DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and smcl-1

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_509956.2	Gene:	smcl-1 / 183453	WormBaseID:	WBGene00008085	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	477	Identity:	110/477 - (23%)
Similarity:	196/477 - (41%)	Gaps:	101/477 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   870 VKEREEQIEAAKQELEQAQFAEQAVS-----------SQIEEIQNQYDTLRNE-SVKP----VEA 918
            |.|.|..:|..|...   :||.|.:|           ...||:...:|.:.|. ..||    ::|
Worm   110 VTEEEYLLELGKMNF---RFAGQNISVYNKTTLKVTRKSAEELGAFFDIVSNSIEFKPEYDELKA 171

  Fly   919 KIKKVNSQIEKLAANVRSLNV-----------GLATADRNI--TKITGNNNNLRENIKAAEEKLK 970
            |:....|.:.:.|..:.|:.:           .|...|:.|  ||.......|:.|.|.|:..|
Worm   172 KLNFAESTVLRWAKMIDSIELEKEKFITLTLYKLYLCDKEIQETKEKFVAEQLKVNAKNAKMPL- 235

  Fly   971 SLNEDRNKAKEKKEELEKEIE----ESEASIEGAKSQSS-DIKKEIDEITKEENKRNIERIEIDT 1030
                   :.....|.:.|:..    ::.|.:...|:.:. |....:|::....|::..||.|:
Worm   236 -------RISRYSEAIPKQTPSPNFKNNAIVVRPKTHNHYDNLITVDKLNSYLNEKVTERREL-- 291

  Fly  1031 KLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEEL------EAETLEALQY 1089
             ||.|....|                 :|....|..|....:|::..||      |::.:.|..|
Worm   292 -LQFAVNHPN-----------------MNIRFSEEGPNIYAREIDYTELPEYYKKESDDIIATSY 338

  Fly  1090 KQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRV-LEDITSK-------RNEMRDKYEEVRKRR 1146
            |::|||:::  ||.....:.|.|.|....:|.:.: :::.|:|       .:|.|..:|::|..|
Worm   339 KRSMLEKEI--KKIRQCWLDENNIKDDANIDNINMRIKEATTKHTLALNIESEARLNWEKLRVMR 401

  Fly  1147 YKEFMDGFSIITRKLKEMYQMITLGGD--AELELVDSMDPFTEGVNFTVRPPKKSWKYIS--NLS 1207
            ...|.:..:.:...|..:|..|....|  |.|..:|..:|:. .::..|:  ::..::||  ...
Worm   402 SARFNNFMAPLQTSLSRIYAEIAQDEDSLAFLRPLDEEEPYL-AIDAFVK--ERHSEHISTRTFH 463

  Fly  1208 GGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLRVNMFE 1272
            ||.:.:..|||:||:|.:|||||..:|:||..|..:....:..|: .|.|..|||:.:...:.|
Worm   464 GGSRMIVDLALIFAIHEWKPSPLVVIDDIDRNLYHEASKKIEPYL-SRQKQTQFIVTTKEDSYF- 526

  Fly  1273 LANFLVGIYKVSDCTDSITMLN 1294
                       ::.|.:||:.|
Worm   527 -----------TEVTKTITLEN 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241
		Smc	89..1281	CDD:224117	106/462 (23%)
		SMC_hinge	618..733	CDD:214944
		ATP-synt_B	<825..904	CDD:304375	11/44 (25%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	27/95 (28%)
smcl-1	NP_509956.2	ABC_ATPase	8..>123	CDD:330224	5/12 (42%)
smcl-1	NP_509956.2	SMC_N	<112..520	CDD:330553	104/444 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810