DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACADS and Arc42

DIOPT Version :9

Sequence 1:	NP_000008.1	Gene:	ACADS / 35	HGNCID:	90	Length:	412	Species:	Homo sapiens
Sequence 2:	NP_650840.1	Gene:	Arc42 / 42364	FlyBaseID:	FBgn0038742	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	285/409 - (69%)
Similarity:	338/409 - (82%)	Gaps:	6/409 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     4 ALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPA 68
            ::|.|:...|||:|..|....|..      |.||||||.::|||||..||...||:.|:|||:|.
  Fly     3 SVLTRSLCIARRSLNARQIASLSA------LSETHQMLQKSCRDFANNELSGNAAKFDREHLYPE 61

Human    69 AQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSK 133
            .|:::||.||::|:.:||||||.||||:|||||||||||||||.||||||||||||||:|.||:.
  Fly    62 KQIRQMGELGVMAVAIPEELGGTGLDYVAYAIAMEEISRGCASAGVIMSVNNSLYLGPLLSFGND 126

Human   134 EQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVF 198
            .||:.::||||:|:::|||||||||||||||||||.|..:||.:||||||||||||:||.||:||
  Fly   127 AQKKDYITPFTTGERVGCFALSEPGNGSDAGAASTIATDKGDHFVLNGTKAWITNAFEAEAAIVF 191

Human   199 ASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKI 263
            |:|::.|::||||||:||..|.|.:|||||||||||||||..||||||.:||:::|||||.||||
  Fly   192 ATTNKQLKHKGISAFIVPKATKGFSLGKKEDKLGIRGSSTCQLIFEDCVVPKENMLGEPGFGFKI 256

Human   264 AMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLT 328
            ||||||.||||||.|||||.|.||:.||:||:.|.|||.|:.|||.||.|:|||:||:|||||||
  Fly   257 AMQTLDAGRIGIAGQALGIGQAALELAVDYAQKRQAFGKPIAKLQSIQQKIADMSLAMESARLLT 321

Human   329 WRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEG 393
            ||||.|||.|:|:.|||||||||||||||..|||.|||||||||||:|.||||||||||||||||
  Fly   322 WRAAWLKDQKQPYTKEAAMAKLAASEAATLCSHQCIQILGGMGYVTDMAAERHYRDARITEIYEG 386

Human   394 TSEIQRLVIAGHLLRSYRS 412
            |||||||||||.:|:.|.|
  Fly   387 TSEIQRLVIAGSILKEYAS 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACADS	NP_000008.1	CaiA	33..412	CDD:224871	276/378 (73%)
ACADS	NP_000008.1	SCAD_SBCAD	36..408	CDD:173847	273/371 (74%)
Arc42	NP_650840.1	CaiA	27..405	CDD:224871	276/377 (73%)
Arc42	NP_650840.1	SCAD_SBCAD	29..401	CDD:173847	273/371 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147951
Domainoid	1	1.000	228	1.000	Domainoid score	I2499
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20057
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1091
Isobase	1	0.950	-	0	Normalized mean entropy	S2260
OMA	1	1.010	-	-		QHG61069
OrthoDB	1	1.010	-	-		D350722at33208
OrthoFinder	1	1.000	-	-		FOG0000508
OrthoInspector	1	1.000	-	-		oto91250
orthoMCL	1	0.900	-	-		OOG6_101120
Panther	1	1.100	-	-	LDO	PTHR43884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5382
SonicParanoid	1	1.000	-	-		X5348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750