DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment her and REST

DIOPT Version :9

Sequence 1:	NP_001260506.1	Gene:	her / 34992	FlyBaseID:	FBgn0001185	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001180437.1	Gene:	REST / 5978	HGNCID:	9966	Length:	1097	Species:	Homo sapiens

Alignment Length:	405	Identity:	82/405 - (20%)
Similarity:	149/405 - (36%)	Gaps:	120/405 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FRCSVDRCPYRTNRPYNLARHEESHIGITQSKLYGCPVCVYNTDKASNLKRHVSIKHPGCKKRPP 85
            ::|.:  |||.:::..:|.||..:|.|   .|.:.|..|.|.......:.||....|.|.|  |.
Human   304 YKCEL--CPYSSSQKTHLTRHMRTHSG---EKPFKCDQCSYVASNQHEVTRHARQVHNGPK--PL 361

  Fly    86 EAQHKDRNAKLQCLVMGCRYETNRPYDLKRHLMVHNNPEKSHRTFKCSLCTYSSDRKANLKRHHE 150
            ...|             |.|:|....:.|:|:.:|.||    |.|.|.:|.|::.:|.||:.|.:
Human   362 NCPH-------------CDYKTADRSNFKKHVELHVNP----RQFNCPVCDYAASKKCNLQYHFK 409

  Fly   151 LRHSGIEEAIQTAEELRQEMLLEKQMLKEHKLKYQIT-EKQDLKNLKLKDQKQKVQMLRDQQPKQ 214
            .:|...........:::    |:|...:|..|...|| ||.:::..|:|.         |...|:
Human   410 SKHPTCPNKTMDVSKVK----LKKTKKREADLPDNITNEKTEIEQTKIKG---------DVAGKK 461

  Fly   215 RQK-----KEQLLEDQSPVLNKQLEHGNIPLKEALVGSMKYDEESLEFVYEELQEEEQPPIITIS 274
            .:|     |..:.:::.|       ..|:.:.:....:.|           .:.|.::..:.|.|
Human   462 NEKSVKAEKRDVSKEKKP-------SNNVSVIQVTTRTRK-----------SVTEVKEMDVHTGS 508

  Fly   275 NPQ-----------------ILHGDIRDKHVIAVNVDGQLRWFQSIDPPPGAPTKLELPIKSTSI 322
            |.:                 .|||.:.|:.                     :.||.:..::|.|.
Human   509 NSEKFSKTKKSKRKLEVDSHSLHGPVNDEE---------------------SSTKKKKKVESKSK 552

  Fly   323 SVQQQMDELDDELAMSLAEEDQQDEFLVPMLSGEEPVKIKQSSLTDLAWSWSTPDAVHHISPKAE 387
            :..|::.:.|     |..||:::....:...:.::.:|.|.|..                |.|..
Human   553 NNSQEVPKGD-----SKVEENKKQNTCMKKSTKKKTLKNKSSKK----------------SSKPP 596

  Fly   388 LKKDLKAGDADTDFP 402
            .|:.::.|.|..|.|
Human   597 QKEPVEKGSAQMDPP 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
her	NP_001260506.1	C2H2 Zn finger	23..45	CDD:275368	7/21 (33%)
		C2H2 Zn finger	56..77	CDD:275368	5/20 (25%)
		C2H2 Zn finger	98..120	CDD:275368	5/21 (24%)
		C2H2 Zn finger	132..149	CDD:275370	6/16 (38%)
		tolA	140..>220	CDD:236545	19/85 (22%)
REST	NP_001180437.1	Interaction with SIN3A. /evidence=ECO:0000269\|PubMed:10734093	32..122
		Interaction with SIN3B. /evidence=ECO:0000269\|PubMed:16288918	43..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..103
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..159
		Interaction with ZFP90. /evidence=ECO:0000269\|PubMed:21284946	145..418		38/137 (28%)
		Required for binding to the neuron-restrictive silencer element. /evidence=ECO:0000250\|UniProtKB:Q8VIG1	201..212
		C2H2 Zn finger	250..270	CDD:275368
		C2H2 Zn finger	278..298	CDD:275368
		COG5048	302..>381	CDD:227381	25/96 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/21 (33%)
		zf-H2C2_2	318..343	CDD:316026	9/27 (33%)
		C2H2 Zn finger	334..355	CDD:275368	5/20 (25%)
		C2H2 Zn finger	363..383	CDD:275368	6/32 (19%)
		C2H2 Zn finger	391..407	CDD:275368	6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..642		36/229 (16%)
		FtsK	<599..>767	CDD:332908	4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	853..938
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1049
		Interaction with RCOR1. /evidence=ECO:0000269\|PubMed:10449787	1009..1087
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7055
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950