Protein Alignment grp and Smok2b

DIOPT Version :10

• Sequence 1: NP_477011.1
• Gene: grp / 34993
• FlyBaseID: FBgn0261278
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_001161385.1
• Gene: Smok2b / 236574
• MGIID: 3037705
• Length: 484
• Species: Mus musculus
• Alignment Length: 493
• Identity: 124/493 - (25%)
• Similarity: 195/493 - (39%)
• Gaps: 119/493 - (24%)

  Fly    22 WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQKMLQDKHILRFFGK 86
            :.:.:|:|.|...:|.|..:|.||..||:||:  :|.....|.|..||.:..|....:|:.....
Mouse     8 YVMLETIGHGGCSKVMLARHRLTGSHVAVKMI--RKSECWCNPVMSEVELLMMADHPNIISLLQV 70

  Fly    87 RSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLL 151
            .......|:.:|...|..|:..|.....:.:.||:..|.||||.:||.|.:||.||||||:|:::
Mouse    71 IETKKKVYLIMELCEGKSLYQHIRNAGYLQEDEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMV 135

  Fly   152 DEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEV-LQKAYHAQPADLWSCGVILVTMLA 215
            ::...|||.|||:.|..:...|..|.   |||.|:.|||| |.:.|.....|:|:.||:|..|:.
Mouse   136 EKDGKVKIIDFGLGTQVKPGQKLNLF---CGTYPFSAPEVLLSRPYDGPKIDVWTLGVVLYFMVT 197

  Fly   216 GELPWDQPSTNCTEFTNWRDNDHWQLQ------------TPWSKLDTLAISLLRKLLATSPGTRL 268
            |::|:|..|                :|            .| |:|......|:..|:..:|..|.
Mouse   198 GKVPFDAAS----------------IQKLVRQILAGKYFVP-SRLSVELRDLISLLMTANPKLRP 245

  Fly   269 TLEKTLDHKW-----------C--NMQFADNE-----------RSYDLVDSAAALEICSPKAKRQ 309
            |:.:.:.|.|           |  .|....|.           ::.|:.||.           ||
Mouse   246 TVAEVMVHPWVTEGSGVFPDPCEEQMPLKPNPAIVKAMGYIGFQAQDIEDSL-----------RQ 299

  Fly   310 R-----LQSSAHLSNGLDDSISRNYCSQPM-------PTM------------RSDDDFNVRLGSG 350
            |     :.|...|...:.....|...:|||       |::            |..:..::||.:.
Mouse   300 RKFNETMASYCLLKKQILKECDRPIRAQPMNPSVTPFPSLVDTSTFHLGLRRRETEPTSLRLSAN 364

  Fly   351 RSKEDGGDRQTLAQEARLSYSFSQPALLDDLLLATQ-MNQTQNASQNYFQRLVRRMTRFFVTTR- 413
            |.....|...:..::.|    ||.|::....|..|. |:.|...:     |.|..:...|.|.:
Mouse   365 RQMSVCGRSTSKKRDRR----FSWPSVSGRPLHTTHTMDHTHTRT-----RSVPCIYSMFCTIQP 420

  Fly   414 --WDDTIK------------RLVGTIERLGGYTCKFGD 437
              .||:.:            |..|....:.|:|.|.|:
Mouse   421 NSSDDSTEGHTSASAEDKPVRSRGWPRGIKGWTRKIGN 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grp	NP_477011.1	STKc_Chk1	20..279	CDD:270971	83/280 (30%)
Smok2b	NP_001161385.1	STKc_AMPK-like	7..255	CDD:270905	82/268 (31%)
		UBA_MARK_Par1	275..314	CDD:270522	9/49 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..400		11/47 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..450		4/27 (15%)