DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment glu and smc2

DIOPT Version :9

Sequence 1:	NP_723996.1	Gene:	glu / 35001	FlyBaseID:	FBgn0015391	Length:	1409	Species:	Drosophila melanogaster
Sequence 2:	XP_002936738.3	Gene:	smc2 / 100486893	XenbaseID:	XB-GENE-5826169	Length:	1202	Species:	Xenopus tropicalis

Alignment Length:	1375	Identity:	319/1375 - (23%)
Similarity:	573/1375 - (41%)	Gaps:	320/1375 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ISKIVNRNFKSYAGEVELGPFHQSFTAIIGPNGSGKSNVIDSMMFVFG-CRANRIRCKRVSTLIH 152
            :..|:...|||||...|:..|...|.||.|.|||||||::||:.|:.| ....::|...:..|::
Frog     3 VKSIIIDGFKSYAQRTEINGFDPLFNAITGLNGSGKSNILDSICFLLGISNLTQVRASNLQDLVY 67

  Fly   153 SSSSYPNLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRAQLKDVAKL 217
            .:.. ..:...:|::.|.. .||............|.:.|..:....:.|.||...|....|..|
Frog    68 KNGQ-AGITKATVSITFDN-YDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   218 LKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQL 282
            .....:::.:..|||:||.:..:..|||       ..:|..:|:..||:.|         ...::
Frog   131 FCSVGLNVNNPHFLIMQGRITKVLNMKP-------PEILAMIEEAAGTRMY---------ECKKI 179

  Fly   283 TDDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENELVRTKSFHIQKIISIKKSKLEQYTQEHE 347
            ...:|.:....||.|.: ..||:.....:..||:|    |:.....|||:...:.....|.....
Frog   180 AAQKTIEKKEAKLKEIQ-TILEEEITPTIHKLKEE----RSSYLEYQKIMREIEHLSRLYIAYQF 239

  Fly   348 AC--------AEELKTHDEGTAALKQSRAEKETIIR---KEIEEYEALVKKREQ--------IKK 393
            .|        |||||...:....|:.:.||.|..::   |||.|.|   |.|:|        :::
Frog   240 VCAEETKVRSAEELKEMQDSILKLQDTMAENERKVKELGKEIAELE---KLRDQEVGGALRSLEE 301

  Fly   394 RLVTVESAYTEIQSTMENTNKQRKKDKAQIEKNEKEL-----EDLHKLPEKNQREIEDCNKKLES 453
            .|...:.:.|::||.:: ..||..|.:   ||..|||     ||...|..| ::|::.....|.|
Frog   302 ALAEAQRSDTKVQSALD-LKKQNMKAE---EKKRKELVKSMEEDAKALTAK-EKEVKKITDSLSS 361

  Fly   454 LEVSKVTLNEELEKQQAELTKTTAPLTE----KRLKLSDELVGLKEKVNTAKGEVQVFESQLKIL 514
            |:.:.....|.|...|......:|.|:.    :...|:.:::..|.:::.|:.|.:..:.:||..
Frog   362 LQETSQKDAEALTGAQQHFNAVSAGLSSNEDGEEATLAGQMMACKNEISKAETEAKQAQMKLKHA 426

  Fly   515 KQAETTESRKYETLKSSYEQSQKSLEEKVTRVDELKESIPRMKTEIASKSAE---VDKMVKEERN 576
            :|...|:..:.:.:.|.|::..::.|       .:|:|..:::.|:...:.|   .::::::.|.
Frog   427 QQELKTKQAEVKKMDSGYKKDNEAFE-------AVKKSKEKLEVEMKKLNYEDGREEQLLEKRRG 484

  Fly   577 LSMQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIP----------GILGRLGDLGGID 631
            ||...|:||    |....:.|:..|         ::.|.|.|          |::..|     |.
Frog   485 LSRDVNRLR----EAYESLMARFPN---------LQFEYKDPEKNWDSSRVKGLVASL-----IS 531

  Fly   632 AKYDIAISTAC-----GRLDNIVTDNYETASAAI--GALKEYNVGRATFITLDKIEHHRREANSR 689
            .| |::.:||.     |||.|:|.|...|....:  |.||.    |.|.|.|:||. .|......
Frog   532 VK-DVSTATALEVVAGGRLYNVVVDTEVTGKKLLEKGELKR----RFTIIPLNKIS-ARCLGKDT 590

  Fly   690 INT------PENVPRLYDLVKVEDDRVRTAFYFALRNTLVCDDLEQGTRIAYGRE-RYRVVTLRG 747
            :|.      .:||.....||..|.: ::.|..:....|||||.::...::.:.|: ..:.|||.|
Frog   591 VNVAKNLVGADNVHLALSLVGYESE-LQKAMEYVFGTTLVCDTMDNAKKVTFDRKIMTKTVTLGG 654

  Fly   748 EMIEMTGTMSGGGSRPIRGKMGTQVRTKTAESADSSQISQKALEDMQIQAEELQARVNYCQEQQG 812
            :..:..||:|||                 |.|.::|.:::  |::::...|||:|:....||
Frog   655 DTFDPQGTLSGG-----------------ARSQNASVLAK--LQELKHVQEELRAKETQLQE--- 697

  Fly   813 SLEREIQTLKNGLQR------------DEAE--YKRLAVSITSLEQQMASNLKQCEAQRQRMLKK 863
             :|:|:.:|||.::|            :||:  ..:|..|....:|:....|||.....:..|||
Frog   698 -VEKELMSLKNTVERYRQLKQQWEMKSEEADLLQTKLQQSSYHKQQEELDTLKQTIEGSEETLKK 761

  Fly   864 TTD----------------ERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYD------ 906
            |.:                :.|..|||.:::.|:|:|:.|:....|.:.:::|.|.:.|
Frog   762 TKEVQMKAEEKFKVLEHKMKNAEAERERELKEAQQKLDGAKKKADASNKKMKEKQQEVDAFVLEL 826

  Fly   907 -------TLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKITGNNNNLRENIKA 964
                   |...:.::.|:..:|....|.:.:|:.|......:..|...:.|       .:|.|..
Frog   827 EELKREQTTYKQQIEVVDEAMKAYQEQADNMASEVAKNKESVKKAQEELAK-------QKEIIMG 884

  Fly   965 AEEKLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNIERIEID 1029
            .::::|:.:.:..|.:|...:|:.:|:|.|.:|...|..|:|
Frog   885 HDKEIKTKSAEAGKLRENNNDLQLKIKELEHNISKHKKDSAD----------------------- 926

  Fly  1030 TKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTML 1094
                 ||.|:.|:.||.. |.|     ....:.|:.......|..|.:| ..:.|:.||.|:..|
Frog   927 -----AAAKVAKMLNDYE-WIA-----SEKHLFGQANTAYDFKTNNPKE-AGQRLQKLQEKKEKL 979

  Fly  1095 EEDLKTKKPNL--SCIKEFNE----KRLVYLDRVRVL---EDITSKRNE-MRDKYEEVRKRRYKE 1149
            ..::..:..|:  ...:.:|:    ||:|..|:.::|   |::..|:|| :...:::|.    |:
Frog   980 GRNVNMRAMNMLTQAEERYNDLMKKKRIVENDKSKILTTIEELDQKKNEALNIAWQKVN----KD 1040

  Fly  1150 FMDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPK---------------KS 1199
            |...||.:                            ..|.|..:.||:               .:
Frog  1041 FGSIFSTL----------------------------LPGANAMLAPPEGQSVLDGLEFKVALGNT 1077

  Fly  1200 WK-YISNLSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYIKERTKNAQFII 1263
            || .::.||||:::|.:|:|:.|:..:||:|:|.:||:|||||..:...:|..::...:::|||:
Frog  1078 WKENLTELSGGQRSLVALSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFRHSQFIV 1142

  Fly  1264 VSLRVNMFELANFLVGIYKVSDCTDSITMLNYPPTLPTQSPVVANSQYVGGTIEGDNTIA--AEN 1326
            |||:..||..||.|   :|..                              .::|.:|:|  |:|
Frog  1143 VSLKDGMFNNANVL---FKTK------------------------------FVDGVSTVARFAQN 1174

  Fly  1327 QDDTPTKKSQ 1336
            |:.:.:...|
Frog  1175 QNGSSSAGQQ 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
glu	NP_723996.1	ABC_SMC4_euk	87..>246	CDD:213241	44/157 (28%)
		Smc	89..1281	CDD:224117	311/1316 (24%)
		SMC_hinge	618..733	CDD:214944	37/137 (27%)
		ATP-synt_B	<825..904	CDD:304375	24/108 (22%)
		ABC_SMC4_euk	<1196..1290	CDD:213241	35/109 (32%)
smc2	XP_002936738.3	Smc	1..1168	CDD:224117	313/1357 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000