DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and SMC4

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	NP_001002800.1	Gene:	SMC4 / 10051	HGNCID:	14013	Length:	1288	Species:	Homo sapiens

Alignment Length:	1301	Identity:	516/1301 - (39%)
Similarity:	792/1301 - (60%)	Gaps:	39/1301 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PSKGTPKAAGGARQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTR-IGDIY 69
            |.|||..:....|:.|    |...:.....:..:.|......::...|.....||...| :.:|.
Human     2 PRKGTQPSTARRREEG----PPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEEIL 62

  Fly    70 --IPPPVPPHCSMESTGPRLIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMM 132
              ||||.||..:.|:..|||:|:.|||:||||||||..|||||:.|:.||||||||||||||||:
Human    63 NSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSML 127

  Fly   133 FVFGCRANRIRCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSD 197
            ||||.||.:||.|::|.|||:|..:.:::||:|.|||::|:||.....|.:|:|:..:.|||..|
Human   128 FVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRD 192

  Fly   198 NSSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDI 262
            |:|.|.|:.|:...|||..||:.|.:||:||||||||||||.|||||||||||::.|||||||||
Human   193 NTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDI 257

  Fly   263 VGTQRYIRPLQQINQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFH 327
            :|..|...|::.:.:||:.|.:.|.||.||.|:.|:|...||...|.|:::|..|||:.|.|: |
Human   258 IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKN-H 321

  Fly   328 IQK--IISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQ 390
            :.:  |..::|...|..||: |...|:.|..:|.:..|......|...::...::...:.|..|:
Human   322 VCQYYIYELQKRIAEMETQK-EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEE 385

  Fly   391 IKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLE 455
            .|::...::....:::..:::...:.||.:.|::|:::::|:...:|.|:...|.:...:..:||
Human   386 NKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALE 450

  Fly   456 VSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAETT 520
            ..|....::|::....|.:.|..|.:::.....||:|..:.||.|:.::.|.:|:|.|......|
Human   451 KEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNT 515

  Fly   521 ESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLR 585
            ...:....|.:...:.::|:|:...:.:::..:|:.:.|:..|..|:.|:.:||.|.....:.|.
Human   516 AVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLF 580

  Fly   586 TEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVT 650
            .::.|..|.:...||..||||.:::.|..|:||||.|||||||.||.|||:|||:.|..||.||.
Human   581 QKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVV 645

  Fly   651 DNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFY 715
            |:.:.|...:..||..|:|.||||.|||:....::. :.|.||||.|||:|||||:|:::|.|||
Human   646 DSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKM-TEIQTPENTPRLFDLVKVKDEKIRQAFY 709

  Fly   716 FALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAE- 778
            ||||:|||.|:|:|.||:||.:: |:|||||:|::||.:|||:||||:.::|:||:.:..:.:|
Human   710 FALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEE 774

  Fly   779 --SADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITS 841
              :...||:...:.:.||||.:::|     .:|:...|....:.::|.|::..|..:||
Human   775 EVNKMESQLQNDSKKAMQIQEQKVQ-----LEERVVKLRHSEREMRNTLEKFTASIQRL------ 828

  Fly   842 LEQQMASN--LKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQA--VSSQIEEIQ 902
            :||:...|  :|:.||   .:|....|::..|..||.:.|.|.|.:..  ||:|  |.::::.:.
Human   829 IEQEEYLNVQVKELEA---NVLATAPDKKKQKLLEENVSAFKTEYDAV--AEKAGKVEAEVKRLH 888

  Fly   903 NQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEE 967
            |....:.|..:|..:.|:.|:|.|:::.|:.:....|.:.|||||:.|...:.....:.||..|:
Human   889 NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEK 953

  Fly   968 KLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKL 1032
            ::..|..:....::|..|:.|....:|.|:...:.:..::.:|:..|.:.|:....:.:.|..||
Human   954 EVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKL 1018

  Fly  1033 QAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEA-ETLEALQYKQTMLEE 1096
            :...|.:.:..:.|..|..:::.:.|:  |.|..|...:..|:.|:||| :..:::..:..:||.
Human  1019 EQIDGHIAEHNSKIKYWHKEISKISLH--PIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEA 1081

  Fly  1097 DLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKL 1161
            .....||||..|.|:.:|..:||.||..|:.||.:|:..|..||::||:|..|||.||.|||.||
Human  1082 RCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKL 1146

  Fly  1162 KEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYK 1226
            ||.|||:|||||||||||||:|||:||:.|:|||||||||.|.|||||||||||||||||||:||
Human  1147 KENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYK 1211

  Fly  1227 PSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDSIT 1291
            |:||||||||||||||||||||..||.|:||||||||:|||.||||:::.|:||||..:.|.|:.
Human  1212 PTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVA 1276

  Fly  1292 M 1292
            :
Human  1277 V 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	95/158 (60%)
		Smc	89..1281	CDD:224117	488/1202 (41%)
		SMC_hinge	618..733	CDD:214944	65/114 (57%)
		ATP-synt_B	<825..904	CDD:304375	22/82 (27%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	73/93 (78%)
SMC4	NP_001002800.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		11/56 (20%)
		ABC_SMC4_euk	82..>241	CDD:213241	95/158 (60%)
		SMC_N	83..1274	CDD:280601	492/1211 (41%)
		DUF4349	<327..427	CDD:305044	18/100 (18%)
		SMC_hinge	613..727	CDD:214944	65/114 (57%)
		ABC_SMC4_euk	<1181..1275	CDD:213241	73/93 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156327
Domainoid	1	1.000	865	1.000	Domainoid score	I55
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4015
Inparanoid	1	1.050	905	1.000	Inparanoid score	I373
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54018
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	1	1.000	-	-		FOG0003579
OrthoInspector	1	1.000	-	-		oto91397
orthoMCL	1	0.900	-	-		OOG6_101113
Panther	1	1.100	-	-	LDO	PTHR43939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1354
SonicParanoid	1	1.000	-	-		X3446
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800