DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grp and SOS2

DIOPT Version :9

Sequence 1:	NP_477011.1	Gene:	grp / 34993	FlyBaseID:	FBgn0261278	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_198391.1	Gene:	SOS2 / 833502	AraportID:	AT5G35410	Length:	446	Species:	Arabidopsis thaliana

Alignment Length:	511	Identity:	143/511 - (27%)
Similarity:	235/511 - (45%)	Gaps:	105/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVD----LKKHPDAANSVRKEVCIQKMLQDKHILR 82
            :.:.:|:|||.:.:||...|..||:.||:|::.    ||..  ..:.:::|:.|.|:::..:|:|
plant    11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR--MVDQIKREISIMKIVRHPNIVR 73

  Fly    83 FFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPE 147
            .:...:..|..||.||:..||||||||.....:.:.|:::||.||:..:.:.|.:|:.|||||||
plant    74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPE 138

  Fly   148 NLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ-KAYHAQPADLWSCGVILV 211
            |||||.:.|:|:||||::.:.: :|.| ||...|||..|||||||. :.|....||:|||||||.
plant   139 NLLLDTNGNLKVSDFGLSALPQ-EGVE-LLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILF 201

  Fly   212 TMLAGELPW---DQP----STNCTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLT 269
            .:|||.||:   |.|    ..|..||:          ..||...:..  .|:.::|..:|.||:.
plant   202 VILAGYLPFSETDLPGLYRKINAAEFS----------CPPWFSAEVK--FLIHRILDPNPKTRIQ 254

  Fly   270 LEKTLDHKWCNMQF----ADNERSYDLVDSAAALEICSPKAKRQRLQSSAHLSNGLDDSISRNYC 330
            ::......|..:.:    |..|...:|.|..|..                       |.|..:|.
plant   255 IQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVF-----------------------DGIEGSYV 296

  Fly   331 SQPMPTMRSDDDFNVRLGSGRSKEDGGDRQTLAQEARLSYSFSQPALLDDLLLATQMNQTQNASQ 395
            ::.:.  |:|:        |....:..:..||:|...||..|.:.
plant   297 AENVE--RNDE--------GPLMMNAFEMITLSQGLNLSALFDRR-------------------- 331

  Fly   396 NYFQRLVRRMTRFFVTTRWDDTIKRLVGTIERLG--GYTCKFGD--DGVVTVSTVDRNKLRLVFK 456
               |..|:|.|||.......:.|..:......:|  .:|..|..  :|   :|::...:|.:|.:
plant   332 ---QDFVKRQTRFVSRREPSEIIANIEAVANSMGFKSHTRNFKTRLEG---LSSIKAGQLAVVIE 390

  Fly   457 AHIIEMDGKILVDCRLSKGCGLEFKRRFIKIKNALEDIVLKGPTTWPIAIATNSVP 512
            .:.: .....:||.|.:.|..||:.:.:.|:.:.||:|:.:         ||..:|
plant   391 IYEV-APSLFMVDVRKAAGETLEYHKFYKKLCSKLENIIWR---------ATEGIP 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grp	NP_477011.1	STKc_Chk1	20..279	CDD:270971	98/268 (37%)
grp	NP_477011.1	S_TKc	22..278	CDD:214567	98/267 (37%)
SOS2	NP_198391.1	PKc_like	10..263	CDD:419665	98/267 (37%)
SOS2	NP_198391.1	CIPK_C	311..426	CDD:213380	28/141 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I1258
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001125
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960