DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and smc1a

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001155103.1	Gene:	smc1a / 559665	ZFINID:	ZDB-GENE-090506-9	Length:	1232	Species:	Danio rerio

Alignment Length:	1309	Identity:	337/1309 - (25%)
Similarity:	616/1309 - (47%)	Gaps:	195/1309 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHSSS-SYPN 159
            |||||.|...:||||: ||||||||||||||::|::.||...:.:.:|.|.:..|||.:. ..|.
Zfish    11 NFKSYKGRQIIGPFHK-FTAIIGPNGSGKSNLMDAISFVLAEKTSNLRVKTLKDLIHGAPVGKPA 74

  Fly   160 LRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKLLKKHHVD 224
            .....|::.:          |||..:......  |:..:||.|:||.|...|.|.::.|:|..:.
Zfish    75 ANRAFVSMVY----------CEDNGEECTFTR--AIIGSSSEYRINSKVVGLSDYSEELEKLGIL 127

  Fly   225 LEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQLTDDRTEK 289
            ::...||:.||.||||||..||.:|       ...|:|..:....:...:..:.:.:..:|....
Zfish   128 IKARNFLVFQGAVESIAMKNPKERT-------ALFEEISRSGELAQEYDRRKKEMVKAEEDTQFS 185

  Fly   290 HNRCKLAEREMKDLEQPFNEAVDYLKKENELVRT-------KSFHIQKIISIKKSKLEQYTQEHE 347
            ::|.|....|.|:.:|...||..|.:.::|:||.       |.:|.::.|.....:|.|..:|.:
Zfish   186 YHRKKNIAAERKEAKQEKEEAERYQRLKDEVVRAHVQLQLFKLYHNEEEIEKLNRELSQRNREID 250

  Fly   348 ACAEELKTHDEGTAALKQSRAEKETIIR------KEIEEYEA-LVKKREQIKKRLVTVESAYTEI 405
               ::.|..|.....||..:.|...::|      |||:|.:| |.:||.|..|
Zfish   251 ---KDRKKMDHVEEELKDKKKELGRMMRDQQNVEKEIKEKDAELNQKRPQYIK------------ 300

  Fly   406 QSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSKVTLNEELEKQQA 470
              ..|||..:.||    :|...|.|::..|:.:|.:.:||:.:::..::|:|:....|.:| ::|
Zfish   301 --AKENTAHKIKK----LEVARKSLQNAQKMYKKRKADIEELDREQGAVEMSRQEFEERME-EEA 358

  Fly   471 ELTKTTAPLTEKRLKLSDELVGLKEKVN----TAKGEVQVFESQLKILKQAETTESRKYETLKSS 531
            :.......|.|.::|   :...|||:.:    |...|::.|....|..:.....|.||....::.
Zfish   359 QSQGQDLTLEENQVK---QYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKIETEAK 420

  Fly   532 YEQSQKSLEEKVTRVDELKESIP----------RMKTEIASKSAEVDKMVKEERNLSMQCNKLRT 586
            .:|..:.:||...|:::|::.|.          ||:.|:   :.||:...:....::|:.|::..
Zfish   421 IKQKIREIEENQKRIEKLEDYIATSRQSLDEQRRMEEEL---TEEVELAKRRIDEINMELNQVME 482

  Fly   587 EINE-RSSVMQAQRSNNK--VLDFLMRMKMEGKIPG-ILGRLGDL-GGIDAKYDIAISTACGR-L 645
            ::.: |....:..|...|  :::.:.|:     .|| :.|||.|| .....||.||::...|: :
Zfish   483 QLGDARIDRQENSRQQRKAEIMESIKRL-----YPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNM 542

  Fly   646 DNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRV 710
            |.|:.|:.:|....|..:||......||:.||.:|  .:..:.::........:.|:::.|...:
Zfish   543 DAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLE--VKPTDEKLRELRGAKLVIDVIRYEPPHI 605

  Fly   711 RTAFYFALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRT 774
            :.|..:|..|.|||:::|...|||:|.. |::.|.|.|.:.:.:|.:|||.|     .:..:.|.
Zfish   606 KKALQYACGNALVCENVEDARRIAFGGPYRHKTVALDGTLFQKSGVISGGAS-----DLKAKARR 665

  Fly   775 KTAESADS-SQISQKALEDM--QIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLA 836
            ...::.|. .:..:|..|::  |::|:..:|.:...|.|...|:..::..::.|::.:..:..|.
Zfish   666 WDEKAVDKLKEKKEKLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLSLN 730

  Fly   837 VSITS-LEQQMA------SNLKQCEAQRQRMLKKTTDE------------------RAVKEREE- 875
            :...| ||.::|      :::|:....|:|.:.:..|.                  |.::|.||
Zfish   731 MQEKSKLESELANFGPRINDIKRIIQSRERDITQLRDRMNLVEDEVFFEFCKEIGVRNIREFEEE 795

  Fly   876 ----QIEAAKQELE-QAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVR 935
                |.|.||:.|| :.|....|:....|:.|.:.|   .|.|...|..:||..::||:|
Zfish   796 KVKRQNEIAKKRLEFETQKTRLAIQLDYEKNQLKED---QEKVMMWEQTVKKDENEIERL----- 852

  Fly   936 SLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEEL---EKEIEESEASI 997
                               ......::|..:|.:..|.:.:|:...||.|:   .:|:||....:
Zfish   853 -------------------KKEEHRHMKIIDETMAQLQDLKNQHLTKKGEVNDKNREMEEIRKKL 898

  Fly   998 EGAKSQSSDIKKEIDEI-TKEENKRNIERIEI-------DTKLQAAAGKMNKVKNDIPGWQAQLA 1054
            ..|..:.:.::||:..| ||.|.||: :|..:       |.||...:|.|:.:.....|.|.:.|
Zfish   899 GSANKELTQLQKEVTAIETKLEQKRS-DRHNLLQACKMQDIKLPLKSGTMDDISQGEGGSQVEDA 962

  Fly  1055 ---PLKLNEIPGE--------TEPQAPLKE-LNEEELEAE--TL-EALQYKQTMLEEDLKTKKPN 1104
               |...:.:..:        :.....||: |:|:|::.|  || :.|..:|::|:   :...||
Zfish   963 ISSPKASSSVHAKEALIEIDYSNLNEDLKDALSEDEIKGEMNTLQQRLNEQQSILQ---RISAPN 1024

  Fly  1105 LSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMIT 1169
            :..:::....|..:.:.....|....:..:.:..:|:::|.|:..|...|..:...:.|:|:.::
Zfish  1025 MKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALS 1089

  Fly  1170 LGGDAELEL--VDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYF 1232
            ....|:..|  .:..:|:.:|:|:....|.|.::.:.||||||||:::|||:||:|.|||:|.:.
Zfish  1090 RNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFV 1154

  Fly  1233 MDEIDAALDFKNVSIVGHYIKERT-KNAQFIIVSLRVNMFELANFLVGIY-KVSDCTDS----IT 1291
            :||||||||..|:..|.:|||::: :|.|.|::||:...:..|:.|:|:| :..||..|    ..
Zfish  1155 LDEIDAALDNTNIGKVANYIKDQSVQNFQAIVISLKEEFYTKADSLIGVYPEQGDCVISKVLTFD 1219

  Fly  1292 MLNYPPTLP 1300
            :..||...|
Zfish  1220 LSQYPDANP 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	58/150 (39%)
		Smc	89..1281	CDD:224117	330/1283 (26%)
		SMC_hinge	618..733	CDD:214944	33/117 (28%)
		ATP-synt_B	<825..904	CDD:304375	24/109 (22%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	45/99 (45%)
smc1a	NP_001155103.1	SMC_N	3..1208	CDD:280601	331/1287 (26%)
		ABC_SMC1_euk	4..>148	CDD:213242	58/149 (39%)
		SMC_hinge	513..628	CDD:214944	32/116 (28%)
		ABC_SMC1_euk	<1117..1220	CDD:213242	45/102 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820