DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and smc-4

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_497935.1	Gene:	smc-4 / 175603	WormBaseID:	WBGene00004874	Length:	1549	Species:	Caenorhabditis elegans

Alignment Length:	1529	Identity:	467/1529 - (30%)
Similarity:	761/1529 - (49%)	Gaps:	231/1529 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RPSKGTPKAAGGARQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTRIGDIY 69
            :|.|.|.|.....::.               ::..:||...||:..     ||..:|.....|::
Worm    26 KPQKKTTKPVNRHKEG---------------SKDPEEELQRAVNEK-----FDGSDGEDDDSDLF 70

  Fly    70 I--PPPVPPHCSMESTGPRLIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMM 132
            .  .|..|...:..:...||:|..:...|||||.|:..:||||:|||:|||||||||||:|||::
Worm    71 SLQLPSRPDFLTKPNRADRLMIRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLL 135

  Fly   133 FVFGCRANRIRCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSD 197
            ||||.||::||..:||.|||.|:. .|...|:|.:||::|||. .|..|.|.||...|.|||..:
Worm   136 FVFGFRASKIRSAKVSNLIHKSAG-RNPDKCTVTIHFQRIVDI-PGHYEVVKDSEFTISRTAFQN 198

  Fly   198 NSSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDI 262
            |||.|.|:.:.|...:|...|::..:|:|||||||||||||.||||||...|::||||:||||||
Worm   199 NSSSYAIDGRPATKNEVEARLRRVDIDIEHNRFLILQGEVEQIAMMKPVKTTKSETGMVEYLEDI 263

  Fly   263 VGTQRYIRPLQQINQ-RVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELV----- 321
            :||.| :.|..::.| ||::||.|.:::......|......:|.|...|:::|.||||..
Worm   264 IGTNR-LEPFVKLFQRRVNRLTCDLSQQRIARDHARNSKVAMENPVRAAIEFLMKENEATTIHMK 327

  Fly   322 ---RTKSFHIQKIISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEA 383
               |.:..::.| |:.|:::|::..:|.::.||.|.|:..   ..|||...::.:    |||...
Worm   328 LEQRRRQRYLDK-IAPKQAELDKMKEEMKSIAETLDTNKN---EYKQSEEAQKVM----IEERSK 384

  Fly   384 LVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCN 448
            |.|..:.:.|.|..:.:..|..:..::.......|.:|:.||..|:..:|...|||.:|:|..|.
Worm   385 LDKNFDSLSKELSDLGTEETRRKEALKRHQANISKAEAEKEKEVKKRSNLEAAPEKAERKIAKCQ 449

  Fly   449 KKLES-LEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQLK 512
            :::|. ||:.| |.|||.:|...|..|.:....|::.|:.:.......:.|..:||.::.....:
Worm   450 EEVEQLLEIEK-TANEEADKNLDEFEKRSEAPKEEQKKIQETWAQKSNEFNKVRGEARIAREDFE 513

  Fly   513 ILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNL 577
            .||:...:.:.|...||...|.|::|..::...:|:||........::...|.|:..:    ||.
Worm   514 DLKKLANSGTDKLIELKKRLESSEESYAKEKDELDKLKPEFDSWNDKLKQLSTELPTL----RNT 574

  Fly   578 SMQCNKLRTEINERSSVMQAQR----SNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAI 638
            :.|.|:...:..:|...::.|.    |:|||:..||:.|..|:|....|||||||.||.||:.||
Worm   575 ARQKNQDLAKTRDRLETLRQQNSSCSSSNKVIQALMKEKEAGRIKSFHGRLGDLGVIDPKYEGAI 639

  Fly   639 STACG-RLDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDL 702
            .|..| ||:.::....|.|...|..|....:.|.|...||||:..:|:.......|...|||.||
Worm   640 CTNFGARLNYLIVGKEEDAKNVINFLVANKLPRQTVQPLDKIKCDKRDLAPNPTNPLPAPRLIDL 704

  Fly   703 VKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYGRERYR--------VVTLRGEMIEMTGTMSGG 759
            :.. |..::.|||..:|:.:|.|..::..|:      :|        |.||.|.||..:|:.:||
Worm   705 IDC-DPVLKPAFYDMVRSAIVGDSTQEAQRM------HRMPACRGVTVCTLEGSMIHPSGSFTGG 762

  Fly   760 GSRPIRG-------KMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLERE 817
            | :.::|       ||..||..:  :.|....:::| |..::.:|:||:.:.:....|.....|:
Worm   763 G-KTVKGLILTDKNKMAKQVTPE--DKAAERDLAEK-LGKLRDEADELKGQEHEMDGQLIEARRK 823

  Fly   818 IQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQ 882
            :..:.|.|....:..:..|.:|.:|::.:|:..|  ||.:.::..||.:::  ::..|::|..:.
Worm   824 VAEMSNRLSIVTSSVQSAAPAIETLKKTIANQEK--EAAKVKVDAKTLEDK--QKIVEELEKKRD 884

  Fly   883 ELEQAQFAEQA--VSSQIEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATAD 945
            ||     .|:|  |.::..|||::.|.:..|.|:....:.|:...:.:||              :
Worm   885 EL-----GEEAAKVKARQAEIQSKLDGIFKELVQCHRDEAKESLQKRQKL--------------E 930

  Fly   946 RNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEEL-EKEIEESEA-----SIEGAKSQS 1004
            ::|.|.|.|.:|...||...:|.:...::|..|.|:|.||| ||.|::.|.     ::|..:.|.
Worm   931 KDIAKETANISNSGRNIAKCDENISRHDKDIEKMKKKCEELMEKAIDDEEVKSKKETVERFEKQI 995

  Fly  1005 SDIKKEIDEITKEENKRNIERIEIDTKLQAAAGKMNKVKND-------IPGWQAQLAPLKLNEIP 1062
            ..::.:.:|:||::::.:....:::.:|:..:..:.::|..       :...:.:||.||:|.||
Worm   996 KKLQTKGEEMTKKQSELSAAETKLEGELKKCSEGIKELKESMLADRLKVEDIEKKLAALKVNRIP 1060

  Fly  1063 G---------------------------------------------------------------- 1063
            .
Worm  1061 RFQFLIESSRPEDLEMQIDDKMPVVDENQSPEEVERQKKHMACVMSDAAYALEFEMRQKVLENTE 1125

  Fly  1064 -----ETEPQAPLKELNEE---ELEAETLEALQYKQTMLEEDLKT--KKPNLSCIKEFNEKRLVY 1118
                 :.|.:.|::.|::|   |:.:...|.:|.|..:.|:.::.  .|.::|.||.:.:|...|
Worm  1126 SYENVDGEDRVPVELLSDEKINEISSRDAEEMQMKLKVCEQQVEALKAKVDISSIKAYVDKVKQY 1190

  Fly  1119 LDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSMD 1183
            .::|..|...|....:...:.:.:::.|.:||...|..|.:.|..:::|:|.||||:||.:|..|
Worm  1191 NEQVIKLTIATEVHRKHNQELQRIKQMRLEEFHSAFEFIGKHLVAVFKMLTDGGDAKLEYIDKDD 1255

  Fly  1184 PFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIV 1248
            ||.:|::|.|||.||:||.|..|||||||||||||:||||.::|:|.|.|||||||||::||||:
Worm  1256 PFRQGISFMVRPAKKAWKQIQFLSGGEKTLSSLALIFALHMFRPTPFYVMDEIDAALDYRNVSII 1320

  Fly  1249 GHYIKERTKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDSITMLNYPP---------------- 1297
            ..|::::|:||||||:|||.|||||||.|||||||..||.::.:   .|
Worm  1321 AQYVRQKTENAQFIIISLRNNMFELANRLVGIYKVDGCTRNVAI---DPLRVCEMAKQITDSLGQ 1382

  Fly  1298 ---TLPTQSPVVANSQYVGGTIEGDN--TIAAENQDDTPTKKSQSPPSEQIV----RLISEL--- 1350
               |||.:.     :|....|:...|  .||.|.|.......::...:|:||    |:..||
Worm  1383 ATCTLPDEV-----TQRFNETMSRQNKEMIAQEKQYPNFPSSNEISKAEKIVNVEGRVRKELIQT 1442

  Fly  1351 GRDTTFAPPLESTVRDTILAQNLKQAATEVAAQP 1384
            .||.|..|..::|..    ....::.|:..|::|
Worm  1443 TRDVTSRPQSKATTS----GDGTERPASRSASRP 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	87/158 (55%)
		Smc	89..1281	CDD:224117	420/1310 (32%)
		SMC_hinge	618..733	CDD:214944	41/115 (36%)
		ATP-synt_B	<825..904	CDD:304375	20/80 (25%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	65/93 (70%)
smc-4	NP_497935.1	ABC_SMC4_euk	90..>252	CDD:213241	89/163 (55%)
		SMC_N	91..1361	CDD:280601	426/1319 (32%)
		SMC_hinge	618..734	CDD:284001	42/116 (36%)
		MCP_signal	865..1037	CDD:304920	44/192 (23%)
		ABC_SMC4_euk	<1261..1362	CDD:213241	69/100 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164170
Domainoid	1	1.000	589	1.000	Domainoid score	I102
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I518
Isobase	1	0.950	-	0	Normalized mean entropy	S1360
OMA	1	1.010	-	-		QHG54018
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	1	1.000	-	-		FOG0003579
OrthoInspector	1	1.000	-	-		otm14211
orthoMCL	1	0.900	-	-		OOG6_101113
Panther	1	1.100	-	-	LDO	PTHR43939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1354
SonicParanoid	1	1.000	-	-		X3446
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750