DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta4 and PSMB2

DIOPT Version :9

Sequence 1:	NP_001260511.1	Gene:	Prosbeta4 / 34999	FlyBaseID:	FBgn0032596	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_002785.1	Gene:	PSMB2 / 5690	HGNCID:	9539	Length:	201	Species:	Homo sapiens

Alignment Length:	195	Identity:	100/195 - (51%)
Similarity:	145/195 - (74%)	Gaps:	0/195 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METLLGIKGPDFVMLAADTTHARSIIVMKEDQNKIHKVSDSLLISTVGESGDTEQFTEFISKNIA 65
            ||.|:||:|||:|::|:|...|.:|:.||:|.:|:.|:|:.:|:..|||:|||.||.|:|.||:.
Human     1 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQ 65

  Fly    66 LYKMRNGYDLSPRESAHFTRKNLAEYLRSRTPYQVFMFVAGYDPNAGPELTFIDYLANALPVNYA 130
            ||||||||:|||..:|:|||:|||:.|||||||.|.:.:||||.:.||.|.::||||......:|
Human    66 LYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFA 130

  Fly   131 GHGYGAIFASSIYDRYWHPNITQAEAYDVFKKCIAEIQKRLVVNLKNFTVAVVDKDGVRDLEPIS 195
            .|||||....||.|||:.|.|::..|.::.:||:.|:|||.::||..|:|.::||:|:.||:.||
Human   131 AHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNIS 195

Fly 196 195
Human 196 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta4	NP_001260511.1	PRE1	1..194	CDD:223711	98/192 (51%)
Prosbeta4	NP_001260511.1	proteasome_beta_type_2	1..192	CDD:239727	97/190 (51%)
PSMB2	NP_002785.1	proteasome_beta_type_2	1..192	CDD:239727	97/190 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147326
Domainoid	1	1.000	200	1.000	Domainoid score	I3035
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2088
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3566
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53714
OrthoDB	1	1.010	-	-		D1392180at2759
OrthoFinder	1	1.000	-	-		FOG0002770
OrthoInspector	1	1.000	-	-		otm40860
orthoMCL	1	0.900	-	-		OOG6_102061
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1010
SonicParanoid	1	1.000	-	-		X1860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800