DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VhaSFD and Atp6v1h

DIOPT Version :9

Sequence 1:	NP_723992.1	Gene:	VhaSFD / 34997	FlyBaseID:	FBgn0027779	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_006237863.1	Gene:	Atp6v1h / 297797	RGDID:	1562450	Length:	483	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	262/530 - (49%)
Similarity:	350/530 - (66%)	Gaps:	64/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IDMIAATSVLQQQAADIRTRTINWASYMQSQMISEEDYKAISALDKSRAS-----FLAQNSSQVV 71
            :|....|:::..:||::|...:||.||:|.||||.||.:.|...:..|.|     .|....||..
  Rat    10 VDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRCSEEKQEMLQTEGSQCA 74

  Fly    72 KTLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHDTAGKLKQCIWGPFLNLLNRQDGFIVN 136
            ||.:||::|:||:.|:||||.::||:|||:..||.:|.|.|.:.|...|..||.:|||||.|.|:
  Rat    75 KTFINLMTHISKEQTVQYILTMVDDMLQENHQRVSIFFDYAKRSKSTAWPYFLPMLNRQDPFTVH 139

  Fly   137 MSSRILAKFACWGHETMPKSDLNFYLQFLKDQLASNGLAYLQEMAQLAKRTQTILVHTHGKDKDH 201
            |::||:||.|.||.|.|..||||:|..::|.||:|..|    ..:.:|..|.||
  Rat   140 MAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKL----RGSGVAVETGTI----------- 189

  Fly   202 HGHQYSPTLAQLQQQHELAERANESYREVGVGSDHQQQDGKCVIPNNEYIQSVARCLQMMLRVDE 266
                                .|::|                     ::|:|.||.|||:||||:|
  Rat   190 --------------------SASDS---------------------SQYVQCVAGCLQLMLRVNE 213

  Fly   267 YRFAFVGVDGISTLIRILSTRVNFQVQYQLIFCLWVLTFNPLLAAKMNKFSVIPILADILSDCAK 331
            ||||:|..||::.::.:||.:..||:|||:||.:|:|.|:|.:...:.::::||:|:|||.:..|
  Rat   214 YRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVK 278

  Fly   332 EKVTRIILAVFRNLIEKPEDSSVAKDHCIAMVQCKVLKQLSILEQRRFDDEDITADVEYLSEKLQ 396
            |||||||||.|||.:||..:....:::.:||:||||||||..|||:::|||||:.|:::|.|||.
  Rat   279 EKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLG 343

  Fly   397 NSVQDLSSFDEYATEVRSGRLEWSPVHKSAKFWRENAQRLNEKNYELLRILVHLLETSKDAIILS 461
            .|||||||||||::|::||||||||||||.|||||||.||||||||||:||..|||.|.|..:|:
  Rat   344 ESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLA 408

  Fly   462 VACFDIGEYVRHYPRGKHVLEQLGGKQIVMQHLGHEDPNVRYEALLAVQKLMVHNWEYLGKQLEK 526
            ||..|:|||||||||||.|:|||||||:||.|:.|||..|||.||||||||||||||||||||:.
  Rat   409 VAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQS 473

  Fly   527 ENENQKQGAA 536
            |   |.|.||
  Rat   474 E---QPQTAA 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VhaSFD	NP_723992.1	VATPase_H	19..518	CDD:238159	247/503 (49%)
Atp6v1h	XP_006237863.1	VATPase_H	17..465	CDD:238159	247/503 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338176
Domainoid	1	1.000	307	1.000	Domainoid score	I1301
eggNOG	1	0.900	-	-		E1_COG5231
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7139
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1211
OMA	1	1.010	-	-		QHG54625
OrthoDB	1	1.010	-	-		D352854at33208
OrthoFinder	1	1.000	-	-		FOG0004292
OrthoInspector	1	1.000	-	-		oto98707
orthoMCL	1	0.900	-	-		OOG6_101800
Panther	1	1.100	-	-	LDO	PTHR10698
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3548
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810