DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment glu and Smc6

DIOPT Version :9

Sequence 1:NP_723996.1 Gene:glu / 35001 FlyBaseID:FBgn0015391 Length:1409 Species:Drosophila melanogaster
Sequence 2:NP_079971.2 Gene:Smc6 / 67241 MGIID:1914491 Length:1097 Species:Mus musculus


Alignment Length:1367 Identity:267/1367 - (19%)
Similarity:519/1367 - (37%) Gaps:393/1367 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 QQLRAQQQQEEEDAAVDALDDALIFDDEEGGTRIGDIYIPPPVPPHCSMESTGPRLIISKIVNRN 96
            :..:..:|:|.||...|..:|........|.:.:             :....|   ||..|..||
Mouse    13 ENAKRPRQEELEDFDKDGDEDECTISFTNGTSTL-------------TAAEVG---IIESIQLRN 61

  Fly    97 FKSYAGEVELGPFH--QSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHSSSSYPN 159
            |..::   .||||.  .:...::|.||||||.|:.:::...|.:|  :...|.|:|.....:..|
Mouse    62 FMCHS---MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKA--VATNRGSSLKGFVKAGQN 121

  Fly   160 LRSCSVAVHFKQIVDKGDGTCE-DVPDSSIVIERTAMSDNSSYYQINDKRAQL-----KDVAKLL 218
            ....|:.:.     ::||.... :|...|||:::....|.|..|::..::..:     :::..:|
Mouse   122 SADISITLR-----NRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAIL 181

  Fly   219 KKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEY------LEDIVGTQRYI-----RPL 272
            ...::.:: |...:|..|     |.|...|::||....::      ||.:.....||     |..
Mouse   182 DHFNIQVD-NPVSVLTQE-----MSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTK 240

  Fly   273 QQINQRVDQLTDDR---TEKHNRC------------------KLAEREMKDLEQPFNEAVDYL-- 314
            :||||..::||:.:   .||..|.                  ::|...:.::|:..|...|.:  
Mouse   241 EQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKI 305

  Fly   315 ----------KKENELVRTKSFHIQKIISIKKSKLEQYTQEHEACAEE---LKTHDEGTAALKQS 366
                      |.|.:.||...  .:|.....:.|||:.::|..|.|.|   |||.     .:.::
Mouse   306 GEERAAKLDRKMEEQQVRLND--AEKKYKDIQDKLEKISEETNARAPECMALKTD-----VIART 363

  Fly   367 RA--EKETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKE 429
            ||  :.|.:..:.:.||:||.|..||:.||:                  ::.||      ..::.
Mouse   364 RAFNDAEVLYNRSLNEYKALKKDGEQLCKRI------------------EELKK------STDQS 404

  Fly   430 LEDLHKLPEKNQREIEDC--NKKLESLEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVG 492
            ||     ||:.:|:...|  .:|:::|:..:.|:|:|.|:.:..:.|.    .::..::..|.:.
Mouse   405 LE-----PERLERQKRICWLKEKVKALQDQEHTVNQEAEQFEQAIEKD----KQEHGRVRKEDIE 460

  Fly   493 LKEKVNTAKGEVQVFESQLKILKQAETTESRKY--------ETLKSSYEQSQKSLEEKVTRVDEL 549
            ::..:|       ..:.|||.||.::|...:::        |.:..:|.:.|.:.:.    :..|
Mouse   461 VRHALN-------YNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKP----IGPL 514

  Fly   550 KESIPRMKTEIASKSAEVDKMVK------------EERNLSMQCNKLRTEINERSSVMQAQRSNN 602
            ...|.....|:|   ..::..:|            :||.|.....|.......|..::.:: ..:
Mouse   515 GACIHLRDPELA---LAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRPQIIVSE-FRD 575

  Fly   603 KVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVTDN-------YETASAAI 660
            :|.|..:|.....:.|.:|..|                   .:||.|..|       .||    :
Mouse   576 EVYDVRLRAAYHPEFPTVLTAL-------------------EIDNAVVANSLIDMRSIET----V 617

  Fly   661 GALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYFALRNTLVCD 725
            ..:|..:|.||.      ::..:...|.|           :....:.|:|....|::..:|    
Mouse   618 LLIKNNSVARAV------MQSQKPPKNCR-----------EAFTADGDQVFAGRYYSSEST---- 661

  Fly   726 DLEQGTRIAYGRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAESADSSQISQKAL 790
                                                           |.|.......|:||    
Mouse   662 -----------------------------------------------RPKFLSRDVDSEIS---- 675

  Fly   791 EDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCE- 854
             |::.:.|..:..:...|::..:||::|:..:..|:|.:..||.:.:.|    ::..|.:::.| 
Mouse   676 -DLETEIENKKGHIITLQQRLSALEKDIKRNEELLKRCQLHYKEIKMKI----RKNISEIRELEN 735

  Fly   855 AQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAK 919
            .:..:.:...|.|...:|.:.:::..::.:||.:...:.:.|...|.:|:|||::          
Mouse   736 IEEHQSVDIATLEDEAEENKIKMQMVEKNMEQQKENMENLKSLKIEAENKYDTIK---------- 790

  Fly   920 IKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKE 984
             .|:| |:.:||                        :.|::.:..|:.::.|    :.:.|:..|
Mouse   791 -LKIN-QLSELA------------------------DPLKDELNLADSEVDS----QKRGKQHYE 825

  Fly   985 ELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGW 1049
            :.:||                    .:|.:.|       :|.|:|.|.:....||::.:      
Mouse   826 DKQKE--------------------HLDTLNK-------KRRELDMKEKELQEKMSQAR------ 857

  Fly  1050 QAQLAPLKLNEIPGETEPQAPL--KELN--EEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKE 1110
              |:.|.::     |.:..|.:  ||:|  .::::||.......::.|               |:
Mouse   858 --QICPERI-----EVKKSASILDKEINRLRQKIQAEHASHGDREEIM---------------KQ 900

  Fly  1111 FNEKRLVYLD---RVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGG 1172
            :.|.|..|||   :||.|.....       ..||:...|||.:......:|.:.| :|....|..
Mouse   901 YQEARETYLDLDNKVRTLRRFIK-------LLEEIMTHRYKTYQQFRRCLTLRCK-LYFDNLLSQ 957

  Fly  1173 DAELELVDSMDPFTEGVNFTVRP---PKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMD 1234
            .|....: :.|...|.::.||:|   .|.|:..:..|||||::.|::..:.:|.....||...:|
Mouse   958 RAYCGKM-NFDHKNETLSITVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLD 1021

  Fly  1235 EIDAALDFKNVSIVGHYI---KERTKNAQFIIVSLRVNMFEL-ANFLVGIYKVSDCTDSITMLNY 1295
            |.|..:|..|..|....|   .:..:..|||:::.: :|..| ::.|:.|.::||.....|.|.:
Mouse  1022 EFDVYMDMVNRRIAMDMILKMADSQRFRQFILLTPQ-SMSSLPSSKLIRILRMSDPERGQTTLPF 1085

  Fly  1296 PP 1297
            .|
Mouse  1086 RP 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gluNP_723996.1 ABC_SMC4_euk 87..>246 CDD:213241 40/166 (24%)
Smc 89..1281 CDD:224117 252/1292 (20%)
SMC_hinge 618..733 CDD:214944 19/121 (16%)
ATP-synt_B <825..904 CDD:304375 14/79 (18%)
ABC_SMC4_euk <1196..1290 CDD:213241 27/97 (28%)
Smc6NP_079971.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 5/18 (28%)
Smc 54..1075 CDD:224117 253/1296 (20%)
ABC_SMC6_euk 54..>210 CDD:213243 41/171 (24%)
Flexible hinge 458..667 44/314 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 813..839 7/56 (13%)
ABC_SMC6_euk <983..1081 CDD:213243 27/98 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1097 3/10 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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