DRSC/TRiP Functional Genomics Resources

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Protein Alignment glu and SMC6

DIOPT Version :9

Sequence 1:NP_723996.1 Gene:glu / 35001 FlyBaseID:FBgn0015391 Length:1409 Species:Drosophila melanogaster
Sequence 2:XP_011531409.1 Gene:SMC6 / 79677 HGNCID:20466 Length:1110 Species:Homo sapiens


Alignment Length:1383 Identity:279/1383 - (20%)
Similarity:523/1383 - (37%) Gaps:389/1383 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 RQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTRIGDIYIPPPVPPHCSMES 82
            |:...|..|     :..:..:|:|.||...|.      .:||..||.:             :...
Human     4 RKEENFSSP-----KNAKRPRQEELEDFDKDG------DEDECKGTTL-------------TAAE 44

  Fly    83 TGPRLIISKIVNRNFKSYAGEVELGPFH--QSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCK 145
            .|   ||..|..:||..::   .||||.  .:...::|.||||||.|:.:::...|.||  :...
Human    45 VG---IIESIHLKNFMCHS---MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRA--VATN 101

  Fly   146 RVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCE-DVPDSSIVIERTAMSDNSSYYQINDKRA 209
            |.|:|........|....|:.:.     ::||...: .|..:||:|::....|.|..|::.....
Human   102 RGSSLKGFVKDGQNSADISITLR-----NRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATG 161

  Fly   210 QL-----KDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEY------LEDIV 263
            .:     :::..:|...::.:: |...:|..|     |.|...|::||....::      ||.:.
Human   162 SVVSTRKEELIAILDHFNIQVD-NPVSVLTQE-----MSKQFLQSKNEGDKYKFFMKATQLEQMK 220

  Fly   264 GTQRYI-----RPLQQINQRVDQLTDDR---TEKHNRC------------------KLAEREMKD 302
            ....||     |..:||:|..::||:.:   .||..|.                  ::|...:.:
Human   221 EDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNE 285

  Fly   303 LEQPFNEAVDYL------------KKENELVRTKSFHIQKIISIKKSKLEQYTQEHEACAEELKT 355
            :|:..|...|.:            |.|.:.||..... ||...| :.|||:.::|..|.|.|...
Human   286 IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAE-QKYKDI-QDKLEKISEETNARAPECMA 348

  Fly   356 HDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKDK 420
            ......|.|::..|.|.:..:.:.||:||.|..||:.||:                  ::.||  
Human   349 LKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRI------------------EELKK-- 393

  Fly   421 AQIEKNEKELEDLHKLPEK--NQREIEDCNKKLESLEVSKVTLNEELEKQQAELTKTTAPLTEKR 483
                ..::.||     ||:  .|::|....:::::.:..:.::|:|:|:.|..:.|.    .|:.
Human   394 ----STDQSLE-----PERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKD----KEEH 445

  Fly   484 LKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAETTESRKY--------ETLKSSYEQSQKSLE 540
            .|:..|.:.:|..::       ..:.|||.||.::|...:::        |.:..:|.|...:.:
Human   446 GKIKREELDVKHALS-------YNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503

  Fly   541 EKVTRVDELKESIPRMKTEIASKSAEVDKMVK------------EERNLSMQCNKLRTEINERSS 593
            .    |..|...|.....|:|   ..::..:|            :||.|.....:.......|..
Human   504 P----VGPLGACIHLRDPELA---LAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPP 561

  Fly   594 VMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVTDN------ 652
            ::.:: ..|::.|...|.......|.:|..|                   .:||.|..|      
Human   562 IIVSE-FRNEIYDVRHRAAYHPDFPTVLTAL-------------------EIDNAVVANSLIDMR 606

  Fly   653 -YETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYF 716
             .||    :..:|..:|.||.      ::..:...|.|           :....:.|:|....|:
Human   607 GIET----VLLIKNNSVARAV------MQSQKPPKNCR-----------EAFTADGDQVFAGRYY 650

  Fly   717 ALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAESAD 781
            :..||                                                   |.|......
Human   651 SSENT---------------------------------------------------RPKFLSRDV 664

  Fly   782 SSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQM 846
            .|:||     |::.:.|...|::...|:...:||::|:..:..|:|.:..||.|.:.|    ::.
Human   665 DSEIS-----DLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKI----RKN 720

  Fly   847 ASNLKQCE-AQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRN 910
            .|.:::.| .:..:.:...|.|...:|.:.:::..::.:||.:...:.:.|...|.:|:||.:: 
Human   721 ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIK- 784

  Fly   911 ESVKPVEAKIKKVNSQIEKLAANVR-SLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNE 974
                      .|:| |:.:||..:: .||:    ||..:       :|.:...:..|||.|...:
Human   785 ----------FKIN-QLSELADPLKDELNL----ADSEV-------DNQKRGKRHYEEKQKEHLD 827

  Fly   975 DRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNI--ERIEIDTKLQAAAG 1037
            ..||.|.:.:..|||:||                       |....|.|  ||||::........
Human   828 TLNKKKRELDMKEKELEE-----------------------KMSQARQICPERIEVEKSASILDK 869

  Fly  1038 KMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKK 1102
            ::|:::..|   ||:.|                 ...:.||:..:..||   ::|.|:.|.|.: 
Human   870 EINRLRQKI---QAEHA-----------------SHGDREEIMRQYQEA---RETYLDLDSKVR- 910

  Fly  1103 PNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQM 1167
                .:|:|          :::|.:|...|.:   .|::.|..|.|...:.:..|     .::||
Human   911 ----TLKKF----------IKLLGEIMEHRFK---TYQQFRSFRQKNKPNLYYYI-----NLFQM 953

  Fly  1168 --ITLGGDAELELVDSMDPFTEGVNF---------TVRP---PKKSWKYISNLSGGEKTLSSLAL 1218
              :||......:.:.|...:...:||         :|:|   .|.::..:..|||||::.|::..
Human   954 QCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCF 1018

  Fly  1219 VFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYI---KERTKNAQFIIVSLRVNMFEL-ANFLVG 1279
            :.:|.....||...:||.|..:|..|..|....|   .:..:..|||:::.: :|..| ::.|:.
Human  1019 ILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQ-SMSSLPSSKLIR 1082

  Fly  1280 IYKVSDCTDSITMLNYPP 1297
            |.::||.....|.|.:.|
Human  1083 ILRMSDPERGQTTLPFRP 1100

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gluNP_723996.1 ABC_SMC4_euk 87..>246 CDD:213241 40/166 (24%)
Smc 89..1281 CDD:224117 259/1294 (20%)
SMC_hinge 618..733 CDD:214944 20/121 (17%)
ATP-synt_B <825..904 CDD:304375 15/79 (19%)
ABC_SMC4_euk <1196..1290 CDD:213241 26/97 (27%)
SMC6XP_011531409.1 Smc 48..1088 CDD:224117 260/1298 (20%)
ABC_SMC6_euk 48..>204 CDD:213243 41/171 (24%)
Fib_alpha <662..742 CDD:285864 19/88 (22%)
DUF5098 701..>835 CDD:293628 35/160 (22%)
ABC_SMC6_euk <996..1094 CDD:213243 26/98 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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