DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and Smc4

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_598547.1	Gene:	Smc4 / 70099	MGIID:	1917349	Length:	1286	Species:	Mus musculus

Alignment Length:	1301	Identity:	520/1301 - (39%)
Similarity:	794/1301 - (61%)	Gaps:	45/1301 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RPS------KGTPKAAGGARQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGT 63
            :||      :|.|.:..||....:...|...|:....|:...||.|..  :|::.|
Mouse     7 KPSTACHQEEGPPPSQDGAHSDEEMEQPAGEAESAAPAKPPGEELDNR--SLEEIL--------- 60

  Fly    64 RIGDIYIPPPVPPHCSMESTGPRLIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVI 128
                ..||||.||..:.|:..|||:|:.|||:||||||||..|||||:.|:.|||||||||||||
Mouse    61 ----NSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVI 121

  Fly   129 DSMMFVFGCRANRIRCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERT 193
            |||:||||.||.:||.|::|.|||:|..:.:::||:|.|||::|:||.....|.:|:|:..:.||
Mouse   122 DSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVLPNSNFYVSRT 186

  Fly   194 AMSDNSSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEY 258
            |..|::|.|.|:.|:...|||..||:.|.:||:||||||||||||.|||||||||||::.|||||
Mouse   187 AYRDSTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEY 251

  Fly   259 LEDIVGTQRYIRPLQQINQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRT 323
            ||||:|..|...|::.:.:||:.|.:.|.||.||.|:.|:|...||...|.|:::|..|||:.:.
Mouse   252 LEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEMFKK 316

  Fly   324 KSFHIQKIISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKR 388
            |:...|..|...::::.:.|.:.|...|:.|...|.:..|......|.:.::...::...:.|..
Mouse   317 KNHICQYYIYDLQNRIAEITTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDVEKKLNKVTKFI 381

  Fly   389 EQIKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLES 453
            ||.|::...::....:::..:::...:.||.:.|::|:::::|:|..:|.|::..|.:...:..|
Mouse   382 EQNKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSVPAKSKTVINETTTRNNS 446

  Fly   454 LEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAE 518
            ||..:....::|::....|.:.|..|.:::.....||:|..:.||.|:.:::|.:|:|.|.....
Mouse   447 LEKEREKEEKKLKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRH 511

  Fly   519 TTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNK 583
            .|...:....|.:...:.::|:|:...:.::...:|:.:.|:..|..|:.|:.:||.||....:.
Mouse   512 NTAVSQLSKAKEALITASETLKERKAAIKDINTKLPQTQQELKEKEKELQKLTQEEINLKSLVHD 576

  Fly   584 LRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNI 648
            |..::.|..|.:...||..||||.:::.|..|:||||.|||||||.||.|||||||:.|..||.|
Mouse   577 LFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYI 641

  Fly   649 VTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTA 713
            |.|:.:||...:..||::|:|.||||.|||:....::. |:|.||||.|||:|||||:::.:|.|
Mouse   642 VVDSIDTAQECVNFLKKHNIGIATFIGLDKMTVWAKKM-SKIQTPENTPRLFDLVKVKNEEIRQA 705

  Fly   714 FYFALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTA 777
            ||||||:|||.::|:|.||:||.|: |:|||||:|::||.:||||||||:.:||:||:.|
Mouse   706 FYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMSGGGSKVMRGRMGSSV----- 765

  Fly   778 ESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSL 842
                ..:||.:.:..|:.|.|....:....|||:...|..:..|::..:......::.|.||..|
Mouse   766 ----IDEISVEEVNKMESQLERHSKQAMQIQEQKVQHEEAVVKLRHSERDMRNTLEKFAASIQGL 826

  Fly   843 EQQ---MASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQA--VSSQIEEIQ 902
            .:|   :...:|:.||   .:|....|.:..|..||.:...|:|.:..  ||:|  |.::|:.:.
Mouse   827 SEQEEYLCVQIKELEA---NVLTTAPDRKQQKLLEENVSVFKKEYDAV--AEKAGKVEAEIKRLH 886

  Fly   903 NQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEE 967
            |....:.|..:|..:.|:..:|.|:::.|:.:....|.:.|||||:.|...:.....:.||..|:
Mouse   887 NTIIDINNRKLKAQQNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEKEIKDTEK 951

  Fly   968 KLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKL 1032
            ::..|..:....::|.||:....:.:|.|:...:.:..::.:|:..|.:.|:....:.:.|..||
Mouse   952 EINDLKTELKNIEDKAEEVINNTKTAETSLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKL 1016

  Fly  1033 QAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEA-ETLEALQYKQTMLEE 1096
            :...|.:::..:.|..||.:::.:||:  |.|..|...:..|::||||| :..|::..:..:||.
Mouse  1017 EQIDGHISEHNSKIKYWQKEISKIKLH--PVEDNPVETVAVLSQEELEAIKNPESITNEIALLEA 1079

  Fly  1097 DLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKL 1161
            ..:..||||..|.|:.:|..:||.||..|:.|||:|:..|..||::||:|..|||.||.:||.||
Mouse  1080 QCREMKPNLGAIAEYKKKEDLYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKL 1144

  Fly  1162 KEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYK 1226
            ||.|||:|||||||||||||:|||:||:.|:|||||||||.|.|||||||||||||||||||:||
Mouse  1145 KENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYK 1209

  Fly  1227 PSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDSIT 1291
            |:||||||||||||||||||||..||.|:||||||||:|||.||||:::.|:||||..:.|.|:.
Mouse  1210 PTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNSTKSVA 1274

  Fly  1292 M 1292
            :
Mouse  1275 V 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	94/158 (59%)
		Smc	89..1281	CDD:224117	491/1198 (41%)
		SMC_hinge	618..733	CDD:214944	66/114 (58%)
		ATP-synt_B	<825..904	CDD:304375	20/83 (24%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	73/93 (78%)
Smc4	NP_598547.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		10/43 (23%)
Smc4	NP_598547.1	SMC_N	81..1272	CDD:308206	495/1207 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846724
Domainoid	1	1.000	893	1.000	Domainoid score	I51
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4015
Inparanoid	1	1.050	924	1.000	Inparanoid score	I353
Isobase	1	0.950	-	0	Normalized mean entropy	S1360
OMA	1	1.010	-	-		QHG54018
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003579
OrthoInspector	1	1.000	-	-		oto94977
orthoMCL	1	0.900	-	-		OOG6_101113
Panther	1	1.100	-	-	LDO	PTHR43939
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3446
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.710