Protein Alignment glu and SMC5

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 1268
• Identity: 269/1268 - (21%)
• Similarity: 484/1268 - (38%)
• Gaps: 355/1268 - (27%)

  Fly    84 GPRLIISK--------IVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRAN 140
            |.|.:.||        :..::|.||: |:...|.|. ...:.||||||||.:
  Fly     3 GDRALSSKQLAGRIHSVYCKDFVSYS-EITFHPKHY-LNVLTGPNGSGKSTI------------- 52

  Fly   141 RIRCKRVSTLIHSSSSYPNL--RSCSVAVHFKQIVDKGDGTC-----EDVPDSSIVIERTAMSDN 198
                  ||.:|......|.|  ||.|||.:.:.  :|...|.     ...|:::....|...|:.
  Fly    53 ------VSAIILGLGGEPILLDRSASVADYIQS--NKTSATIIVRVYGRTPNTTETFRRIINSNG 109

  Fly   199 SSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIV 263
            .|.:.:|||....|:....:...::.:.:....:.|..|:..:.|.|:             |.::
  Fly   110 LSTFSVNDKDTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQ-------------ELLL 161

  Fly   264 GTQRYIRPLQQINQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLK------KENELVR 322
            .|...:.....||. .:.|...|||:.|.....|:|..||.:. .:.:::|:      ||.|.|:
  Fly   162 NTMSSVCDEDLINS-FNSLKQMRTEQANVHANREKEKSDLVKK-QKRLEHLQMTVSQYKEREEVK 224

  Fly   323 TKSFHIQKIISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKK 387
            .|    .::.|.||..:|  ||..||.|.|:||.      :|.::.:.:    |...:::.|::.
  Fly   225 QK----LQVYSAKKLWVE--TQAGEAKAAEMKTQ------VKNAKTQSD----KLKNQHDKLLQS 273

  Fly   388 REQIKKRLVTVESAYTEIQSTMENTNKQR-----KKD--KAQIEKNEKELEDLHKLPEKNQREIE 445
            :|||:|...::..|..|....:||...::     |.|  |..|.:.:.|||...|   |::|...
  Fly   274 QEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIK---KSRRTAT 335

  Fly   446 DCNKKLESLEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQ 510
            :|:           .||:.:|.:..||    ..|.:.|..:..||...||....|:|
  Fly   336 ECD-----------NLNQLVENKIYEL----ETLNKSRPLIVSELERAKESCAAARG-------- 377

  Fly   511 LKILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEER 575
             |.::|               |.: ::.||:|:.  ||:   ||    ||.:...:::::    |
  Fly   378 -KAMEQ---------------YSR-RRQLEQKLN--DEM---IP----EITAYKLKIERL----R 412

  Fly   576 NLSMQCNKLRTEINERSSVMQAQRSNNKV-LDFLMRMKMEGKI----PGILGRLGDLGGIDAKYD 635
            |:.||      :|:|    ::|:..|..| :::|.:.|...|:    |.|| .|......|||:
  Fly   413 NVKMQ------KIDE----IRAKNPNLVVAMNWLAQNKQRYKLNVYDPMIL-ELTVQNHEDAKF- 465

  Fly   636 IAISTACGRLDNIVT--DNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVP- 697
                     |:|:|.  |.:..|....|.:.            |.|.....:....:|.....|
  Fly   466 ---------LENVVAQRDLFAFACEDKGDMS------------DLINELCVKQKLGVNVIYCAPS 509

  Fly   698 -RLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQG-------TRIAYGRERYRVVTLRGEMIEMTG 754
             ||....|...|.:|:   |..|:.||  ||..|       ...:|......:.|      |..|
  Fly   510 DRLVYSPKTPIDDLRS---FGFRSYLV--DLVTGPIPLINKLCASYSIHNIPIGT------EAVG 563

  Fly   755 TMSGGGSRPIRGKMG-------TQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQG 812
            ..:....:.||...|       |..|.::......|.|..|. :.:.:.:::|...:..|.|
  Fly   564 NYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKN-QLITVDSQQLALVMKQCSE--- 624

  Fly   813 SLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQI 877
             ..:|..::||.:.:.:.|::||        |.:|                         ::||.
  Fly   625 -AVKESDSIKNAITQTDNEFERL--------QAVA-------------------------KDEQE 655

  Fly   878 EAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRN-ESVKPVEAK--------IKKVNSQIEKLAAN 933
            :..|.:.:.|.|  .::.::||.:|.:.:.||| :|:..:|..        :||:.....:|.:.
  Fly   656 KRRKLDQKIAHF--NSLKTEIETLQKKLEALRNSDSLDCLETNFCNSLHKDLKKIFDADAELCSC 718

  Fly   934 VRSLNVGLATADRNITKIT---GNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEELEKEIEESEA 995
            :::::..:...:...||::   ..:....|.:|.:||:.|:...|..:..:..|....::.:.::
  Fly   719 LKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKS 783

  Fly   996 SIEG------AKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLA 1054
            :|:|      ..|.....|||.         |.:|.|::.           :::..|..:||:|
  Fly   784 AIQGLCHGEIPTSSKFPFKKEF---------RELENIDLP-----------ELREAIHDFQARL- 827

  Fly  1055 PLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYL 1119
                          ..:|.:|.|.:  .:.:.||.:...|||.::
  Fly   828 --------------ECMKSVNSEAI--SSYQGLQNEVKQLEEGIQ-------------------- 856

  Fly  1120 DRVRVLEDITSKRNEMRDKYE-------EVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELE 1177
            :.|...:.|.|..:.:.||:|       |....::.|||:....:              |:..|.
  Fly   857 ESVNQAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYV--------------GEVVLS 907

  Fly  1178 LVDSMDPFTEGVNFTVR-------PPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDE 1235
            ..|..|..:.|:...|:       .|..  |:|.  ||||:.:|......:|.:....|...:||
  Fly   908 KTDKYDFDSYGIQIMVQFRRGLQLQPLD--KFIQ--SGGERAVSIAIYSLSLQHVTHVPFRCVDE 968

  Fly  1236 IDAALDFKNV-SIVGHYIKERTK--NAQFIIVS 1265
            |:..:|..|. .|....:||.||  :||::.|:
  Fly   969 INQGMDATNERHIFDLLLKEATKHGSAQYLFVT 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	267/1263 (21%)
SMC5	NP_996141.2	P-loop containing Nucleoside Triphosphate Hydrolases	14..>160	CDD:476819	39/181 (22%)
		SMC_N	22..>425	CDD:481474	122/522 (23%)
		SMC_prok_B	<193..1001	CDD:274008	217/1039 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<919..1025	CDD:476819	24/87 (28%)