DRSC/TRiP Functional Genomics Resources

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Protein Alignment grp and SIK2

DIOPT Version :10

Sequence 1:NP_477011.1 Gene:grp / 34993 FlyBaseID:FBgn0261278 Length:512 Species:Drosophila melanogaster
Sequence 2:NP_056006.1 Gene:SIK2 / 23235 HGNCID:21680 Length:926 Species:Homo sapiens


Alignment Length:426 Identity:123/426 - (28%)
Similarity:181/426 - (42%) Gaps:115/426 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 VEGWTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAAN--SVRKEVCIQKMLQDKHIL 81
            :||     |||:|.:..|||..:|.|...||:|::| |...||.|  .:.:||.|.|||...||:
Human    22 IEG-----TLGKGNFAVVKLGRHRITKTEVAIKIID-KSQLDAVNLEKIYREVQIMKMLDHPHII 80

  Fly    82 RFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKP 146
            :.:......|:.|:..|||..||:||.:.....:.:.||:|.|.|:||.::|.|.|.|.|||||.
Human    81 KLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKA 145

  Fly   147 ENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ-KAYHAQPADLWSCGVIL 210
            ||||||.:.|:||:|||....|:   ...||...||:.||.||||.: :.|.....|:||.||:|
Human   146 ENLLLDNNMNIKIADFGFGNFFK---SGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVL 207

  Fly   211 VTMLAGELPWDQPSTNCTE-----------FTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSP 264
            ..::.|.||:|.|:.....           :....|.:|                |:|::|...|
Human   208 YVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEH----------------LIRRMLVLDP 256

  Fly   265 GTRLTLEKTLDHKWCNMQFADNERSYDLVDSAAALEICSPKAKRQRLQSSAHLSNGLDDSISRNY 329
            ..|||:.:..:|||.            |::......:..|:.:.                     
Human   257 SKRLTIAQIKEHKWM------------LIEVPVQRPVLYPQEQE--------------------- 288

  Fly   330 CSQPMPTMRSDDDFNVRLGSGRSKEDGGDRQTLAQEARLSYS--FSQPALLDDLLLATQMNQTQN 392
             ::|     |..:||                  .|..||.:|  ..|...::.|         ||
Human   289 -NEP-----SIGEFN------------------EQVLRLMHSLGIDQQKTIESL---------QN 320

  Fly   393 ASQNYF--------QRLVRRMTRFFVTTRWDDTIKR 420
            .|.|:|        :||....:.|.|..|.|...:|
Human   321 KSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRR 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
grpNP_477011.1 STKc_Chk1 20..279 CDD:270971 98/272 (36%)
SIK2NP_056006.1 STKc_SIK 19..271 CDD:270973 98/273 (36%)
UBA_SIK2 297..341 CDD:270592 14/70 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..666
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 742..776
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..896
Blue background indicates that the domain is not in the aligned region.

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