Protein Alignment glu and Smc2

DIOPT Version :9

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001288341.1
• Gene: Smc2 / 14211
• MGIID: 106067
• Length: 1191
• Species: Mus musculus
• Alignment Length: 1328
• Identity: 313/1328 - (23%)
• Similarity: 562/1328 - (42%)
• Gaps: 279/1328 - (21%)

  Fly    87 LIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFG-CRANRIRCKRVSTL 150
            :.:..|:...|||||...|:..|...|.||.|.|||||||::||:.|:.| ...:::|...:..|
Mouse     1 MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly   151 IHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVA 215
            ::.:.. ..:...||::.|.. .||............|.:.|..:....:.|.||...|....|.
Mouse    66 VYKNGQ-AGITKASVSITFDN-SDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQ 128

  Fly   216 KLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVD 280
            .|.....:::.:..|||:||.:..:..|||       ..:|..:|:..||:.|         ...
Mouse   129 DLFCSVGLNVNNPHFLIMQGRITKVLNMKP-------PEILSMIEEAAGTRMY---------EYK 177

  Fly   281 QLTDDRTEKHNRCKLAEREMKD-LEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSKLEQYTQ 344
            ::...:|.:....||  :|:|. ||:.....:..||:|    |:.....||::    .::|..::
Mouse   178 KIAAQKTIEKKEAKL--KEIKTILEEEITPTIQKLKEE----RSSYLEYQKVM----REIEHLSR 232

  Fly   345 EH------------EACAEELKTHDEGTAALKQSRAEKETIIRK---EIEEYEALVKKREQIKKR 394
            .:            |..|.|||...:....|::..:|.|..|:.   ||||.|.  :|.::...:
Mouse   233 LYIAYQFLRAEDTKERSAGELKEMQDKIVNLQEVLSENEKKIKALNCEIEELER--RKDKETGGK 295

  Fly   395 LVTVESAYTEIQSTMENTNKQ-----RKKDKAQIEKNEKEL-----EDLHKLPEKNQREIEDCNK 449
            |.::|.|..|.|..  ||..|     :||:.|..|...|||     ||...|..| ::|::....
Mouse   296 LKSLEDACAEAQRV--NTKSQSAFDLKKKNLASEETKRKELQNSMAEDSKALAAK-EKEVKKITD 357

  Fly   450 KLESLEVSKVTLNEELEKQQAELTKTTAPLTEK----RLKLSDELVGLKEKVNTAKGEVQVFESQ 510
            .|..|:.:.....|.|...|......:|.|:..    ...|:.:::..|..::.|:.|.:..:.:
Mouse   358 GLHGLQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMIACKNDISKAQTEAKQAQMK 422

  Fly   511 LKILKQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAE---VDKMVK 572
            ||..:|...::..:.:.:.|.|::.|.:.|       .:|::..:::||:...:.|   .:|:::
Mouse   423 LKHAQQELKSKQAEVKKMDSGYKKDQDAFE-------AVKKAKEKLETEMKKLNYEENKEEKLLE 480

  Fly   573 EERNLSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKME----GKIPGILGRLGDLGGIDAK 633
            :.|.||...|.|:    .:...:.|:..|   |.|..:...:    ..:.|::..|  :...|..
Mouse   481 KHRQLSRDINNLK----GKHEALLAKFPN---LQFAYKDPEKNWNRNSVKGLVASL--INVKDNS 536

  Fly   634 YDIAISTACG-RLDNIVTDNYETASAAI--GALKEYNVGRATFITLDKIE------HHRREANSR 689
            ...|:....| ||.|:|.|...||...:  |.||.    |.|.|.|:||.      ...|.|.:.
Mouse   537 TATALEVVAGERLYNVVVDTEVTAKKLLEKGELKR----RYTIIPLNKISARCIAPETLRVAQNL 597

  Fly   690 INTPENVPRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYG-RERYRVVTLRGEMIEMT 753
            :. |:||.....||..:.: ::....|....|.||::::...::|:. |...|.|||.|::.:..
Mouse   598 VG-PDNVHVALSLVDYKPE-LQKGMEFVFGTTFVCNNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660

  Fly   754 GTMSGGGS-------------RPIRGKMGT---QVRTKTAESADSSQISQK---ALEDMQIQAEE 799
            ||:|||..             :.::.::.|   ::|....|.|....:::|   ..:..:::.||
Mouse   661 GTLSGGARSQAASILTKFQEVKDVQDELRTKENELRALEEELAGLKNVAEKYRQLKQQWEMKTEE 725

  Fly   800 ---LQARVNYC-----QEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQMASNLKQCEAQ 856
               ||.::...     ||:..:|::.|:..:..|:..:...|:......:||.:|    |..||:
Mouse   726 GDLLQTKLQQSSYHKQQEELDALKKTIEESEETLKSTKEIQKKAEEKYEALENKM----KNAEAE 786

  Fly   857 RQRMLK---------KT---TDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLR 909
            |::.||         ||   ...:.:||:::::||...|||:.: .|.|.:.|      |.|.:
Mouse   787 REKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK-REHASNEQ------QLDAV- 843

  Fly   910 NESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITK----ITGNNNNLRENIKAAEEKLK 970
            ||::|..|       .||||:||.|......:..|...:.|    ||..:|.:::  |.||....
Mouse   844 NEAIKAYE-------GQIEKMAAEVAKNKESVNKAQDELMKQKQIITAQDNIIKD--KCAEVAKH 899

  Fly   971 SL--NEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKLQ 1033
            :|  ||.:.|.||....:.|.                  |:|.|:
Mouse   900 NLQNNESQLKIKELDHSISKH------------------KREADD-------------------- 926

  Fly  1034 AAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDL 1098
             ||.|::|:.:|.....|:      ..:.|:.......|..|.:| ..:.|:.||..:..|..::
Mouse   927 -AAAKVSKMLSDYDWINAE------KHLFGQPNSAYDFKTNNPKE-AGQRLQKLQEVKEKLGRNV 983

  Fly  1099 KTKKPNL--SCIKEFNE----KRLVYLDRVRVL---EDITSKRNE-MRDKYEEVRKRRYKEFMDG 1153
            ..:..|:  ...:.:|:    ||:|..|:.::|   ||:..|:|: :...:::|.    |:|...
Mouse   984 NLRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQALNIAWQKVN----KDFGSI 1044

  Fly  1154 FSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPK---------------KSWK-Y 1202
            ||.:                            ..|.|..:.||:               .:|| .
Mouse  1045 FSTL----------------------------LPGANAMLAPPEGQTVLDGLEFKVALGNTWKEN 1081

  Fly  1203 ISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLR 1267
            ::.||||:::|.:|:|:.::..:||:|:|.:||:|||||..:...:|..::....::|||:|||:
Mouse  1082 LTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLK 1146

  Fly  1268 VNMFELAN------FLVGIYKVSDCTDS 1289
            ..||..||      |:.|:..|:..|.|
Mouse  1147 EGMFNNANVLFKTKFVDGVSTVARFTQS 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	45/159 (28%)
		Smc	89..1281	CDD:224117	310/1316 (24%)
		SMC_hinge	618..733	CDD:214944	32/123 (26%)
		ATP-synt_B	<825..904	CDD:304375	23/90 (26%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	37/116 (32%)
Smc2	NP_001288341.1	Smc	1..1168	CDD:224117	310/1320 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810