Protein Alignment glu and smc1a

DIOPT Version :10

• Sequence 1: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_002935560.1
• Gene: smc1a / 100493711
• XenbaseID: XB-GENE-972620
• Length: 1232
• Species: Xenopus tropicalis
• Alignment Length: 1347
• Identity: 345/1347 - (25%)
• Similarity: 613/1347 - (45%)
• Gaps: 271/1347 - (20%)

  Fly    96 NFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCKRVSTLIHSSS-SYPN 159
            |||||.|...:||||: ||||||||||||||::|::.||.|.:.:.:|.|.:..|||.:. ..|.
 Frog    11 NFKSYKGRQIIGPFHR-FTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGAPVGKPA 74

  Fly   160 LRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKLLKKHHVD 224
            .....|::.:.:  |.|    |:...|.:::      ..||.|:||:|..||.:.:..|:|..:.
 Frog    75 ANRAFVSMVYSE--DSG----EEKVFSRVIV------GGSSEYKINNKVVQLSEYSDELEKLGIL 127

  Fly   225 LEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQLTDDRTEK 289
            ::...||:.||.||||||..||.:|       ...|:|..:....:...:..:.:.:..:|....
 Frog   128 IKARNFLVFQGAVESIAMKNPKERT-------ALFEEISRSGELAQEYDKRKKEMVKAEEDTQFN 185

  Fly   290 HNRCKLAEREMKDLEQPFNEAVDYLKKENELVRT-------KSFH-------IQKIISIKKSKLE 340
            ::|.|....|.|:.:|...||..|.:.::|:.|.       |.:|       :.|.:|:|...:|
 Frog   186 YHRKKNIAAERKEAKQEKEEAERYQRLKDEVARAQVQLQLFKLYHNESEIEKLNKDLSVKNKGIE 250

  Fly   341 QYTQEHEACAEELKTHDEGTAALKQSRAEKETIIRKEIEEYEA--------LVKKREQIKKRLVT 397
            :..:..:...||||...:....:.:    ::..|.|||:|.:|        .:|.:|....::..
 Frog   251 KDKKHMDKVEEELKDKKKDLGKMMR----EQQAIEKEIKEKDAELNQKRPQYIKAKENTSHKIKK 311

  Fly   398 VESAYTEIQSTMENTNKQRKKDKAQIEKNEKELEDLHKLPEKNQREIEDCNKKLESLEVSKVTLN 462
            :|:|    :.:::|..||.||.||.:::.|||:..:    ||.::|.|:             .:.
 Frog   312 LEAA----KKSLQNAQKQYKKRKADMDELEKEMLSV----EKARQEFEE-------------RME 355

  Fly   463 EELEKQQAELTKTTAPLTEKRLK----LSDELVGLKEKVNTAKGEVQVFESQLKILKQAETTESR 523
            ||.:.|..:||     |.|.::|    |.:|   ..::..|...|::.|....|..:.....|.|
 Frog   356 EESQSQGRDLT-----LEENQVKKYHRLKEE---ASKRAATLAQELEKFNRDQKADQDRLDLEER 412

  Fly   524 KYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAEVDKMVKEERNLSMQCNKLRTEI 588
            |....::..:|..:.:||...|:::|:|.|...|..:..:....:.:.:|......:.:::.:|:
 Frog   413 KKVETEAKIKQKLREIEENQKRIEKLEEYIATSKQSLEEQKNLEETLTEEVELAKRRIDEINSEL 477

  Fly   589 NE--------RSSVMQAQRSNNK--VLDFLMRMKMEGKIPG-ILGRLGDL-GGIDAKYDIAISTA 641
            |:        |....::.|...|  :::.:.|:     .|| :.|||.|| .....||.||::..
 Frog   478 NQVMEQLGDARIDRQESSRQQRKAEIMESIKRL-----YPGSVYGRLIDLCQPTQKKYQIAVTKV 537

  Fly   642 CGR-LDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKV 705
            .|: :|.|:.|:.:|....|..:||......||:.||.:|  .:..:.::...:....:.|:::.
 Frog   538 LGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLE--VKPTDEKLRELKGAKLVIDVIRY 600

  Fly   706 EDDRVRTAFYFALRNTLVCDDLEQGTRIAY-GRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMG 769
            |...::.|..:|..|.||||::|...|||: |.:|::.|.|.|.:.:.:|.:|||.|     .:.
 Frog   601 EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGAS-----DLK 660

  Fly   770 TQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKR 834
            .:.|....::.|      |..|..:...|||:.::. .:.::..| |::|:..:|||      .|
 Frog   661 AKARRWDEKAVD------KLKEKKERLTEELKEQMK-AKRKEAEL-RQVQSQAHGLQ------MR 711

  Fly   835 LAVSITSLEQ----QMASNLKQ---CEAQRQRMLKKTTD-ERAVKEREEQIEAAKQELEQA---- 887
            |..|.:.|||    .:|.||::   .|::......:..| :|.::.||.:::..|:::.|.
 Frog   712 LKYSQSDLEQTKTRHLAMNLQEKSKLESELANFSPRINDIKRIIQSREREMKDLKEKMNQVEDEV 776

  Fly   888 --------------QFAEQAVSSQIE------EIQN-------QYDTLRNE------SVKPVEAK 919
                          :|.|:.|..|.|      |.:|       |.|..:|:      .|:..|..
 Frog   777 FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDYEKNQLKEDQGKVQTWEQS 841

  Fly   920 IKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNEDRNKAKEKKE 984
            :||.:::||||                        ....:.::|..:|.:..|.:.:|:...||.
 Frog   842 VKKDDNEIEKL------------------------KKEEQRHMKIIDETMAQLQDLKNQHLAKKS 882

  Fly   985 ELEKE---IEESEASIEGAKSQSSDIKKEIDEI-TKEENKRNIERIEI-------DTKLQAAAGK 1038
            |:..:   :|:....:..|..:.:.::||:..| ||.|.||: :|..:       |.||..:.|.
 Frog   883 EVNDKNHLMEDIRKKLGSANKEVTHLQKEVTAIETKLEQKRS-DRHNLLQACKMQDIKLPLSKGT 946

  Fly  1039 MNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQY-KQTMLE------- 1095
            |:.:..:..|.|                        .||.:.:....:..| |:.:||
 Frog   947 MDDISQEEGGSQ------------------------GEESVSSSQRSSTVYAKEALLEIDYSDLS 987

  Fly  1096 EDLKTK------KPNLSCI-KEFNEKRLVYLDRVRV--------LEDITSKRNEMRDKYEEVRKR 1145
            ||||..      |..:|.: ::.||::.: |.|:..        ||.:..|..|..|::|..|||
 Frog   988 EDLKDAVADDDIKQEMSALHQKLNEQQSI-LQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKR 1051

  Fly  1146 --------------RYKEFMDGFSIITRKLKEMYQMITLGGDAELEL--VDSMDPFTEGVNFTVR 1194
                          |:..|...|..:...:.|:|:.::....|:..|  .:..:|:.:|:|:...
 Frog  1052 AKKAKQAFEQTKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCV 1116

  Fly  1195 PPKKSWKYISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERT-KN 1258
            .|.|.::.:.||||||||:::|||:||:|.|||||.:.:||||||||..|:..|.:||||:: .|
 Frog  1117 APGKRFRPMDNLSGGEKTVAALALLFAIHSYKPSPFFVLDEIDAALDNTNIGKVANYIKEQSMSN 1181

  Fly  1259 AQFIIVSLRVNMFELANFLVGIY-KVSDCTDS----ITMLNYPPTLP 1300
            .|.|::||:...:..|..|:|:| :..||..|    ..:..||...|
 Frog  1182 FQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPDANP 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	340/1328 (26%)
smc1a	XP_002935560.1	SMC_N	3..1210	CDD:426784	339/1327 (26%)