Protein Alignment glu and dpy-27

DIOPT Version :9

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_497771.1
• Gene: dpy-27 / 175492
• WormBaseID: WBGene00001086
• Length: 1469
• Species: Caenorhabditis elegans
• Alignment Length: 1430
• Identity: 423/1430 - (29%)
• Similarity: 681/1430 - (47%)
• Gaps: 304/1430 - (21%)

  Fly    35 RAQQQQEE----EDAA-------VDALDDALIFDDEEGGTRIGDIYIPPPVPPHCSMESTGPRLI 88
            |.:|..|:    :|.:       ::|.::.:.:|::|.   :.::.|||......| :..|.|:|
 Worm    32 RRRQYMEQLNIFDDVSSGAYMLELEAAENGVKYDEKED---LLNVQIPPKYEDQIS-DPDGNRMI 92

  Fly    89 ISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHS 153
            |..|...|||||||:..|||||::.|.|:||||||||||||:::||||.:|.:||.|::|.||:|
 Worm    93 ILNIYVENFKSYAGKHILGPFHKNLTMILGPNGSGKSNVIDALLFVFGFKAGKIRTKKLSALINS 157

  Fly   154 SSSYPNLRSCSVAVHFKQIVD---KGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVA 215
            ..:|   .||||.:.|:.:.|   :.....|.:.|:.:.|.||...:|:|.|:|:||.|..|||.
 Worm   158 GGNY---ESCSVTIMFQMVKDMPVENYDKYEVLTDNCVCITRTINRENNSKYRIDDKDASQKDVQ 219

  Fly   216 KLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVD 280
            :||.:..:|:.||||||||||||:||:|||..:..||.|||||:||||||.|::.|:.::..||.
 Worm   220 ELLLRAGIDMTHNRFLILQGEVEAIALMKPTSKNPNEEGMLEYIEDIVGTNRFVAPISKLMHRVS 284

  Fly   281 QLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSKLEQYTQE 345
            .|....::.....:..|..:|..|:.....:.||...|.|...:...:                :
 Worm   285 LLEHKSSQYGASVRRHEGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRV----------------K 333

  Fly   346 HEAC--AEELKTHDEGTAALKQSRAEKETIIRK--EIEE-YEALVKKREQIKKRLVTVESAYTEI 405
            |..|  ||.:             |..|.:::.:  |:|| .:.:::.:::::|: .|.|.:...|
 Worm   334 HNLCRYAETM-------------RDAKMSLVTRTGELEENKDIMLEAKDEVRKK-ETHERSLNSI 384

  Fly   406 QSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKL------------------- 451
            .:.:||     |:...|.:||     |.|....|.::.::.|.:.|
 Worm   385 VTELEN-----KRIDWQSKKN-----DWHARDAKRKQGLKSCTQDLGKLMKERDEARREKFEIET 439

  Fly   452 --ESLEVSKVTLNEELE--KQQAELTKTTAPLTEKRL------------------KLSDELVGLK 494
              |:..:||..:..|.:  |:|..:.:.||  ||..:                  ||||||:
 Worm   440 APENARISKQNMQLEWDQLKEQENVCQRTA--TENLIKYDQKSSADRAKHDDLEKKLSDELL--- 499

  Fly   495 EKVNTAKGEVQVFESQLKILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTE 559
             :...||.|:.|.||:||              .:....||.||       ||||||.::..|..|
 Worm   500 -QSMRAKAELDVSESELK--------------DMTIMMEQGQK-------RVDELKGTLQTMMAE 542

  Fly   560 IASKSAEVDKMVKEERNLSMQCNKLRTEINERSSVMQAQRSNNKVLD------------------ 606
            ....:.|::.:..|.::..::.:|...::....|..|..||....||
 Worm   543 NIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKSTEQLLRSKKYELDQEVIEASNTQEVTYRHQA 607

  Fly   607 --FLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTA-CGRLDNIVTDNYETASAAIGALKEYNV 668
              .|..:|..|..||..||||||..|..|:|.||||. ..:||..|....:.....||...||.:
 Worm   608 TAKLHELKEAGLFPGFKGRLGDLASIPIKFDTAISTVFFAQLDYHVVQTSDECRIGIGFCHEYKL 672

  Fly   669 GRATFITLDKIEHHRREANSRINTPENVP--RLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGT 731
            .|.||:.||   |.:....|.:::....|  ||:|.:...:..:|..|||.:.:.||.|.||:.|
 Worm   673 PRTTFVFLD---HLKDTDTSGMDSTMKFPAERLFDKIHCVNPEIRREFYFLIHDILVVDSLEEAT 734

  Fly   732 RI--AY-GRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKM--GTQVRTKTAESADSSQI------ 785
            ||  .| ||.||  .||.|.::..:|.::||| :|..|::  .........:..|.|::
 Worm   735 RIDKKYPGRHRY--CTLNGSILNRSGALTGGG-KPTTGRIRNDNNPNMSGVKKVDLSKLRAAQEK 796

  Fly   786 SQKALE---DMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQMA 847
            ...|||   .:|::.||::|       ..|.:.::::..|..|.....|.|   ..|..|:..:|
 Worm   797 HNHALEAHLKLQLKQEEIRA-------DNGPIIKQLEIRKRELIMSTKEQK---TRIAELKSSIA 851

  Fly   848 SNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRNES 912
            ::.::....|:..::...::||      ||...|:::|::|.:...:..|||:.:.:.|.:..|.
 Worm   852 AHERRMVNYREVTVEDLDEKRA------QIADLKRQVEESQKSSAKIKQQIEQYKRKMDRMFMEL 910

  Fly   913 VKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLN---- 973
            |:..:..|::...::.:|              :::|.:.|....|...:::.||:||..|.
 Worm   911 VQKNKDSIEQAKDRMGQL--------------EQDIARQTAIIENNPSHLEQAEKKLSELEHMCL 961

  Fly   974 EDRNKAK-----EKKEE------LEKEIEESEASIEGAKSQSSD--------------------- 1006
            |.|::|.     |..|:      :..:::.|.|||:..:::.::
 Worm   962 EKRSEADALAQLEVGEDVKGIDIINAQLQTSTASIDAQRARYTEAVAARREADAAYQTTVDNYNM 1026

  Fly  1007 IKKEIDEITK----EENKRNIERIEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGE--- 1064
            :|:..||:.:    .|||...:..|:|. :::|             |   :.|.||.. ||:
 Worm  1027 VKQTYDELMRIIDDLENKTMADNAELDI-IESA-------------W---MQPEKLYP-PGKFVR 1073

  Fly  1065 -TEPQ-----------APLKELNEEELEAETLEALQYKQTMLEEDLKTKKPNLSC---------I 1108
             .:|.           .|.:.::..|...|..|  :::..|||:|:.....|..|         .
 Worm  1074 YNDPDIAAKMTDGHVVLPYECISMIEPHREAYE--EHEARMLEDDVFEDTANKICKLEKDVDKFR 1136

  Fly  1109 KEFNEKRL--------VYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMY 1165
            :||:.|.:        :.::.|...:..:.|....|:|..|:|..|:.||.:..:.:....:.:|
 Worm  1137 REFDNKGVRDYAMIVSLLMNEVTSAKKFSDKLKAHREKLNELRMARFNEFSEALAFLGTTTQMLY 1201

  Fly  1166 QMITLGGDAELELVD---SMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYKP 1227
            |:||.||||.|:.|:   |.|||..|:.|:|||.|||||.|.|||||||||:||..|||:|:|:|
 Worm  1202 QLITNGGDASLKFVEEGKSTDPFDGGIKFSVRPAKKSWKLIENLSGGEKTLASLCFVFAMHHYRP 1266

  Fly  1228 SPLYFMDEIDAALDFKNVSIVGHYIK--ERTKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDSI 1290
            :|||.|||||||||..|||::.:|||  |||:||||||:|||..|||:.|.|:||||:...|.:|
 Worm  1267 TPLYVMDEIDAALDLNNVSLIANYIKHSERTRNAQFIIISLRNQMFEVGNRLLGIYKIDGKTYNI 1331

  Fly  1291  1290
             Worm  1332  1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	82/161 (51%)
		Smc	89..1281	CDD:224117	404/1354 (30%)
		SMC_hinge	618..733	CDD:214944	43/117 (37%)
		ATP-synt_B	<825..904	CDD:304375	17/78 (22%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	63/95 (66%)
dpy-27	NP_497771.1	Smc	91..1322	CDD:224117	405/1356 (30%)
		P-loop_NTPase	91..>247	CDD:304359	80/158 (51%)
		SMC_hinge	620..736	CDD:284001	43/118 (36%)
		P-loop_NTPase	<1235..1331	CDD:304359	63/95 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1360
OMA	1	1.010	-	-		QHG54018
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	1	1.000	-	-		FOG0003579
OrthoInspector	1	1.000	-	-		otm14211
orthoMCL	1	0.900	-	-		OOG6_101113
Panther	1	1.100	-	-	O	PTHR43939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1354
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.700