DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and smc1al

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_997975.2	Gene:	smc1al / 403060	ZFINID:	ZDB-GENE-040426-57	Length:	1233	Species:	Danio rerio

Alignment Length:	1294	Identity:	337/1294 - (26%)
Similarity:	622/1294 - (48%)	Gaps:	190/1294 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHSSS-SYPN 159
            |||||.|...:||||: ||||||||||||||::|::.||...:.:.:|.|.:..|||.:. ..|.
Zfish    11 NFKSYKGRQIIGPFHK-FTAIIGPNGSGKSNLMDAISFVLAEKTSNLRVKTLKDLIHGAPVGKPA 74

  Fly   160 LRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKLLKKHHVD 224
            .....|.:.::|     ||. :::..|.|:|      .:||.|:||:|...|.|.::.|:|..:.
Zfish    75 ANRAFVTMVYQQ-----DGG-QELSFSRIII------GSSSEYRINNKVVGLSDYSEELEKLGIL 127

  Fly   225 LEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQLTDDRTEK 289
            ::...||:.||.||||||..||.:|       ...|:|..:....:...:..:.:.:..:|....
Zfish   128 IKARNFLVFQGAVESIAMKNPKERT-------ALFEEISRSGELAQEYDRCKKEMVKAEEDTQFN 185

  Fly   290 HNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQ-KIISI--KKSKLEQYTQE----HE 347
            ::|.|....|.|:.:|...||..|.:.::|:||.   |:| ::..:  .:|::|:..:|    ::
Zfish   186 YHRKKNIAAERKEAKQEKEEAERYQRLKDEVVRA---HVQLQLFKLYHNESEIEKLNRELAHRNK 247

  Fly   348 ACAEELKTHDEGTAALKQSRAE------KETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQ 406
            ...::.|..|.....||..:.|      .:.:|.|||:|.:|     |..:||.:.:::
Zfish   248 EIDKDRKRMDRVEEELKDKKKELGRMMRDQQMIEKEIKEKDA-----ELNQKRPLYIKA------ 301

  Fly   407 STMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSKVTLNEELEKQQAE 471
              .|||..:.||    :|...|.|::..|..:|.:.::::.:::..::|:::....|.:| ::|:
Zfish   302 --KENTAHKIKK----LEAARKSLQNAQKCYKKRKGDMDELDREQGAVEMARQEFEERME-EEAQ 359

  Fly   472 LTKTTAPLTEKRLKLSDELVGLKEKVN----TAKGEVQVFESQLKILKQAETTESRKYETLKSSY 532
            .......|.|.::|....   |||:.:    |...|::.|....|..:.....|.||....::..
Zfish   360 SQGQDLQLEENQVKAYHR---LKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKIETEAKI 421

  Fly   533 EQSQKSLEEKVTRVDELKESI----------PRMKTEIASKSAEVDKMVKEERNLSMQCNKLRTE 587
            :|..:.:||...|:::|::.|          .||:.|:..:..:..:.:.|   ::|:.|::..:
Zfish   422 KQKIREIEENQKRIEKLEDYITTSRQSLDEQKRMEEELTEEVEQAKRRIDE---INMELNQVMEQ 483

  Fly   588 INE-RSSVMQAQRSNNK--VLDFLMRMKMEGKIPG-ILGRLGDL-GGIDAKYDIAISTACGR-LD 646
            :.: |....:..|...|  :|:.:.|:     .|| :.|||.|| .....||.||::...|: :|
Zfish   484 LGDARIDRQENSRQQRKAEILESIKRL-----YPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD 543

  Fly   647 NIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVR 711
            .|:.|:.:|....|..:||......||:.||.:|  .:..:.::........:.|:::.|..:::
Zfish   544 AIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLE--VKPTDEKLRELRGAKLVIDVIRYEPPQIK 606

  Fly   712 TAFYFALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTK 775
            .|..:|..|.||||::|...|||:|.. |::.|.|.|.:.:.:|.:|||.|     .:..:.|..
Zfish   607 KALQYACGNALVCDNVEDARRIAFGGPYRHKTVALDGTLFQKSGVISGGAS-----DLKAKARRW 666

  Fly   776 TAESADSSQISQKALED---MQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAV 837
            ..::.|..:..::.|.|   .|::|:..:|.:...|.|...|:..::..::.|::.:..:..|.:
Zfish   667 DEKAVDKLKDRKEKLTDELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLSLNM 731

  Fly   838 SITS-LEQQMA------SNLKQCEAQRQRMLKKTTDE------------------RAVKEREE-- 875
            ...| ||.::|      :::|:....|:|.:|...|.                  |.::|.||
Zfish   732 QEKSKLESELANFGPRINDIKRIIQSRERDMKDLKDRMNVVEDEVFVEFCKEIGVRNIREFEEEK 796

  Fly   876 ---QIEAAKQELE-QAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRS 936
               |.|.||:.|| :.|....|:....|:.|.:.|   .|.|...|..:||..::||||
Zfish   797 VKRQNEIAKKRLEFETQKTRLAIQLDYEKNQLKED---QEKVVMWEQTVKKDENEIEKL------ 852

  Fly   937 LNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEEL---EKEIEESEASIE 998
                              ....:.|:|..:|.:..|.:.:|:...||.|:   ..|:||....:.
Zfish   853 ------------------KKEEQRNMKIIDETMAQLQDLKNQHLTKKSEVNDKNHEMEEIRKKLG 899

  Fly   999 GAKSQSSDIKKEIDEI-TKEENKRNIERIEI-------DTKLQAAAGKMNKVKNDIPGWQAQ--- 1052
            ||..:.:.::||:..| ||.|.||: :|..:       |.||...:|.|:.:..:....||:
Zfish   900 GANKELTQLQKEVTAIETKLEQKRS-DRHNLLQACKMQDIKLPLRSGTMDDISQEEGNSQAEESL 963

  Fly  1053 ----------LAPLKLNEIPGETEPQAPLKELNEEELEAE--TL-EALQYKQTMLEEDLKTKKPN 1104
                      ||...|.||...:..:.....|::||::||  || :.|..:|::|:   :...||
Zfish   964 SSSQKTSSTVLAKEALIEIDYNSLSEDLKDSLSDEEIKAEMNTLQQRLNEQQSILQ---RISAPN 1025

  Fly  1105 LSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMIT 1169
            :..:::....|..:.:.....|....:..:.:..:|:::|.|:..|...|..:...:.|:|:.::
Zfish  1026 MKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFHACFESVATNIDEIYKALS 1090

  Fly  1170 LGGDAELEL--VDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYF 1232
            ....|:..|  .:..:|:.:|:|:....|.|.::.:.||||||||:::|||:||:|.|||:|.:.
Zfish  1091 RNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFV 1155

  Fly  1233 MDEIDAALDFKNVSIVGHYIKERT-KNAQFIIVSLRVNMFELANFLVGIY-KVSDCTDS 1289
            :||||||||..|:..|.:|||::: :|.|.|::||:...:..|:.|:|:| :..||..|
Zfish  1156 LDEIDAALDNTNIGKVANYIKDQSVQNFQAIVISLKEEFYTKADSLIGVYPEQGDCVIS 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	60/150 (40%)
		Smc	89..1281	CDD:224117	333/1283 (26%)
		SMC_hinge	618..733	CDD:214944	34/117 (29%)
		ATP-synt_B	<825..904	CDD:304375	25/109 (23%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	45/96 (47%)
smc1al	NP_997975.2	SMC_N	3..1209	CDD:280601	334/1287 (26%)
		ABC_SMC1_euk	4..>148	CDD:213242	60/149 (40%)
		SMC_hinge	513..628	CDD:214944	33/116 (28%)
		ABC_SMC1_euk	<1118..1221	CDD:213242	45/97 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820