DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and Smc2

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001102136.2	Gene:	Smc2 / 362519	RGDID:	1305227	Length:	1191	Species:	Rattus norvegicus

Alignment Length:	1328	Identity:	309/1328 - (23%)
Similarity:	557/1328 - (41%)	Gaps:	279/1328 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFG-CRANRIRCKRVSTL 150
            :.:..|:...|||||...|:..|...|.||.|.|||||||::||:.|:.| ...:::|...:..|
  Rat     1 MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly   151 IHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVA 215
            ::.:.. ..:...||::.|.. .||............|.:.|..:....:.|.||...|....|.
  Rat    66 VYKNGQ-AGITKASVSITFDN-SDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQ 128

  Fly   216 KLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVD 280
            .|.....:::.:..|||:||.:..:..|||       ..:|..:|:..||:.|         ...
  Rat   129 DLFCSVGLNVNNPHFLIMQGRITKVLNMKP-------PEILSMIEEAAGTRMY---------EYK 177

  Fly   281 QLTDDRTEKHNRCKLAEREMKD-LEQPFNEAVDYLKKEN------ELVRTKSFHIQKIISIKKSK 338
            ::...:|.:....||  :|:|. ||:.....:..||:|.      :.|..:..|:.::....:..
  Rat   178 KIAAQKTIEKKEAKL--KEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240

  Fly   339 LEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRK---EIEEYEALVKKREQIKKRLVTVES 400
            |.:.|:|..  |.|||...:....|::..:|.|..|:.   ||||.|.  :|.::....|.::|.
  Rat   241 LAEDTKERS--AGELKEMQDKILKLQEVLSENEKKIKALNCEIEELEK--RKDKETGGILRSLED 301

  Fly   401 AYTEIQSTMENTNKQ-----RKKDKAQIEKNEKEL-----EDLHKLPEKNQREIEDCNKKLESLE 455
            |:.|.|..  ||..|     :||:.|..|...|||     ||...|..| ::|::.....|..|:
  Rat   302 AFAEAQRV--NTKSQSAFDLKKKNLASEETKRKELEKNMAEDSKALAAK-EKEVKKLTDGLHGLQ 363

  Fly   456 VSKVTLNEELEKQQAELTKTTAPLTEK----RLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQ 516
            .:.....|.|...|......:|.|:..    ...|:.:::..|..::.|:...:..:.:||..:|
  Rat   364 EASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTGAKQAQMKLKHAQQ 428

  Fly   517 AETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDK---MVKEERNLS 578
            ....:..:...:.|.|::.|::.|    .|.::||   :::||:...:.|.:|   ::::.|.:|
  Rat   429 ELKNKQAEVRKMDSGYKKDQEAFE----AVKKVKE---KLETEMKKLNYEDNKEERLLEKHRQVS 486

  Fly   579 MQCNKLRTEI--------NERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYD 635
            ...:.|:...        |.|.:....:::.|:           ..:.|::..|     |:.| |
  Rat   487 RDISNLKGTYEALLAKFPNLRFAYKDPEKNWNR-----------NCVKGLVASL-----INVK-D 534

  Fly   636 IAISTAC-----GRLDNIVTDNYETASAAI--GALKEYNVGRATFITLDKIE------HHRREAN 687
            .:.:||.     .||.|:|.|...|....:  |.||.    |.|.|.|:||.      ...|.|.
  Rat   535 NSTATALELVAGERLYNVVVDTEVTGKKLLEKGELKR----RYTIIPLNKISARCIAPETLRVAQ 595

  Fly   688 SRINTPENVPRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYG-RERYRVVTLRGEMIE 751
            :.:. |.||.....||..:.: ::.|..|....|.||::::...::|:. |...|.|||.|::.:
  Rat   596 NLVG-PNNVHVALSLVDYKPE-LQKAMEFVFGTTFVCNNMDNAKKVAFDKRIMTRTVTLGGDVFD 658

  Fly   752 MTGTMSGGGSRPIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQE------- 809
            ..||:|||..     .....:.||..|..|.....:...:::|...|||....|..::
  Rat   659 PHGTLSGGAR-----SQAASILTKFQELKDVQAELRTKEKELQALEEELAGLKNVAEKYRQLKQQ 718

  Fly   810 -----QQGSL-------------EREIQTLKNGLQRDEAEYKRLAVSITSLEQQ---MASNLKQC 853
                 ::|.|             :.|:..||..::..|...|.........|::   :.:.:|..
  Rat   719 WEMKTEEGDLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQKKAEEKYEALENKMKNA 783

  Fly   854 EAQRQRMLK---------KT---TDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYD 906
            ||:|::.||         ||   ...:.:||:::::||...|||:.: .|.|.:.|      |.|
  Rat   784 EAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK-REHASNEQ------QLD 841

  Fly   907 TLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEEKLKS 971
            .: ||::|..|       .|||.:||.|                              |:.| :|
  Rat   842 AV-NEAIKAYE-------GQIEIMAAEV------------------------------AKNK-ES 867

  Fly   972 LNEDRNKAKEKKEELEKE---IEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQ 1033
            :|:.:|:..::||.:..:   |::..|.:.....|::|.:.:|.|:....:|...|..:
  Rat   868 VNKAQNELMKQKEIISAQDNIIKDKCAEVAKHNLQNNDSQLKIKELDHSISKHKREADD------ 926

  Fly  1034 AAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDL 1098
             ||.|::|:.||.....|:      ..:.|:.......|..|.:| ..:.|:.||..:..|..::
  Rat   927 -AAAKVSKMLNDYDWINAE------KHLFGQPNSAYDFKTNNPKE-AGQRLQKLQEVKEKLGRNV 983

  Fly  1099 KTKKPNL--SCIKEFNE----KRLVYLDRVRVL---EDITSKRNE-MRDKYEEVRKRRYKEFMDG 1153
            ..:..|:  ...:.:|:    ||:|..|:.::|   ||:..|:|: :...:::|.    |:|...
  Rat   984 NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQALNIAWQKVN----KDFGSI 1044

  Fly  1154 FSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPK---------------KSWK-Y 1202
            ||.:                            ..|.|..:.||:               .:|| .
  Rat  1045 FSTL----------------------------LPGANAMLAPPEGQTVLDGLEFKVALGNTWKEN 1081

  Fly  1203 ISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLR 1267
            ::.||||:::|.:|:|:.::..:||:|:|.:||:|||||..:...:|..::....::|||:|||:
  Rat  1082 LTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLK 1146

  Fly  1268 VNMFELAN------FLVGIYKVSDCTDS 1289
            ..||..||      |:.|:..|:..|.|
  Rat  1147 EGMFNNANVLFKTKFVDGVSTVARFTQS 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	45/159 (28%)
		Smc	89..1281	CDD:224117	306/1316 (23%)
		SMC_hinge	618..733	CDD:214944	34/127 (27%)
		ATP-synt_B	<825..904	CDD:304375	21/93 (23%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	37/116 (32%)
Smc2	NP_001102136.2	Smc	1..1168	CDD:224117	306/1320 (23%)
		ABC_SMC2_euk	1..>172	CDD:213240	49/179 (27%)
		L_lactis_ph-MCP	252..>465	CDD:115336	54/224 (24%)
		SMC_hinge	522..639	CDD:214944	34/128 (27%)
		PCRF	693..>761	CDD:305100	11/67 (16%)
		DUF4200	740..841	CDD:290574	25/107 (23%)
		P-loop_NTPase	<1074..1168	CDD:304359	33/93 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810