Protein Alignment glu and SMC6

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_011531409.1
• Gene: SMC6 / 79677
• HGNCID: 20466
• Length: 1110
• Species: Homo sapiens
• Alignment Length: 1383
• Identity: 279/1383 - (20%)
• Similarity: 523/1383 - (37%)
• Gaps: 389/1383 - (28%)

  Fly    18 RQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTRIGDIYIPPPVPPHCSMES 82
            |:...|..|     :..:..:|:|.||...|.      .:||..||.:             :...
Human     4 RKEENFSSP-----KNAKRPRQEELEDFDKDG------DEDECKGTTL-------------TAAE 44

  Fly    83 TGPRLIISKIVNRNFKSYAGEVELGPFH--QSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCK 145
            .|   ||..|..:||..::   .||||.  .:...::|.||||||.|:.:::...|.||  :...
Human    45 VG---IIESIHLKNFMCHS---MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRA--VATN 101

  Fly   146 RVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCE-DVPDSSIVIERTAMSDNSSYYQINDKRA 209
            |.|:|........|....|:.:.     ::||...: .|..:||:|::....|.|..|::.....
Human   102 RGSSLKGFVKDGQNSADISITLR-----NRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATG 161

  Fly   210 QL-----KDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEY------LEDIV 263
            .:     :::..:|...::.:: |...:|..|     |.|...|::||....::      ||.:.
Human   162 SVVSTRKEELIAILDHFNIQVD-NPVSVLTQE-----MSKQFLQSKNEGDKYKFFMKATQLEQMK 220

  Fly   264 GTQRYI-----RPLQQINQRVDQLTDDR---TEKHNRC------------------KLAEREMKD 302
            ....||     |..:||:|..::||:.:   .||..|.                  ::|...:.:
Human   221 EDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNE 285

  Fly   303 LEQPFNEAVDYL------------KKENELVRTKSFHIQKIISIKKSKLEQYTQEHEACAEELKT 355
            :|:..|...|.:            |.|.:.||..... ||...| :.|||:.::|..|.|.|...
Human   286 IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAE-QKYKDI-QDKLEKISEETNARAPECMA 348

  Fly   356 HDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKDK 420
            ......|.|::..|.|.:..:.:.||:||.|..||:.||:                  ::.||
Human   349 LKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRI------------------EELKK-- 393

  Fly   421 AQIEKNEKELEDLHKLPEK--NQREIEDCNKKLESLEVSKVTLNEELEKQQAELTKTTAPLTEKR 483
                ..::.||     ||:  .|::|....:::::.:..:.::|:|:|:.|..:.|.    .|:.
Human   394 ----STDQSLE-----PERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKD----KEEH 445

  Fly   484 LKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAETTESRKY--------ETLKSSYEQSQKSLE 540
            .|:..|.:.:|..::       ..:.|||.||.::|...:::        |.:..:|.|...:.:
Human   446 GKIKREELDVKHALS-------YNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503

  Fly   541 EKVTRVDELKESIPRMKTEIASKSAEVDKMVK------------EERNLSMQCNKLRTEINERSS 593
            .    |..|...|.....|:|   ..::..:|            :||.|.....:.......|..
Human   504 P----VGPLGACIHLRDPELA---LAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPP 561

  Fly   594 VMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVTDN------ 652
            ::.:: ..|::.|...|.......|.:|..|                   .:||.|..|
Human   562 IIVSE-FRNEIYDVRHRAAYHPDFPTVLTAL-------------------EIDNAVVANSLIDMR 606

  Fly   653 -YETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYF 716
             .||    :..:|..:|.||.      ::..:...|.|           :....:.|:|....|:
Human   607 GIET----VLLIKNNSVARAV------MQSQKPPKNCR-----------EAFTADGDQVFAGRYY 650

  Fly   717 ALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAESAD 781
            :..||                                                   |.|......
Human   651 SSENT---------------------------------------------------RPKFLSRDV 664

  Fly   782 SSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQM 846
            .|:||     |::.:.|...|::...|:...:||::|:..:..|:|.:..||.|.:.|    ::.
Human   665 DSEIS-----DLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKI----RKN 720

  Fly   847 ASNLKQCE-AQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRN 910
            .|.:::.| .:..:.:...|.|...:|.:.:::..::.:||.:...:.:.|...|.:|:||.::
Human   721 ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIK- 784

  Fly   911 ESVKPVEAKIKKVNSQIEKLAANVR-SLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNE 974
                      .|:| |:.:||..:: .||:    ||..:       :|.:...:..|||.|...:
Human   785 ----------FKIN-QLSELADPLKDELNL----ADSEV-------DNQKRGKRHYEEKQKEHLD 827

  Fly   975 DRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNI--ERIEIDTKLQAAAG 1037
            ..||.|.:.:..|||:||                       |....|.|  ||||::........
Human   828 TLNKKKRELDMKEKELEE-----------------------KMSQARQICPERIEVEKSASILDK 869

  Fly  1038 KMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKK 1102
            ::|:::..|   ||:.|                 ...:.||:..:..||   ::|.|:.|.|.:
Human   870 EINRLRQKI---QAEHA-----------------SHGDREEIMRQYQEA---RETYLDLDSKVR- 910

  Fly  1103 PNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQM 1167
                .:|:|          :::|.:|...|.:   .|::.|..|.|...:.:..|     .::||
Human   911 ----TLKKF----------IKLLGEIMEHRFK---TYQQFRSFRQKNKPNLYYYI-----NLFQM 953

  Fly  1168 --ITLGGDAELELVDSMDPFTEGVNF---------TVRP---PKKSWKYISNLSGGEKTLSSLAL 1218
              :||......:.:.|...:...:||         :|:|   .|.::..:..|||||::.|::..
Human   954 QCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCF 1018

  Fly  1219 VFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYI---KERTKNAQFIIVSLRVNMFEL-ANFLVG 1279
            :.:|.....||...:||.|..:|..|..|....|   .:..:..|||:::.: :|..| ::.|:.
Human  1019 ILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQ-SMSSLPSSKLIR 1082

  Fly  1280 IYKVSDCTDSITMLNYPP 1297
            |.::||.....|.|.:.|
Human  1083 ILRMSDPERGQTTLPFRP 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	262/1300 (20%)
SMC6	XP_011531409.1	P-loop containing Nucleoside Triphosphate Hydrolases	48..>204	CDD:476819	41/171 (24%)
		SMC_prok_B	<215..>900	CDD:274008	171/903 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<996..1094	CDD:476819	26/98 (27%)