Protein Alignment grp and Prkaa1

DIOPT Version :10

• Sequence 1: NP_477011.1
• Gene: grp / 34993
• FlyBaseID: FBgn0261278
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_062015.2
• Gene: Prkaa1 / 65248
• RGDID: 3387
• Length: 559
• Species: Rattus norvegicus
• Alignment Length: 301
• Identity: 102/301 - (33%)
• Similarity: 157/301 - (52%)
• Gaps: 39/301 - (12%)

  Fly    22 WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKK--HPDAANSVRKEVCIQKMLQDKHILRFF 84
            :.|..|||.|.:|:||:..:..||..||:|:::.:|  ..|....:|:|:...|:.:..||::.:
  Rat    27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 91

  Fly    85 GKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENL 149
            ...|..|..::.:||.:||||||.|..:..:.:.|::|.|.|:|||::|.|:..:.||||||||:
  Rat    92 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENV 156

  Fly   150 LLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQKAYHAQP-ADLWSCGVILVTM 213
            |||.|.|.||:|||::.|.   .....|...||:..|.||||:....:|.| .|:||.||||..:
  Rat   157 LLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYAL 218

  Fly   214 LAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSK-----------LDTLAISLLRKLLATSPGTR 267
            |.|.||:              |:||  :.|.:.|           |:...||||:.:|...|..|
  Rat   219 LCGTLPF--------------DDDH--VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKR 267

  Fly   268 LTLEKTLDHKWCNMQF------ADNERSYDLVDSAAALEIC 302
            .|::...:|:|.....      .|...|..::|..|..|:|
  Rat   268 ATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVC 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grp	NP_477011.1	STKc_Chk1	20..279	CDD:270971	95/270 (35%)
Prkaa1	NP_062015.2	STKc_AMPK_alpha	24..279	CDD:270981	95/270 (35%)
		UBA_AID_AAPK1	296..360	CDD:270586	4/13 (31%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	302..381		3/7 (43%)
		AMPKA1_C	404..557	CDD:213384
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..536