Protein Alignment glu and Smc5

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001413081.1
• Gene: Smc5 / 226026
• MGIID: 2385088
• Length: 1102
• Species: Mus musculus
• Alignment Length: 1245
• Identity: 246/1245 - (19%)
• Similarity: 461/1245 - (37%)
• Gaps: 299/1245 - (24%)

  Fly    89 ISKIVNRNFKSY-AGEVELGPFHQSFTAIIGPNGSGKSNVIDSM-MFVFGCRANRIRCKRVSTLI 151
            |.:|...||.:| ..||..||   ....|||.||:|||:::.:: :.:.|..|...|..:|...:
Mouse    53 IVRIAMENFLTYDICEVSPGP---HLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFV 114

  Fly   152 HSSSSYPNLRSCSVAVHFKQIVD----KGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLK 212
            .        |.||     |.:|:    :..|       :.|:.....:..|.|::.||.|....|
Mouse   115 K--------RGCS-----KGLVEIELFRTSG-------NLIITREIDVIKNQSFWFINKKPVTQK 159

  Fly   213 DVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQ 277
            .|            ..:...|..:|.::....|:.:. .|...|..:|.:..|::.:.|
Mouse   160 IV------------EEQVAALNIQVGNLCQFLPQDKV-GEFAKLSKIELLEATEKSVGP------ 205

  Fly   278 RVDQLTDDRTEKHN-RCKL---AEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSK 338
                     .|.|. .|:|   .|:| |.||....|..:||:|   :|:               :
Mouse   206 ---------PEMHRYHCELKNFREKE-KQLETSCKEKTEYLEK---MVQ---------------R 242

  Fly   339 LEQYTQEHEACAEELKTHDEGTAALKQSR--AEKETIIRKEIEEYEALVKKREQIKKRLVTVESA 401
            .|:|.|:.|...|. |.|.:....|:..|  .|.|.:    .:|||.:...|:::|:.:..::..
Mouse   243 NERYKQDVERFYER-KRHLDLIEMLEAKRPWVEYENV----RQEYEGVKLIRDRVKEEVRKLKEG 302

  Fly   402 YTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVS-KVTLNEEL 465
            ...:...:|..::||...:.:|::...::::..:..::.|..||..:::::.|:.: .|..||||
Mouse   303 QIPMTRRIEEIDRQRHTLEVRIKEKSTDIKEASQKCKQRQDLIERKDRQIKELQQALTVKQNEEL 367

  Fly   466 EKQQAELTKTTAPL--TEKRLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAETTESRKYETL 528
            ::|: .::.|...:  .:..||.::....|:.:::|...:::..:.: |.|.:.|..:.::.
Mouse   368 DRQK-RISNTRKMIEDLQSELKTAENCENLQPQIDTVTNDLRRVQEE-KALCEGEIIDKQRE--- 427

  Fly   529 KSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLRTEINERSS 593
            |...|:.::|:.:.:||.|.|...                   ||:        |||....:...
Mouse   428 KEMLEKQRRSVSDHITRFDNLMNQ-------------------KED--------KLRQRYRDTYD 465

  Fly   594 VMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVTDNYETASA 658
            .:...|:|..      |.|.....| |:..:......:||| :....:...|...|.::.|....
Mouse   466 AVLWLRNNRD------RFKQRVCEP-IMLTINMKDNKNAKY-VENHISSNDLRAFVFESQEDMEI 522

  Fly   659 AIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYFALRNTLV 723
            .:..:::....|...:...||.:..:..:..:|                |..:..|:..||....
Mouse   523 FLREVRDNKKLRVNAVIAPKISYADKAPSRSLN----------------DLKQYGFFSYLRELFD 571

  Fly   724 CDDLEQG--------TRIAYGRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRT------ 774
            ..|....        ..:..|.||.|      |.||          |.|:.....|:.|
Mouse   572 APDPVMSYLCCQYHIHEVPVGTERTR------ERIE----------RVIQETRLKQIYTAEEKYV 620

  Fly   775 -KTAESAD---SSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRL 835
             ||:..::   ||..|.|..:.:.:..:..|.|  :.:||...:.|:::.:.:||         .
Mouse   621 LKTSVYSNKVISSNTSLKVAQFLTVTVDLEQRR--HLEEQLKEMNRQLEAVDSGL---------A 674

  Fly   836 AVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEE 900
            |:..|:...::..|       ..|:.||...||..::|:               .||.:||::..
Mouse   675 ALRDTNRHLELKDN-------ELRLKKKELLERKTRKRQ---------------LEQKISSKLAS 717

  Fly   901 IQ-NQYDTLR-NESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADR--------NITKITGNN 955
            |: .:.||.. .|..:....|||::|.|..||...:..| |.:.|:.:        ..|.:....
Mouse   718 IRLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTGL-VKICTSFQIQKVDLILQNTTVISEK 781

  Fly   956 NNLRENIKAAEEKLK-------SLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDE 1013
            |.|..:..|:..:|:       .|:::|.:..:|.:||.|:
Mouse   782 NKLEADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELMKK------------------------ 822

  Fly  1014 ITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEE 1078
                  .|.:..:..|   ||...:.......||...:...|:...::|...:....|  |.||.
Mouse   823 ------ARQVCNLSAD---QAVPQEFQTQVPTIPNGHSSSPPMAFQDLPNTLDEIDAL--LTEER 876

  Fly  1079 LEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKR---NEMRDKYE 1140
            ..|.....|                |.|.:.|...||.|.:.  ::.|::..|:   :|.|:...
Mouse   877 SRASCFTGL----------------NPSVVVEEYSKREVEIQ--QLTEELQGKKVELDEYRENIS 923

  Fly  1141 EVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISN 1205
            :|::|......:....|..|....:..:...|:.:|...:..|....|:.  :|...:|...:..
Mouse   924 QVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIR--IRVKFRSSTQLHE 986

  Fly  1206 L-----SGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKN-----VSIVGHYIKERTKNAQ 1260
            |     ||||:::|::..:.||......|...:|||:..:|..|     ..:|....||.|....
Mouse   987 LTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYF 1051

  Fly  1261 FIIVSLRVNM 1270
            ||...|..|:
Mouse  1052 FITPKLLQNL 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	246/1245 (20%)
Smc5	NP_001413081.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		P-loop containing Nucleoside Triphosphate Hydrolases	51..>196	CDD:476819	41/178 (23%)
		SMC_prok_B	196..1054	CDD:274008	202/1057 (19%)
		Flexible hinge	441..644		47/269 (17%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<976..1078	CDD:476819	23/86 (27%)