DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and si:dkey-119f1.1

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001121806.1	Gene:	si:dkey-119f1.1 / 557127	ZFINID:	ZDB-GENE-070705-287	Length:	1090	Species:	Danio rerio

Alignment Length:	1355	Identity:	280/1355 - (20%)
Similarity:	515/1355 - (38%)	Gaps:	371/1355 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTRIGDIYIPPPVPPHCSMES 82
            |:|...|   ||..::.|..|.:.|||.      :.:.|...:|.::              |...
Zfish     4 RKSSNSR---LTPDKRSRLSQPETEEDG------EPIYFSAGDGLSQ--------------SQSV 45

  Fly    83 TGPRLIISKIVNRNFKSYAGEVELGP--FHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCK 145
            ||...||..|..|||..::   .|||  |..:...::|.||||||.|:.:::...|.:|  :...
Zfish    46 TGEVGIIESISLRNFMCHS---LLGPFAFGPNVNFVVGNNGSGKSAVLTALIVALGGKA--LTTN 105

  Fly   146 RVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDV-------------PD---SSIVIERTA 194
            |.|:|                   |..|.:|:.:. ||             |:   .|||::...
Zfish   106 RGSSL-------------------KGFVKEGESSA-DVSITLRNRGRDAYKPEKFGQSIVVDLRI 150

  Fly   195 MSDNSSYYQINDKRAQL-----KDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETG 254
            .|:....|::.....||     :::..:|...::.:: |...||..|: |...:..||:.:
Zfish   151 SSEGIRTYKLKSHTGQLVSAKKEELVSILDHFNIQVD-NPVSILTQEM-SKHFLHSKGEGD---- 209

  Fly   255 MLEYLEDIVGTQRYIRPLQQINQ------RVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDY 313
              :|...:..||     |.|:.:      :...||.:..|||....|      :|:|.|.:..:.
Zfish   210 --KYKFFMKATQ-----LDQMKEDYSYIMKTKTLTQNTVEKHRETLL------ELKQKFRDKEER 261

  Fly   314 LKKENELVRTKSFHIQKIISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIR--K 376
            .|....|...:    ||:..:|.........|.|   :|:|...|      |..||:.:.::  :
Zfish   262 YKSLASLDEMQ----QKLNELKNQMAWALVAEME---QEMKPMKE------QITAEERSTVKYDQ 313

  Fly   377 EIEEYEALVKKREQIKK-----------RLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKEL 430
            ::||::..|.:..:|.|           |:..::...:|::|.::..|::.|..:|.:.:....|
Zfish   314 KVEEWKGKVDEANKISKQLQDQLESVSERMQQLQPECSELKSRVQERNRELKTAEAALHRKRTNL 378

  Fly   431 EDLHKLPEKNQREIEDCNKKLESLEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKE 495
            .||.|  :|:|     .||:::.|:.|...:|          :..|....||...:..||..|..
Zfish   379 RDLEK--DKDQ-----LNKRIKELKHSISQMN----------SADTQARVEKMNHIQAELEELSF 426

  Fly   496 KVNTAKGEVQVFESQLKILKQAETTESRKYETLKSSYEQSQKSLEE-KVTRVDELK---ESIPRM 556
            :.:|...::..|:...:..|:.....||:.:.|:.:.:..|:.|.. :.:|.::|:   |.||.:
Zfish   427 RDSTLAQQIDQFKQACESAKERHARMSRERQDLQRAIDSKQRDLAAMESSRNNQLRRFGEHIPAL 491

  Fly   557 KTEIASKSAEVDKMVKEERNLSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGIL 621
            ...|                         .|.:.|..               .|||..|.: |..
Zfish   492 MEAI-------------------------DEAHHRGK---------------FRMKPVGPL-GFC 515

  Fly   622 GRLGDLGGIDAKYDIAISTAC---GRLDNIVTDNY---ETASAAIGALKEYNVGRATFITLDKIE 680
            .||.|       .|:|::..|   ..:.....||:   ......:|  :.|..||...|.:.:..
Zfish   516 IRLRD-------QDLALAVECCLKALMLAFCCDNHADERELERIMG--RFYQRGRRPQIIVSRFT 571

  Fly   681 HHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYFALRNTLV-CDDLEQGTRIAYGRERYRVVT 744
            :......:|..:..:.|.:...:.:|:.        .:.|.|: ...:|....|...|:..||:.
Zfish   572 NMLYNVGNRAVSHPDYPTVLQALDIENP--------VVANCLIDMRGIETILLIKDNRDARRVMQ 628

  Fly   745 LRGEMIEMTGTMSGGGSRPIR---GKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNY 806
            .:|          |...|..|   .:.|.||.|....|::                   |.|..|
Zfish   629 SKG----------GQAPRNCREAFTRDGDQVYTNRYYSSE-------------------QHRAQY 664

  Fly   807 CQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDER-AV 870
            ...   .:|.||:.|::.||...|:..|.        ||....:.:.|.|.|.:|::..|:| .|
Zfish   665 LSR---DVEEEIRHLQSALQTQRAQLDRF--------QQDMQQVGEEERQNQTLLRRAYDDRKKV 718

  Fly   871 KEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVR 935
            :||..:::|...||:           .:||.|       :|.:||:|.::::::.:|........
Zfish   719 QERSRKLQAELTELQ-----------NVEEPQ-------SEDLKPLEEELEELSGRISVCGEEFE 765

  Fly   936 SLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEELEKEIEESEASIEGA 1000
            :|.....|.              ::..:.||:..:...|..|...|:.|.:::.:..|:..:|.:
Zfish   766 ALRRQTQTC--------------KKEYEEAEKVFRQKKEAVNSIVEEVEPIKERLNNSDQEVERS 816

  Fly  1001 KSQSSDIKKEIDEITKEENKRNIERIE-IDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEI-PG 1063
            |..    :|..:    |:.|.:::.|| :.|.|       |:.:.::   ||.:|  |.:|| |.
Zfish   817 KHH----RKHYE----EKRKTHLQMIETLKTSL-------NQKEQEL---QAAIA--KASEICPE 861

  Fly  1064 ETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVY---------L 1119
            .::.:...|.|:.|      :..|:.| ...::|.:..:..:  ::|::|.|..:         |
Zfish   862 RSDVRRTAKSLDSE------INRLKSK-INTQQDQQGHRDTI--VREYHEAREKFGKISRQVKGL 917

  Fly  1120 DR-VRVLEDITSKRN----EMRDKYEEVR----------KRRYKEFMDGFSIITRKLKEMYQMIT 1169
            |. :..|..|.:.|:    ||| .|..||          :|.||    |..|...|.:.:...:.
Zfish   918 DAFIHQLSKIMTTRHNVYAEMR-MYLSVRCKYNFHSMLSQRGYK----GKMIFDHKNEILSISVQ 977

  Fly  1170 LGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMD 1234
            .|...:.:|.|                      :.:|||||::.|::..|.:|......|...:|
Zfish   978 PGEGGKADLSD----------------------MRSLSGGERSFSTVCFVLSLWEIAEVPFRALD 1020

  Fly  1235 EIDAALDFKNVSI---VGHYIKERTKNAQFIIVSLRVNMFEL-ANFLVGIYKVSD 1285
            |.|..:|..|..|   :...|....:..|||.::.: ||..| .|.|:.:.:::|
Zfish  1021 EFDVYMDMVNRRISMDMMLKIAASQRYRQFIFLTPQ-NMSSLPINSLIRVLRLND 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	42/181 (23%)
		Smc	89..1281	CDD:224117	263/1278 (21%)
		SMC_hinge	618..733	CDD:214944	20/121 (17%)
		ATP-synt_B	<825..904	CDD:304375	21/79 (27%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	25/94 (27%)
si:dkey-119f1.1	NP_001121806.1	Smc	52..1074	CDD:224117	263/1282 (21%)
		ABC_SMC6_euk	52..>208	CDD:213243	43/182 (24%)
		TBPIP	<241..319	CDD:284512	22/96 (23%)
		Laminin_II	319..>396	CDD:283628	17/83 (20%)
		ABC_SMC6_euk	<982..1077	CDD:213243	27/116 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900