Protein Alignment grp and KSP1

DIOPT Version :10

• Sequence 1: NP_477011.1
• Gene: grp / 34993
• FlyBaseID: FBgn0261278
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_011950.1
• Gene: KSP1 / 856482
• SGDID: S000001124
• Length: 1029
• Species: Saccharomyces cerevisiae
• Alignment Length: 576
• Identity: 112/576 - (19%)
• Similarity: 206/576 - (35%)
• Gaps: 193/576 - (33%)

  Fly    26 QTLGEGAYGEVKLLINRQTGEAVAMKMV------------------------------------- 53
            :.:.||:||.|.|..:.:....||:|.:
Yeast    22 EDISEGSYGYVSLAKDVREKRLVAVKYIFKLEDDGQYDGPQDDENDCDSSDCDDDEDTKVDTDRH 86

  Fly    54 -------------------DLKKHPDAANS------VRKEVCIQKMLQ-------DKH-----IL 81
                               :|.||..:..|      :...:|::.|.:       .:|     :|
Yeast    87 ENENGNASSNNGSSREKKHNLYKHKKSLISSKVKSRLSNNICLEAMYEVDIQTKIGRHQNIAALL 151

  Fly    82 RFFGKRSQGSVEYIFLEYAAGGELFDRIEPD-VGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLK 145
            .||.       .||.:||.:||:|::.|:.| |...........||::..:.|:|.:||.|||:|
Yeast   152 DFFD-------SYIIMEYCSGGDLYEAIKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIK 209

  Fly   146 PENLLLDEHD-NVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVL---------QKAYHAQP 200
            |||:|:...| .:|::|:|:||..:..     :|:..|:..|::||:.         ::.|....
Yeast   210 PENILISGIDWTIKLTDWGLATTDKTS-----MDRNVGSERYMSPELFDSNLDIKERKEPYDCAK 269

  Fly   201 ADLWSCGVILVTMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTLA---ISLLRKLLAT 262
            .|||:.|::.:.::..:.|:...:.:...|..:..|    .:..:....|:|   ..:||..|..
Yeast   270 VDLWAMGIVFLNIVFHKNPFSIANQSDKSFCYFAAN----REALFDVFSTMAYDFFQVLRYSLTI 330

  Fly   263 SPGTR-LTL---------EKTLDHKWCNMQFADNERSYD--LVDSAAALEICSPKAKRQRLQSSA 315
            .|..| |.:         |.|||.::.|    :.:..|:  ::|......: .|.:....|.:..
Yeast   331 DPANRDLKMMRTELQNLSEYTLDDEYYN----NLDEGYEETMIDGLPPQPV-PPSSAPVSLPTPI 390

  Fly   316 HLSNGLDDSISRNYCSQPMPTMRSDDDFNVRLGSGRSKEDGGDRQTLAQEARLSYSFSQPALLDD 380
            ..||           .|.||..:.  |||....:.|.:.|
Yeast   391 SSSN-----------KQHMPEFKK--DFNFNNVNERKRSD------------------------- 417

  Fly   381 LLLATQMNQTQNASQNYFQRLVRRMTRFFVTTRWDDTIKRLVGTIERLGGYTCKFGDDGVVTVST 445
                  ::|.||.:..:|::...:..:||..                  ||.        .|:||
Yeast   418 ------VSQNQNVASGFFKKPSTQQQKFFNQ------------------GYN--------TTLST 450

  Fly   446 VDRNKLRLVFKAHIIEMDGKILVDCRLSKGCGLEFKRRFIKIKNALEDIVLKGPTT 501
            .:|.|....||.......|:  .|.:.||...:|.:::...:|.:.:.:.:..|.|
Yeast   451 HERAKSAPKFKFKKRNKYGR--TDNQFSKPVNIEDRKKSKILKKSRKPLGIPTPNT 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grp	NP_477011.1	STKc_Chk1	20..279	CDD:270971	74/350 (21%)
KSP1	NP_011950.1	STKc_Pat1_like	17..348	CDD:270895	70/341 (21%)