DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and SMC5

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_055925.2	Gene:	SMC5 / 23137	HGNCID:	20465	Length:	1101	Species:	Homo sapiens

Alignment Length:	1268	Identity:	259/1268 - (20%)
Similarity:	485/1268 - (38%)	Gaps:	313/1268 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PPVPPHCSMESTGPRL--IISKIVNRNFKSY-AGEVELGPFHQSFTAIIGPNGSGKSNVIDSM-M 132
            |.:|   .::|:||.:  .|.:|...||.:| ..||..||   ....|:|.||:|||:::.:: :
Human    37 PQLP---LLQSSGPFVEGSIVRISMENFLTYDICEVSPGP---HLNMIVGANGTGKSSIVCAICL 95

  Fly   133 FVFGCRANRIRCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVD----KGDGTCEDVPDSSIVIERT 193
            .:.|..|...|..:|...:.        |.||     :.:|:    :..|        ::||.|.
Human    96 GLAGKPAFMGRADKVGFFVK--------RGCS-----RGMVEIELFRASG--------NLVITRE 139

  Fly   194 A-MSDNSSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLE 257
            . ::.|.|::.||.|....|.|            ..:...|..:|.::....|:.:. .|...|.
Human   140 IDVAKNQSFWFINKKSTTQKIV------------EEKVAALNIQVGNLCQFLPQDKV-GEFAKLS 191

  Fly   258 YLEDIVGTQRYIRPLQQINQRVDQLTDDRTEKHN-RCK---LAEREMKDLEQPFNEAVDYLKKEN 318
            .:|.:..|::.|.|               .|.|. .|:   |.|:| |.||....|..:||
Human   192 KIELLEATEKSIGP---------------PEMHKYHCELKNLREKE-KQLETSCKEKTEYL---- 236

  Fly   319 ELVRTKSFHIQKIISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSR--AEKETIIRKEIEEY 381
                      ||::    .:.|:|.|:.|...|. |.|.:....|:..|  .|.|. :|:|.||.
Human   237 ----------QKMV----QRNERYKQDVERFYER-KRHLDLIEMLEAKRPWVEYEN-VRQEYEEV 285

  Fly   382 EALVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIED 446
            :.:   |:::|:.:..::.....:...:|....:|...:|:|::...::::..:..::.|..||.
Human   286 KLV---RDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIER 347

  Fly   447 CNKKLESLEVSK-VTLNEELEKQQ--AELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFE 508
            .:|.:|.|:.:. |..||||::|:  ....|....| :..||.::....|:.:::....:::..:
Human   348 KDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDL-QNELKTTENCENLQPQIDAITNDLRRIQ 411

  Fly   509 SQLKILKQAETTESRK-YETLKSSYEQSQKSLEEKVTRVDEL---KESIPRMKTEIASKSAEVDK 569
            .: |.|.:.|..:.|: .|||    |:.:||:::.:.|.|.|   ||...|.:..   .:.:...
Human   412 DE-KALCEGEIIDKRRERETL----EKEKKSVDDHIVRFDNLMNQKEDKLRQRFR---DTYDAVL 468

  Fly   570 MVKEERNLSMQ--CNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGG--I 630
            .::..|:...|  |..:...||.:         :||...::     |..||.     .||..  .
Human   469 WLRNNRDKFKQRVCEPIMLTINMK---------DNKNAKYI-----ENHIPS-----NDLRAFVF 514

  Fly   631 DAKYDIAISTACGRLDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEH-----HRREANSRI 690
            :::.|:.:..      ..|.||.:....|:.|.|.....:|...:|::::.     :.||.   .
Human   515 ESQEDMEVFL------KEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLREL---F 570

  Fly   691 NTPENVPRL----YDL--VKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEM 749
            :.|:.|...    |.:  |.|..::.|......::.|.:       .:|....|:|.|.|
Human   571 DAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRL-------KQIYTAEEKYVVKT----- 623

  Fly   750 IEMTGTMSGGGSRPIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSL 814
                                    :..:....||..|.|..:.:.:..:..|.|  :.:||...:
Human   624 ------------------------SFYSNKVISSNTSLKVAQFLTVTVDLEQRR--HLEEQLKEI 662

  Fly   815 EREIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEA 879
            .|::|.:.:||         :|:..||...:...|       ..|..||...||..|:|:
Human   663 HRKLQAVDSGL---------IALRETSKHLEHKDN-------ELRQKKKELLERKTKKRQ----- 706

  Fly   880 AKQELEQAQFAEQAVSSQIEEIQ-NQYDTLR-NESVKPVEAKIKKVNSQIEKLAANVRSL----- 937
                      .||.:||::..:: .:.||.. .|..:....|||::|.|..||...:.:|
Human   707 ----------LEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICT 761

  Fly   938 NVGLATAD---RNITKITGNNNNLRENIKAAEEKLK-------SLNEDRNKAKEKKEELEKEIEE 992
            ::.:...|   :|.|.|: ..|.|..:..||..:|:       .|:|:|.:..:|.:||.|.
Human   762 SLHIQKVDLILQNTTVIS-EKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKR--- 822

  Fly   993 SEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLK 1057
                           .:::..:..|:......:.::.|               ||.......|:.
Human   823 ---------------ARQVCNLGAEQTLPQEYQTQVPT---------------IPNGHNSSLPMV 857

  Fly  1058 LNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRV 1122
            ..::|...:....|  |.||...|.....|                |.:.::|:.::.    :.:
Human   858 FQDLPNTLDEIDAL--LTEERSRASCFTGL----------------NPTIVQEYTKRE----EEI 900

  Fly  1123 RVL-EDITSKRNEMRDKYEE----VRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSM 1182
            ..| |::..|:.|: |:|.|    |::|......:....|..|....:..:...|:.:|...:..
Human   901 EQLTEELKGKKVEL-DQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEE 964

  Fly  1183 DPFTEGVNFTVRPPKKSWKYISNL-----SGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDF 1242
            |....|:.  :|...:|...:..|     ||||:::|::..:.||......|...:|||:..:|.
Human   965 DYDKYGIR--IRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDP 1027

  Fly  1243 KN-----VSIVGHYIKERTKNAQFIIVSLRVNM 1270
            .|     ..:|....||.|....||...|..|:
Human  1028 INERRVFEMVVNTACKENTSQYFFITPKLLQNL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	37/167 (22%)
		Smc	89..1281	CDD:224117	254/1249 (20%)
		SMC_hinge	618..733	CDD:214944	21/127 (17%)
		ATP-synt_B	<825..904	CDD:304375	16/79 (20%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	23/85 (27%)
SMC5	NP_055925.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		2/8 (25%)
		ABC_SMC5_euk	51..>196	CDD:213244	41/181 (23%)
		Smc	53..1055	CDD:224117	252/1242 (20%)
		Flexible hinge	446..646		44/266 (17%)
		ABC_SMC5_euk	<975..1077	CDD:213244	23/86 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900