Protein Alignment glu and smc-3

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001255118.1
• Gene: smc-3 / 176559
• WormBaseID: WBGene00004873
• Length: 1205
• Species: Caenorhabditis elegans
• Alignment Length: 1346
• Identity: 285/1346 - (21%)
• Similarity: 547/1346 - (40%)
• Gaps: 301/1346 - (22%)

  Fly    89 ISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHS 153
            |.::....|:||.....:..|......::|.|||||||...::.||.......::.::...|:|.
 Worm     3 IKEVRITGFRSYKDNTNVSGFSPRSNVVVGRNGSGKSNFFHAIQFVLSDEYAHLKEEQRLGLLHE 67

  Fly   154 SSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKLL 218
            |:. |.:....|.:.|    |..:.......:|.:.|.|........|| |::|.....:|..|:
 Worm    68 STG-PKVAHARVEITF----DNSEKRLMAFENSEVKIVRQVGKKKDQYY-IDNKMVPRAEVVNLM 126

  Fly   219 KKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQLT 283
            :.......:..:::.||::..:|       |..:...|:.|.::.||:.|
 Worm   127 ESAGFSRSNPYYIVKQGKINELA-------TSPDAYKLKLLREVAGTRVY--------------- 169

  Fly   284 DDRTEKH----NRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSKLEQYTQ 344
            |:|.|:.    ...|:...:::.|.:..:|.:..|:.|.|.::    ..||:...|:|  .:||.
 Worm   170 DERKEESLKILKETKMKTEKIQGLLKYIDERLQTLENEKEDLK----EYQKLDKTKRS--VEYTM 228

  Fly   345 ----EHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEI 405
                ..||..|:.|. ||....|.|    |:..::.::.:..|.:.|.:..||:|.::.....|.
 Worm   229 YDNTNKEAIKEKTKL-DEQKVELNQ----KDNNVKSQLNDVIAEMAKLKTDKKKLESLGRGLRED 288

  Fly   406 QSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSKVTLNEELEKQQA 470
            :.|:     |.::.|...||...:|| :..|.|:|.||    .:..::.|.|...:.:|:.|.:.
 Worm   289 KETL-----QAEETKMVEEKMTLKLE-IDSLNEENTRE----RQGRQNAEHSLQGVGDEIFKNEE 343

  Fly   471 ELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQLK--ILKQAETTESRKYETLKSSYE 533
            || .|..|          |...|.|:.:..|.::::.||:.|  :.||.:.::.       ||.:
 Worm   344 EL-DTIKP----------EYAKLLEEESRLKTDIRIDESRAKEILAKQGQRSQF-------SSVD 390

  Fly   534 QSQKSLEEKVTRVDEL----KESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLRTEIN----E 590
            ...|.|..::.|:..|    ||....::.|:|....|.:|:..|.:::|...::.|.|::    :
 Worm   391 DRDKFLRNEIRRISGLIADNKEREETIQKELADVEREDEKLNNEIQSISRTIDENRYEMDTFAAK 455

  Fly   591 RSSVMQ-----------AQRSNNKVLDFLMRMKME-----GKIPGILGR--LGDLGGI-----DA 632
            .:|:.|           |.|....:.|.:...:.:     .::..|:.|  ...:.|:     :.
 Worm   456 STSLKQEYDAAYVAQQTAAREEKAIRDKIGNTEQDISAANDQLRRIVARPVYNGITGVRKVIEEF 520

  Fly   633 KYDIAISTACGRLDNIVTDNY------------------------------ETASAAIGALKEYN 667
            |:|    ...|:.|:::...|                              ||...|...|:::|
 Worm   521 KHD----NRNGQHDDVINGYYGTVIELAEVPDMFRTAVEVIAQNRLFYHVVETDRIATKILRKFN 581

  Fly   668 ----VGRATFITLDKIEHHRREANSRINTPENVPRLYDLV--KVEDDRVRTAFYFALRNTLVCDD 726
                .|...|..::::...|:.   .::...|...:.|::  :|:.|:|   |.....|.::...
 Worm   582 EMQLPGEINFFPMNRVSAPRQR---DLSNNSNARPMSDVIDYEVQYDKV---FKSITANVIIVRT 640

  Fly   727 LEQGTRIAYGRERYRVVTLRGEMIEMTGTMSGGGSRPIRGK--MGTQVRTKTAESAD---SSQIS 786
            |:|..| ....|.:.||::.|:.:...|.|:||.....|.|  :.||....|.|.|:   |...:
 Worm   641 LDQAAR-DLRNEGFDVVSVDGDQMSKKGVMTGGFIDKKRSKLELHTQKDRFTKELAELQKSLAEA 704

  Fly   787 QKALEDMQIQAEELQARVNYCQEQQGSL---EREIQTLKNGL-------------QRDEA----- 830
            :|.:.:...:||:::.|:...:.|.|..   .||:...||.:             ::|:.
 Worm   705 EKMVRERTQEAEKIRNRMQQHENQIGDFHRKHRELTEAKNAISQQFYMVTSTKEPKKDQLLGIKN 769

  Fly   831 EYKRLAVSITSLEQQMASN----LKQCEAQRQRMLKKTTDE-----RAVKEREEQIEAAKQELE- 885
            ..:.|.....:.||::.||    |...|.|..:.|:|..||     ..|..|...:...|..:|
 Worm   770 HLRELLAQKENFEQEIGSNMSSQLTSDEEQTVKKLRKKVDEMTKQLATVSRRRMDLMHRKNAIEN 834

  Fly   886 ----QAQFAEQAVSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADR 946
                :....::::::::::|.:      ||.    ..|::..|:|:..|...:.|....||||
 Worm   835 LLTKKLYKTKESLTARVDDISD------NER----RHKLENANAQLTSLLTRMESTRKQLATA-- 887

  Fly   947 NITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEI 1011
                        ...::..|.|.|:|..:.:...|::.:|||              |.:|.:.:.
 Worm   888 ------------ISELQDYETKEKALQINIDNVLEQQRDLEK--------------QQADFQLQY 926

  Fly  1012 DEITKEENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNE 1076
            |:||.:|:       |:..|.:.:..||.                .|..:|  |:..:..:.:..
 Worm   927 DKITAKED-------EVKQKREDSLKKMR----------------LLGALP--TDTFSKWQNVKP 966

  Fly  1077 EELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRL-VYLDRVRVLEDITSKRNEMR---D 1137
            .|||.:.||.:        .:|| |..|:      |:|.| .|:......|::|.:..|.:   |
 Worm   967 RELEKKLLECV--------NELK-KYENV------NKKALDQYMTASSQKEELTKRMAEQKKSED 1016

  Fly  1138 KYEEVRK----RRYKEFMDGFSIITRKLKEMYQMITLGGDAELEL-----------VDSMDPFTE 1187
            ..||:.|    |:|:.....|..:.:..:::::.:...|..::::           ::|::.: |
 Worm  1017 SIEELLKVLENRKYEAIDLTFKQVKKNFEQVFKQLVPHGRGKMQMRAREQRDDEEGINSVELY-E 1080

  Fly  1188 G----VNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIV 1248
            |    |:|.........:.::.||||:|:|.:||::|::....|:|.|..||||||||.::...|
 Worm  1081 GISVLVSFVSDDGDSETREMTQLSGGQKSLVALAIIFSIQKCDPAPFYLFDEIDAALDAQHRKSV 1145

  Fly  1249 GHYIKERTKNAQFIIVSLRVNMFELANFLVGI---YKVSDCTDSIT 1291
            ...|:..:..|||:..:.|..:...|....|:   .|||. .||:|
 Worm  1146 ADMIQSLSDQAQFVTTTFRPELLATAEKFYGVRFRNKVSH-IDSVT 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	282/1340 (21%)
smc-3	NP_001255118.1	SMC_N	2..1185	CDD:481474	281/1338 (21%)