DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grp and chk-1

DIOPT Version :9

Sequence 1:	NP_477011.1	Gene:	grp / 34993	FlyBaseID:	FBgn0261278	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001380036.1	Gene:	chk-1 / 3565921	WormBaseID:	WBGene00000498	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	182/519 - (35%)
Similarity:	268/519 - (51%)	Gaps:	68/519 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AATLTEAGTGPAATREFVEG-WTLAQTLGEGAYGEVKLLINRQTGE-AVAMKMVDL-KKHPDAAN 63
            ||:.|......|...:..|. :.:.|||||||:|||.|::|.:..| |.|||.::: .|..|..:
Worm     3 AASTTSTPAAAAVAPQQPESLYRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFID 67

  Fly    64 SVRKEVCIQKMLQ---DKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFT 125
            ::|||..:||.:.   ..:::|..|.|:.....|:|||||.||||||:||||.||....||.||.
Worm    68 NIRKEYLLQKRVSAVGHDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDCGMSPVFAQFYFK 132

  Fly   126 QLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPE 190
            ||:.||.::|...:.|||:|||||||.....:|||||||||::|.||:|||||..|||:||.|||
Worm   133 QLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERLLDLSCGTIPYAAPE 197

  Fly   191 VLQ-KAYHAQPADLWSCGVILVTMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTLAIS 254
            :.. |.|...|.|:||.|::|:.||.||||||:.|.....:..|..|.... :.||.|:|..|:.
Worm   198 LCAGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWISNTSLD-ERPWKKIDVRALC 261

  Fly   255 LLRKLLATSPGTRLTLEKTLDHKWCNMQFADNERSYDLVDSAAALEICSPKAKRQRLQSSAHLSN 319
            :|||::......|.|:|:.....|....|...|               :|              |
Worm   262 MLRKIVTDKTDKRATIEQIQADPWYQHNFGQVE---------------TP--------------N 297

  Fly   320 GLDDSISRNYCSQPMPTMRSDDDFNVRL-------GSGRSKEDGGDRQTLAQEARLSYSFSQPAL 377
            |           :|:...|::|: |:..       ...|..|...::.|||:  |.:.|||||..
Worm   298 G-----------RPLKRARNNDE-NITCTQQAECSAKRRHLETPNEKSTLAE--RQNASFSQPTK 348

  Fly   378 LDDLLLATQMNQTQNASQNYFQRLVRRMTRFFVTTRWDDTIKRLVGTIERLGGYTCKFG----DD 438
            .:||||...::.:|..| |..||:|.|||||.|.|....|.:::....|..|     ||    ||
Worm   349 TEDLLLTQHIDMSQTNS-NLLQRMVCRMTRFCVVTDIRSTYQKVARASEHAG-----FGVRETDD 407

  Fly   439 GVVTVSTVDRNKLRLVFKAHIIEMDGKILVDCRLSKGCGLEFKRRFIKIKNALEDIVLKGPTTW 502
            ..:.|:..:.:.:..::....|....:::||.|.|:|.|::||:.|:.::|.:.:.:......|
Worm   408 YRLLVTWREVSMMVSLYTMGDIPDKPRVMVDFRRSRGDGIQFKKMFMDVRNRMHEWICTDGNNW 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grp	NP_477011.1	STKc_Chk1	20..279	CDD:270971	120/265 (45%)
grp	NP_477011.1	S_TKc	22..278	CDD:214567	119/261 (46%)
chk-1	NP_001380036.1	STKc_Chk1	22..286	CDD:270971	119/264 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I1320
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H975
Inparanoid	1	1.050	282	1.000	Inparanoid score	I1744
Isobase	1	0.950	-	0	Normalized mean entropy	S1926
OMA	1	1.010	-	-		QHG48669
OrthoDB	1	1.010	-	-		D343319at33208
OrthoFinder	1	1.000	-	-		FOG0001125
OrthoInspector	1	1.000	-	-		otm14126
orthoMCL	1	0.900	-	-		OOG6_104812
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R198
SonicParanoid	1	1.000	-	-		X2646
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.960