DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and Smc5

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_006527043.1	Gene:	Smc5 / 226026	MGIID:	2385088	Length:	1102	Species:	Mus musculus

Alignment Length:	1245	Identity:	246/1245 - (19%)
Similarity:	461/1245 - (37%)	Gaps:	299/1245 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ISKIVNRNFKSY-AGEVELGPFHQSFTAIIGPNGSGKSNVIDSM-MFVFGCRANRIRCKRVSTLI 151
            |.:|...||.:| ..||..||   ....|||.||:|||:::.:: :.:.|..|...|..:|...:
Mouse    53 IVRIAMENFLTYDICEVSPGP---HLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFV 114

  Fly   152 HSSSSYPNLRSCSVAVHFKQIVD----KGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLK 212
            .        |.||     |.:|:    :..|       :.|:.....:..|.|::.||.|....|
Mouse   115 K--------RGCS-----KGLVEIELFRTSG-------NLIITREIDVIKNQSFWFINKKPVTQK 159

  Fly   213 DVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQ 277
            .|            ..:...|..:|.::....|:.:. .|...|..:|.:..|::.:.|
Mouse   160 IV------------EEQVAALNIQVGNLCQFLPQDKV-GEFAKLSKIELLEATEKSVGP------ 205

  Fly   278 RVDQLTDDRTEKHN-RCKL---AEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSK 338
                     .|.|. .|:|   .|:| |.||....|..:||:|   :|:               :
Mouse   206 ---------PEMHRYHCELKNFREKE-KQLETSCKEKTEYLEK---MVQ---------------R 242

  Fly   339 LEQYTQEHEACAEELKTHDEGTAALKQSR--AEKETIIRKEIEEYEALVKKREQIKKRLVTVESA 401
            .|:|.|:.|...|. |.|.:....|:..|  .|.|.:    .:|||.:...|:::|:.:..::..
Mouse   243 NERYKQDVERFYER-KRHLDLIEMLEAKRPWVEYENV----RQEYEGVKLIRDRVKEEVRKLKEG 302

  Fly   402 YTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVS-KVTLNEEL 465
            ...:...:|..::||...:.:|::...::::..:..::.|..||..:::::.|:.: .|..||||
Mouse   303 QIPMTRRIEEIDRQRHTLEVRIKEKSTDIKEASQKCKQRQDLIERKDRQIKELQQALTVKQNEEL 367

  Fly   466 EKQQAELTKTTAPL--TEKRLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAETTESRKYETL 528
            ::|: .::.|...:  .:..||.::....|:.:::|...:::..:.: |.|.:.|..:.::.
Mouse   368 DRQK-RISNTRKMIEDLQSELKTAENCENLQPQIDTVTNDLRRVQEE-KALCEGEIIDKQRE--- 427

  Fly   529 KSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLRTEINERSS 593
            |...|:.::|:.:.:||.|.|...                   ||:        |||....:...
Mouse   428 KEMLEKQRRSVSDHITRFDNLMNQ-------------------KED--------KLRQRYRDTYD 465

  Fly   594 VMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVTDNYETASA 658
            .:...|:|..      |.|.....| |:..:......:||| :....:...|...|.::.|....
Mouse   466 AVLWLRNNRD------RFKQRVCEP-IMLTINMKDNKNAKY-VENHISSNDLRAFVFESQEDMEI 522

  Fly   659 AIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYFALRNTLV 723
            .:..:::....|...:...||.:..:..:..:|                |..:..|:..||....
Mouse   523 FLREVRDNKKLRVNAVIAPKISYADKAPSRSLN----------------DLKQYGFFSYLRELFD 571

  Fly   724 CDDLEQG--------TRIAYGRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRT------ 774
            ..|....        ..:..|.||.|      |.||          |.|:.....|:.|
Mouse   572 APDPVMSYLCCQYHIHEVPVGTERTR------ERIE----------RVIQETRLKQIYTAEEKYV 620

  Fly   775 -KTAESAD---SSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRL 835
             ||:..::   ||..|.|..:.:.:..:..|.|  :.:||...:.|:::.:.:||         .
Mouse   621 LKTSVYSNKVISSNTSLKVAQFLTVTVDLEQRR--HLEEQLKEMNRQLEAVDSGL---------A 674

  Fly   836 AVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEE 900
            |:..|:...::..|       ..|:.||...||..::|:               .||.:||::..
Mouse   675 ALRDTNRHLELKDN-------ELRLKKKELLERKTRKRQ---------------LEQKISSKLAS 717

  Fly   901 IQ-NQYDTLR-NESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADR--------NITKITGNN 955
            |: .:.||.. .|..:....|||::|.|..||...:..| |.:.|:.:        ..|.:....
Mouse   718 IRLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTGL-VKICTSFQIQKVDLILQNTTVISEK 781

  Fly   956 NNLRENIKAAEEKLK-------SLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDE 1013
            |.|..:..|:..:|:       .|:::|.:..:|.:||.|:
Mouse   782 NKLEADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELMKK------------------------ 822

  Fly  1014 ITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEE 1078
                  .|.:..:..|   ||...:.......||...:...|:...::|...:....|  |.||.
Mouse   823 ------ARQVCNLSAD---QAVPQEFQTQVPTIPNGHSSSPPMAFQDLPNTLDEIDAL--LTEER 876

  Fly  1079 LEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKR---NEMRDKYE 1140
            ..|.....|                |.|.:.|...||.|.:.  ::.|::..|:   :|.|:...
Mouse   877 SRASCFTGL----------------NPSVVVEEYSKREVEIQ--QLTEELQGKKVELDEYRENIS 923

  Fly  1141 EVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISN 1205
            :|::|......:....|..|....:..:...|:.:|...:..|....|:.  :|...:|...:..
Mouse   924 QVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIR--IRVKFRSSTQLHE 986

  Fly  1206 L-----SGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKN-----VSIVGHYIKERTKNAQ 1260
            |     ||||:::|::..:.||......|...:|||:..:|..|     ..:|....||.|....
Mouse   987 LTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYF 1051

  Fly  1261 FIIVSLRVNM 1270
            ||...|..|:
Mouse  1052 FITPKLLQNL 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	37/162 (23%)
		Smc	89..1281	CDD:224117	246/1245 (20%)
		SMC_hinge	618..733	CDD:214944	17/122 (14%)
		ATP-synt_B	<825..904	CDD:304375	15/79 (19%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	23/85 (27%)
Smc5	XP_006527043.1	ABC_SMC5_euk	51..>196	CDD:213244	41/178 (23%)
		Smc	53..1056	CDD:224117	244/1238 (20%)
		ABC_SMC5_euk	<976..1078	CDD:213244	23/86 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900