Protein Alignment glu and SMC4

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_005487.3
• Gene: SMC4 / 10051
• HGNCID: 14013
• Length: 1288
• Species: Homo sapiens
• Alignment Length: 1301
• Identity: 516/1301 - (39%)
• Similarity: 792/1301 - (60%)
• Gaps: 39/1301 - (2%)

  Fly     6 PSKGTPKAAGGARQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTR-IGDIY 69
            |.|||..:....|:.|    |...:.....:..:.|......::...|.....||...| :.:|.
Human     2 PRKGTQPSTARRREEG----PPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEEIL 62

  Fly    70 --IPPPVPPHCSMESTGPRLIISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMM 132
              ||||.||..:.|:..|||:|:.|||:||||||||..|||||:.|:.||||||||||||||||:
Human    63 NSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSML 127

  Fly   133 FVFGCRANRIRCKRVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSD 197
            ||||.||.:||.|::|.|||:|..:.:::||:|.|||::|:||.....|.:|:|:..:.|||..|
Human   128 FVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRD 192

  Fly   198 NSSYYQINDKRAQLKDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDI 262
            |:|.|.|:.|:...|||..||:.|.:||:||||||||||||.|||||||||||::.|||||||||
Human   193 NTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDI 257

  Fly   263 VGTQRYIRPLQQINQRVDQLTDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFH 327
            :|..|...|::.:.:||:.|.:.|.||.||.|:.|:|...||...|.|:::|..|||:.|.|: |
Human   258 IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKN-H 321

  Fly   328 IQK--IISIKKSKLEQYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQ 390
            :.:  |..::|...|..||: |...|:.|..:|.:..|......|...::...::...:.|..|:
Human   322 VCQYYIYELQKRIAEMETQK-EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEE 385

  Fly   391 IKKRLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLE 455
            .|::...::....:::..:::...:.||.:.|::|:::::|:...:|.|:...|.:...:..:||
Human   386 NKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALE 450

  Fly   456 VSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAETT 520
            ..|....::|::....|.:.|..|.:::.....||:|..:.||.|:.::.|.:|:|.|......|
Human   451 KEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNT 515

  Fly   521 ESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLR 585
            ...:....|.:...:.::|:|:...:.:::..:|:.:.|:..|..|:.|:.:||.|.....:.|.
Human   516 AVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLF 580

  Fly   586 TEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVT 650
            .::.|..|.:...||..||||.:::.|..|:||||.|||||||.||.|||:|||:.|..||.||.
Human   581 QKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVV 645

  Fly   651 DNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFY 715
            |:.:.|...:..||..|:|.||||.|||:....::. :.|.||||.|||:|||||:|:::|.|||
Human   646 DSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKM-TEIQTPENTPRLFDLVKVKDEKIRQAFY 709

  Fly   716 FALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAE- 778
            ||||:|||.|:|:|.||:||.:: |:|||||:|::||.:|||:||||:.::|:||:.:..:.:|
Human   710 FALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEE 774

  Fly   779 --SADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITS 841
              :...||:...:.:.||||.:::|     .:|:...|....:.::|.|::..|..:||
Human   775 EVNKMESQLQNDSKKAMQIQEQKVQ-----LEERVVKLRHSEREMRNTLEKFTASIQRL------ 828

  Fly   842 LEQQMASN--LKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQA--VSSQIEEIQ 902
            :||:...|  :|:.||   .:|....|::..|..||.:.|.|.|.:..  ||:|  |.::::.:.
Human   829 IEQEEYLNVQVKELEA---NVLATAPDKKKQKLLEENVSAFKTEYDAV--AEKAGKVEAEVKRLH 888

  Fly   903 NQYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEE 967
            |....:.|..:|..:.|:.|:|.|:::.|:.:....|.:.|||||:.|...:.....:.||..|:
Human   889 NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEK 953

  Fly   968 KLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEIDTKL 1032
            ::..|..:....::|..|:.|....:|.|:...:.:..::.:|:..|.:.|:....:.:.|..||
Human   954 EVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKL 1018

  Fly  1033 QAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEA-ETLEALQYKQTMLEE 1096
            :...|.:.:..:.|..|..:::.:.|:  |.|..|...:..|:.|:||| :..:::..:..:||.
Human  1019 EQIDGHIAEHNSKIKYWHKEISKISLH--PIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEA 1081

  Fly  1097 DLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKL 1161
            .....||||..|.|:.:|..:||.||..|:.||.:|:..|..||::||:|..|||.||.|||.||
Human  1082 RCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKL 1146

  Fly  1162 KEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWKYISNLSGGEKTLSSLALVFALHYYK 1226
            ||.|||:|||||||||||||:|||:||:.|:|||||||||.|.|||||||||||||||||||:||
Human  1147 KENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYK 1211

  Fly  1227 PSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFIIVSLRVNMFELANFLVGIYKVSDCTDSIT 1291
            |:||||||||||||||||||||..||.|:||||||||:|||.||||:::.|:||||..:.|.|:.
Human  1212 PTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVA 1276

  Fly  1292 M 1292
            :
Human  1277 V 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	491/1208 (41%)
SMC4	NP_005487.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		11/56 (20%)
		SMC_N	83..1274	CDD:426784	492/1211 (41%)