	<825..904	CDD:304375	22/82 (27%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	77/93 (83%)
SMC3	NP_001190492.1	Smc	24..1232	CDD:224117	497/1266 (39%)
		ABC_SMC4_euk	24..>184	CDD:213241	90/159 (57%)
		Csx12	241..>380	CDD:277695	31/150 (21%)
		SMC_hinge	555..670	CDD:214944	60/114 (53%)
		TBPIP	<754..831	CDD:284512	22/83 (27%)
		ABC_SMC4_euk	<1135..1229	CDD:213241	77/93 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	785	1.000	Domainoid score	I8
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4015
Inparanoid	1	1.050	792	1.000	Inparanoid score	I90
OMA	1	1.010	-	-		QHG54018
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	1	1.000	-	-		FOG0003579
OrthoInspector	1	1.000	-	-		oto4193
orthoMCL	1	0.900	-	-		OOG6_101113
Panther	1	1.100	-	-	LDO	PTHR43939
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3446
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840