DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VhaSFD and atp6v1h

DIOPT Version :9

Sequence 1:	NP_723992.1	Gene:	VhaSFD / 34997	FlyBaseID:	FBgn0027779	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001278637.1	Gene:	atp6v1h / 286779	ZFINID:	ZDB-GENE-021219-2	Length:	481	Species:	Danio rerio

Alignment Length:	529	Identity:	258/529 - (48%)
Similarity:	347/529 - (65%)	Gaps:	60/529 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IDMIAATSVLQQQAADIRTRTINWASYMQSQMISEEDYKAISALD----KSRASFLAQNSSQVVK 72
            :|....|:::..:||::|...:||.||:|.||||.||.:.|...:    :.:.:.|.....|..|
Zfish     7 VDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISGEDCEFIKKFEVAGSEDKQAILTNEGHQCAK 71

  Fly    73 TLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHDTAGKLKQCIWGPFLNLLNRQDGFIVNM 137
            |.|||::|:||:.|:||||.|:||.|||:..||::|.|.|.|.|...|..||.:|||||.|.|:|
Zfish    72 TFLNLMAHISKEQTVQYILTLIDDTLQENHQRVNIFFDYAKKTKNTAWSYFLPMLNRQDLFTVHM 136

  Fly   138 SSRILAKFACWGHETMPKSDLNFYLQFLKDQLASNGLAYLQEMAQLAKRTQTILVHTHGKDKDHH 202
            ::||:||.|.||.:.|..||||:|..::|.||:|..|                           |
Zfish   137 AARIIAKLAAWGRDLMEGSDLNYYFNWIKTQLSSQKL---------------------------H 174

  Fly   203 GHQYSPTLAQLQQQHELAERANESYREVGVGSDHQQQDGKCVIPNNEYIQSVARCLQMMLRVDEY 267
            |....|                      |.|:....:       :::|:|.||.|||:||||:||
Zfish   175 GTGAEP----------------------GTGTISPSE-------SSQYVQCVAGCLQLMLRVNEY 210

  Fly   268 RFAFVGVDGISTLIRILSTRVNFQVQYQLIFCLWVLTFNPLLAAKMNKFSVIPILADILSDCAKE 332
            |||:|..||::.:..:||.:..||:|||:|||:|:|.|:|.|..::.:::|:|.|:|||.:..||
Zfish   211 RFAWVEADGVNCITAVLSNKCGFQLQYQMIFCVWLLAFSPQLCEQLRRYNVVPALSDILQESVKE 275

  Fly   333 KVTRIILAVFRNLIEKPEDSSVAKDHCIAMVQCKVLKQLSILEQRRFDDEDITADVEYLSEKLQN 397
            ||||||||.||||:||..:....:::.:||:||||||||..|:|:::||||||.|:::|.|:|..
Zfish   276 KVTRIILAAFRNLLEKSAERETRQEYALAMIQCKVLKQLENLDQQKYDDEDITDDIKFLLERLGE 340

  Fly   398 SVQDLSSFDEYATEVRSGRLEWSPVHKSAKFWRENAQRLNEKNYELLRILVHLLETSKDAIILSV 462
            |||||||||||::|::||||||||||||.|||||||.||||||||||:||..|||.|.|..:::|
Zfish   341 SVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTRLLEVSDDPQVIAV 405

  Fly   463 ACFDIGEYVRHYPRGKHVLEQLGGKQIVMQHLGHEDPNVRYEALLAVQKLMVHNWEYLGKQLEKE 527
            |..|:|||||||||||.|:|||||||:||.|:.|||..|||.||||||||||||||||||||:..
Zfish   406 AAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQLVRYNALLAVQKLMVHNWEYLGKQLQST 470

  Fly   528 NENQKQGAA 536
            .:.....||
Zfish   471 EQTTPAVAA 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VhaSFD	NP_723992.1	VATPase_H	19..518	CDD:238159	246/502 (49%)
atp6v1h	NP_001278637.1	VATPase_H	14..461	CDD:238159	246/502 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577576
Domainoid	1	1.000	309	1.000	Domainoid score	I1311
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7139
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1224
OMA	1	1.010	-	-		QHG54625
OrthoDB	1	1.010	-	-		D352854at33208
OrthoFinder	1	1.000	-	-		FOG0004292
OrthoInspector	1	1.000	-	-		oto39252
orthoMCL	1	0.900	-	-		OOG6_101800
Panther	1	1.100	-	-	LDO	PTHR10698
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1635
SonicParanoid	1	1.000	-	-		X3548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900