DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and SMC1A

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_006297.2	Gene:	SMC1A / 8243	HGNCID:	11111	Length:	1233	Species:	Homo sapiens

Alignment Length:	1321	Identity:	350/1321 - (26%)
Similarity:	612/1321 - (46%)	Gaps:	219/1321 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHSSS-SYPN 159
            |||||.|...:||| |.||||||||||||||::|::.||.|.:.:.:|.|.:..|||.:. ..|.
Human    11 NFKSYKGRQIIGPF-QRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGAPVGKPA 74

  Fly   160 LRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKLLKKHHVD 224
            .....|::.:.:     :| .||...:.:::      ..||.|:||:|..||.:.::.|:|..:.
Human    75 ANRAFVSMVYSE-----EG-AEDRTFARVIV------GGSSEYKINNKVVQLHEYSEELEKLGIL 127

  Fly   225 LEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQLTDDRTEK 289
            ::...||:.||.||||||..||.:|       ...|:|..:....:...:..:.:.:..:|....
Human   128 IKARNFLVFQGAVESIAMKNPKERT-------ALFEEISRSGELAQEYDKRKKEMVKAEEDTQFN 185

  Fly   290 HNRCKLAEREMKDLEQPFNEAVDYLKKENELVRT-------KSFH-------IQKIISIKKSKLE 340
            ::|.|....|.|:.:|...||..|.:.::|:||.       |.:|       :.|.::.|..::|
Human   186 YHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIE 250

  Fly   341 QYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEA--------LVKKREQIKKRLVT 397
            :..:..:...:|||...:...  |..|.:::  |.|||:|.::        .:|.:|....::..
Human   251 KDKKRMDKVEDELKEKKKELG--KMMREQQQ--IEKEIKEKDSELNQKRPQYIKAKENTSHKIKK 311

  Fly   398 VESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHK--------LPEKNQREIEDCN------ 448
            :|:|    :.:::|..|..||.|..:::.|||:..:.|        :.|::|.:..|..
Human   312 LEAA----KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQV 372

  Fly   449 KKLESL--EVSK--VTLNEELEK----QQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQ 505
            ||...|  |.||  .||.:||||    |:|:         :.||.|.:     ::||.|
Human   373 KKYHRLKEEASKRAATLAQELEKFNRDQKAD---------QDRLDLEE-----RKKVET------ 417

  Fly   506 VFESQLK-ILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDK 569
              |:::| .|::.|..:.| .|.|:.....|::||||:.....||.|.:     |:|.:  .:|:
Human   418 --EAKIKQKLREIEENQKR-IEKLEEYITTSKQSLEEQKKLEGELTEEV-----EMAKR--RIDE 472

  Fly   570 MVKEERNLSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPG-ILGRLGDL-GGIDA 632
            :.||...:..|....|.:..|.|    .|:...::::.:.|:     .|| :.|||.|| .....
Human   473 INKELNQVMEQLGDARIDRQESS----RQQRKAEIMESIKRL-----YPGSVYGRLIDLCQPTQK 528

  Fly   633 KYDIAISTACGR-LDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENV 696
            ||.||::...|: :|.|:.|:.:|....|..:||......||:.||.:|  .:..:.::...:..
Human   529 KYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLE--VKPTDEKLRELKGA 591

  Fly   697 PRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAY-GRERYRVVTLRGEMIEMTGTMSGGG 760
            ..:.|:::.|...::.|..:|..|.||||::|...|||: |.:|::.|.|.|.:.:.:|.:|||.
Human   592 KLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGA 656

  Fly   761 S------RPIRGKMGTQVRTKTAESADSSQISQKA------LEDMQIQAEELQARVNYCQ----- 808
            |      |....|...:::.|.....:..:...||      |..:|.||..||.|:.|.|
Human   657 SDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQ 721

  Fly   809 ----------EQQGSLERE-------IQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQ 856
                      :::..||.|       |..:|..:|..|.|.|.|...:..:|.::....  |...
Human   722 TKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF--CREI 784

  Fly   857 RQRMLKKTTDERAVKEREEQIEAAKQELE-QAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKI 920
            ..|.:::..:|:.    :.|.|.||:.|| :.|.....:....|:.|.:.|   .:.|...|..:
Human   785 GVRNIREFEEEKV----KRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKED---QDKVHMWEQTV 842

  Fly   921 KKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEE 985
            ||..::||||                        ....:.::|..:|.:..|.:.:|:...||.|
Human   843 KKDENEIEKL------------------------KKEEQRHMKIIDETMAQLQDLKNQHLAKKSE 883

  Fly   986 L---EKEIEESEASIEGAKSQSSDIKKEIDEI-TKEENKRNIERIEI-------DTKLQAAAGKM 1039
            :   ..|:||....:.||..:.:.::||:..| ||.|.||: :|..:       |.||..:.|.|
Human   884 VNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRS-DRHNLLQACKMQDIKLPLSKGTM 947

  Fly  1040 NKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLK----ELNEEELEAETLEALQYKQTMLEEDLKT 1100
            :.:..:....|.:.:......|......:|.::    :|.|:..:|:..|.::.:...|::.|..
Human   948 DDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNE 1012

  Fly  1101 KKPNLSCIKEFNEKRLVYLDRVR--------VLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSII 1157
            ::..|..|...|.|.:..|:.||        ..|....:..:.:..:|:::|.|:..|...|..:
Human  1013 QQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESV 1077

  Fly  1158 TRKLKEMYQMITLGGDAELEL--VDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVF 1220
            ...:.|:|:.::....|:..|  .:..:|:.:|:|:....|.|.::.:.||||||||:::|||:|
Human  1078 ATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLF 1142

  Fly  1221 ALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKER-TKNAQFIIVSLRVNMFELANFLVGIY-KV 1283
            |:|.|||:|.:.:||||||||..|:..|.:||||: |.|.|.|::||:...:..|..|:|:| :.
Human  1143 AIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQ 1207

  Fly  1284 SDCTDS----ITMLNYPPTLP 1300
            .||..|    ..:..||...|
Human  1208 GDCVISKVLTFDLTKYPDANP 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	58/150 (39%)
		Smc	89..1281	CDD:224117	343/1295 (26%)
		SMC_hinge	618..733	CDD:214944	34/117 (29%)
		ATP-synt_B	<825..904	CDD:304375	18/79 (23%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	47/99 (47%)
SMC1A	NP_006297.2	SMC_N	3..1210	CDD:308206	344/1301 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..308		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..369		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..966		2/18 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820