DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment glu and SMC2

DIOPT Version :9

Sequence 1:NP_723996.1 Gene:glu / 35001 FlyBaseID:FBgn0015391 Length:1409 Species:Drosophila melanogaster
Sequence 2:NP_001036015.1 Gene:SMC2 / 10592 HGNCID:14011 Length:1197 Species:Homo sapiens


Alignment Length:1329 Identity:313/1329 - (23%)
Similarity:548/1329 - (41%) Gaps:289/1329 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 ISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFG-CRANRIRCKRVSTLIH 152
            |..|:...|||||...|:..|...|.||.|.|||||||::||:.|:.| ...:::|...:..|::
Human     3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDLVY 67

  Fly   153 SSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKL 217
            .:.. ..:...||::.|.....|......:|.| .|.:.|..:....:.|.||...|....|..|
Human    68 KNGQ-AGITKASVSITFDNSDKKQSPLGFEVHD-EITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   218 LKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQL 282
            .....:::.:..|||:||.:..:..|||       ..:|..:|:..||:.|         ...::
Human   131 FCSVGLNVNNPHFLIMQGRITKVLNMKP-------PEILSMIEEAAGTRMY---------EYKKI 179

  Fly   283 TDDRTEKHNRCKLAEREMKD-LEQPFNEAVDYLKKEN------ELVRTKSFHIQKIISIKKSKLE 340
            ...:|.:....||  :|:|. ||:.....:..||:|.      :.|..:..|:.::....:..|.
Human   180 AAQKTIEKKEAKL--KEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLA 242

  Fly   341 QYTQEHEACAEELKTHDEGTAALKQSRAEKETIIR---KEIEEYEALVKKREQIKKRLVTVESAY 402
            :.|:...  |||||...:....|::..:|.:..|:   .||||.|.  :|.::....|.::|.|.
Human   243 EDTKVRS--AEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK--RKDKETGGILRSLEDAL 303

  Fly   403 TEIQSTMENTNKQ-----RKKDKAQIEKNEKEL-----EDLHKLPEKNQREIEDCNKKLESLEVS 457
            .|.|..  ||..|     :||:.|..|...|||     ||...|..| ::|::.....|.:|:.:
Human   304 AEAQRV--NTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAK-EKEVKKITDGLHALQEA 365

  Fly   458 KVTLNEELEKQQAELTKTTAPLTEK----RLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAE 518
            .....|.|...|......:|.|:..    ...|:.:::..|..::.|:.|.:..:.:||..:|..
Human   366 SNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQEL 430

  Fly   519 TTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNK 583
            ..:..:.:.:.|.|.:.|::||    .|..|||.:.....::..:..:.:.::::.|.||....:
Human   431 KNKQAEVKKMDSGYRKDQEALE----AVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGR 491

  Fly   584 LRTEI--------NERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAIST 640
            |:...        |.|.:....:::.|:           ..:.|::..|  :...|.....|:..
Human   492 LKETYEALLARFPNLRFAYKDPEKNWNR-----------NCVKGLVASL--ISVKDTSATTALEL 543

  Fly   641 ACG-RLDNIVTDNYETASAAI--GALKEYNVGRATFITLDKIE------HHRREANSRINTPENV 696
            ..| ||.|:|.|...|....:  |.||.    |.|.|.|:||.      ...|.|.:.:. |:||
Human   544 VAGERLYNVVVDTEVTGKKLLERGELKR----RYTIIPLNKISARCIAPETLRVAQNLVG-PDNV 603

  Fly   697 PRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYG-RERYRVVTLRGEMIEMTGTMSGGG 760
            .....||:.:.: ::.|..|....|.|||:::...::|:. |...|.|||.|::.:..||:|||.
Human   604 HVALSLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGA 667

  Fly   761 SRPIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGL 825
            .     .....:.||..|..|       ..::::|:..||:|           ||.|:..|||..
Human   668 R-----SQAASILTKFQELKD-------VQDELRIKENELRA-----------LEEELAGLKNTA 709

  Fly   826 QR------------DEAEYKRLAVSITSLEQQ--------------------------------- 845
            ::            :||:..:..:..:|..:|                                 
Human   710 EKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYE 774

  Fly   846 -MASNLKQCEAQRQRMLK---------KT---TDERAVKEREEQIEAAKQELEQAQFAEQAVSSQ 897
             :.:.:|..||:|:|.||         ||   ...:.:||:::::||...|||:.:....:...|
Human   775 VLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQ 839

  Fly   898 IEEIQNQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENI 962
            :|.:        ||::|..|       ||||.:||.|......:..|...:||       .:|.|
Human   840 LEAV--------NEAIKSYE-------SQIEVMAAEVAKNKESVNKAQEEVTK-------QKEVI 882

  Fly   963 KAAEEKLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIE 1027
            .|.:..:|:...:..|.||:..:.:.:|:|.:.:|...|.::.|...::.::.|:.:..|.||..
Human   883 TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHL 947

  Fly  1028 IDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQT 1092
            ......|...|.|..|.  .|.:.|    ||.|          :||.....:....:..|    |
Human   948 FGQPNSAYDFKTNNPKE--AGQRLQ----KLQE----------MKEKLGRNVNMRAMNVL----T 992

  Fly  1093 MLEE---DLKTKKPNLSCIKEFNEKRLVYLDRVRVL---EDITSKRNE-MRDKYEEVRKRRYKEF 1150
            ..||   ||..|            ||:|..|:.::|   ||:..|:|: :...:::|.    |:|
Human   993 EAEERYNDLMKK------------KRIVENDKSKILTTIEDLDQKKNQALNIAWQKVN----KDF 1041

  Fly  1151 MDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPK---------------KSW 1200
            ...||.:                            ..|.|..:.||:               .:|
Human  1042 GSIFSTL----------------------------LPGANAMLAPPEGQTVLDGLEFKVALGNTW 1078

  Fly  1201 K-YISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIV 1264
            | .::.||||:::|.:|:|:.::..:||:|:|.:||:|||||..:...:|..::....::|||:|
Human  1079 KENLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVV 1143

  Fly  1265 SLRVNMFELAN------FLVGIYKVSDCT 1287
            ||:..||..||      |:.|:..|:..|
Human  1144 SLKEGMFNNANVLFKTKFVDGVSTVARFT 1172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gluNP_723996.1 ABC_SMC4_euk 87..>246 CDD:213241 47/157 (30%)
Smc 89..1281 CDD:224117 311/1321 (24%)
SMC_hinge 618..733 CDD:214944 33/123 (27%)
ATP-synt_B <825..904 CDD:304375 22/136 (16%)
ABC_SMC4_euk <1196..1290 CDD:213241 36/114 (32%)
SMC2NP_001036015.1 Smc 1..1168 CDD:224117 311/1323 (24%)
ABC_SMC2_euk 1..>172 CDD:213240 51/177 (29%)
Uds1 <193..287 CDD:292096 24/97 (25%)
L_lactis_ph-MCP 252..>465 CDD:115336 55/221 (25%)
SMC_hinge 522..639 CDD:214944 33/124 (27%)
DUF342 <636..777 CDD:302792 30/163 (18%)
DUF4200 740..841 CDD:290574 18/100 (18%)
P-loop_NTPase <1074..1168 CDD:304359 33/93 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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