Protein Alignment VhaSFD and vha-18

DIOPT Version :10

• Sequence 1: NP_723992.1
• Gene: VhaSFD / 34997
• FlyBaseID: FBgn0027779
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_505171.1
• Gene: vha-18 / 179223
• WormBaseID: WBGene00018698
• Length: 451
• Species: Caenorhabditis elegans
• Alignment Length: 522
• Identity: 189/522 - (36%)
• Similarity: 287/522 - (54%)
• Gaps: 82/522 - (15%)

  Fly    10 ENIDMIAATSVLQQQAADIRTRTINWASYMQSQMISEEDYKAISALDKS-----RASFLAQNSSQ 69
            ||.|:|  .:..|::|..:|....||..:.:::||::.||..|....::     |::.|:....:
 Worm     5 ENQDLI--RTHFQKEADKVRAMKTNWGLFTRTRMIAQSDYDFIVTYQQAENEAERSTVLSVFKEK 67

  Fly    70 VVKTLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHDTAGKLKQCIWGPFLNLLNRQDGFI 134
            .|...::|:|.:|||..::|.|.|:||:|:||.:|..:|.|.|..||:..:..|:.||:|||.:|
 Worm    68 AVYAFVHLMSQISKDDYVRYTLTLIDDMLREDVTRTIIFEDVAVLLKRSPFSFFMGLLHRQDQYI 132

  Fly   135 VNMSSRILAKFACWGHETMPKSDLNFYLQFLKDQLASNGLAYLQEMAQLAKRTQTILVHTHGKDK 199
            |:::..||.|.|.:|:..:...:|::.:..||:.:
 Worm   133 VHITFSILTKMAVFGNIKLSGDELDYCMGSLKEAM------------------------------ 167

  Fly   200 DHHGHQYSPTLAQLQQQHELAERANESYREVGVGSDHQQQDGKCVIPNNEYIQSVARCLQMMLRV 264
             :.|                                          .||:||.:..||:|.:.|.
 Worm   168 -NRG------------------------------------------TNNDYIVTAVRCMQTLFRF 189

  Fly   265 DEYRFAFVGVDGISTLIRIL-STR-VNFQVQYQLIFCLWVLTFNPLLAAKMNKFSVIPILADILS 327
            |.||.:||.::|..:|...| ||| ..||:|||:|||:|:||||...|......::|..::.||.
 Worm   190 DPYRVSFVNINGYDSLTHALYSTRKCGFQIQYQIIFCMWLLTFNGHAAEVALSGNLIQTISGILG 254

  Fly   328 DCAKEKVTRIILAVFRNLIEKPEDSSVAKDHCIAMVQCKVLKQLSILEQRRFDDEDITADVEYLS 392
            :|.||||.||:::..||||...:|..:.|...:.|:|.::..:|..||.|:|.|.|:..|:.||.
 Worm   255 NCQKEKVIRIVVSTLRNLITSNQDVYMKKQAALQMIQNRIPTKLDHLENRKFTDVDLVEDMVYLQ 319

  Fly   393 EKLQNSVQDLSSFDEYATEVRSGRLEWSPVHKSAKFWRENAQRLNEKNYELLRILVHLLETSKDA 457
            .:|:..||.|:|||||..|:|.|.|.|||.||...||.|||.|||:...|||::||.:||.|.|.
 Worm   320 TELKKVVQVLTSFDEYENELRQGSLHWSPAHKCEVFWNENAHRLNDNRQELLKLLVAMLEKSNDP 384

  Fly   458 IILSVACFDIGEYVRHYPRGKHVLEQLGGKQIVMQHLGHEDPNVRYEALLAVQKLMVHNWEYLGK 522
            ::|.||..||||:||:|||||..:||||||:.:|:.|..:||||||.||||.||||::||:.||.
 Worm   385 LVLCVAAHDIGEFVRYYPRGKLKVEQLGGKEAMMRLLTVKDPNVRYHALLAAQKLMINNWKDLGL 449

  Fly   523 QL 524
            ::
 Worm   450 EI 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VhaSFD	NP_723992.1	VATPase_H	19..518	CDD:238159	182/505 (36%)
vha-18	NP_505171.1	VATPase_H	12..445	CDD:238159	182/505 (36%)