Protein Alignment glu and Smc4

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001032262.2
• Gene: Smc4 / 295107
• RGDID: 1306680
• Length: 1286
• Species: Rattus norvegicus
• Alignment Length: 1301
• Identity: 516/1301 - (39%)
• Similarity: 792/1301 - (60%)
• Gaps: 45/1301 - (3%)

  Fly     5 RPS------KGTPKAAGGARQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGT 63
            :||      :|.|.:..||...|:...|.........|:...||.|:.  :|::.|
  Rat     7 KPSTACHQEEGPPPSEDGALSEGEKEQPDCEVDSAAAAETPGEELDSR--SLEEIL--------- 60

  Fly    64 RIGDIYIPPPVPPHCSMESTGPRLIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVI 128
                ..||||.||..:.|:..|||:|:.|||:||||||||..|||||:.|:.|||||||||||||
  Rat    61 ----NSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVI 121

  Fly   129 DSMMFVFGCRANRIRCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERT 193
            |||:||||.||.:||.|::|.|||:|..:.:::||:|.|||::|:||.....:.:|:|:..:.||
  Rat   122 DSMLFVFGYRAQKIRSKKLSVLIHNSDEHTDIQSCTVEVHFQKIIDKEGDDYDVLPNSNFYVSRT 186

  Fly   194 AMSDNSSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEY 258
            |..||:|.|.|:.|:...|||..||:.|.:||:||||||||||||.|||||||||||::.|||||
  Rat   187 AYRDNTSVYHISGKKRTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEY 251

  Fly   259 LEDIVGTQRYIRPLQQINQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRT 323
            ||||:|..|...|::.:.:||:.|.:.|.||.||.|:.|:|...||...|.|:::|..|||:.:.
  Rat   252 LEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFKK 316

  Fly   324 KSFHIQKIISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKR 388
            |:...|..|...::::.:...:.|...|:.|...|.:..|......|.:.::...::...:.|..
  Rat   317 KNHICQYYIYDLQNRIAEMKTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDIEKKLNKVTKFI 381

  Fly   389 EQIKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLES 453
            ||.|::...::....:::..:::...:.||.:.|::|:::::|:|..:|.|::..|.:...:..|
  Rat   382 EQNKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSIPAKSKNVINETTTRNNS 446

  Fly   454 LEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAE 518
            ||..:....::|::....|.:.|..|.:::.....||:|..:.||.|:.:::|.:|:|.|.....
  Rat   447 LEKEREKEEKKLKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRH 511

  Fly   519 TTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNK 583
            .|...:....|.:...:.::|:|:...:.::...:|:.:.|:..|..|:.|:.:||.||....:.
  Rat   512 NTAVSQLSKAKDALITASETLKERKAAIKDINTKLPQAQQELKEKEKELQKLTQEEINLKSLVHD 576

  Fly   584 LRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNI 648
            |..::.|..|.:...||..||||.:::.|..|:||||.|||||||.||.|||||||:.|..||.|
  Rat   577 LFQKVEEAKSSLATNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYI 641

  Fly   649 VTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTA 713
            |.|:.:||...:..||::|:|.||||.|||:....::.| :|.||||.|||:|||||:::.:|.|
  Rat   642 VVDSIDTAQECVNFLKKHNIGVATFIGLDKMAVWAQKMN-KIQTPENTPRLFDLVKVKNEEIRQA 705

  Fly   714 FYFALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTA 777
            ||||||:|||.::|:|.||:||.|: |:|||||:|::||.:|||:||||:.:||:||:.|
  Rat   706 FYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMTGGGSKVMRGRMGSSV----- 765

  Fly   778 ESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSL 842
                ..:||.:.:..|:.|.|....:....|||:...|..|..||...:......::...||..|
  Rat   766 ----VDEISVEEVNKMECQLERHSKQAAQVQEQKVQHEEAIVKLKQSEREMRNTLEKFTASIQGL 826

  Fly   843 EQQ---MASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQA--VSSQIEEIQ 902
            .:|   :...:|:.||   .:|....|::..|..||.:...|:|.:..  ||:|  |.::|:.:.
  Rat   827 SEQEEYLCVQIKELEA---NVLTTAPDKKQQKLLEENVNVFKKEYDAV--AEKAGKVEAEIKRLH 886

  Fly   903 NQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEE 967
            :....:.|..:|..:.|:..:|.|:::.|:.:....|.:.|||||:.|...:.....:.||..|:
  Rat   887 DTIIDINNRKLKAQQNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEKEIKDTEK 951

  Fly   968 KLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKL 1032
            ::..|..:....::..||:.|..:::|.|:...:.:...:.:|:..|...|:....:.:.|..||
  Rat   952 EINDLKTELKNIEDNAEEVIKNTKDAEKSLPEIQKEHRALLQELKVIQDNEHALQKDALSIKLKL 1016

  Fly  1033 QAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEA-ETLEALQYKQTMLEE 1096
            :...|.:::..:.|..||.:::.:||:  |.|..|...:..|::|:||| ::.:::..:..:||.
  Rat  1017 EQIDGHISEHNSKIKYWQKEISKIKLH--PVEDNPVETVSVLSQEDLEAIKSPDSITNQIALLEA 1079

  Fly  1097 DLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKL 1161
            ..:..||||..|.|:.:|..:||.||..|:.|||:|:..|..||::||:|..|||.||.:||.||
  Rat  1080 QCREMKPNLGAIAEYKKKEELYLQRVGELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKL 1144

  Fly  1162 KEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYK 1226
            ||.|||:|||||||||||||:|||:||:.|:|||||||||.|.|||||||||||||||||||:||
  Rat  1145 KENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYK 1209

  Fly  1227 PSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDSIT 1291
            |:||||||||||||||||||||..||.|:||||||||:|||.||||:::.|:||||..:.|.|:.
  Rat  1210 PTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVA 1274

  Fly  1292 M 1292
            :
  Rat  1275 V 1275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	490/1204 (41%)
Smc4	NP_001032262.2	SMC_N	81..1272	CDD:426784	491/1207 (41%)