Protein Alignment Trpgamma and Trpc1

DIOPT Version :10

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_063122323.1
• Gene: Trpc1 / 89821
• RGDID: 619783
• Length: 828
• Species: Rattus norvegicus
• Alignment Length: 862
• Identity: 337/862 - (39%)
• Similarity: 496/862 - (57%)
• Gaps: 136/862 - (15%)

  Fly    36 SESSGSGHIAVQIEPARRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRM 100
            |.||.|.:..:.::..|.||         |||           ||.||.||||.::||....:::
  Rat    38 SPSSSSPNEVMALKDVREVK---------EEN-----------TLNEKLFLLACDKGDYYMVKKI 82

  Fly   101 LQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYNVDTKDALLHSISEEFVEAVEVLL 165
            |::....: :|:||||.|||.|:.:.|:||:|::::||::|...:.||||.:|..|.|.||::||
  Rat    83 LEENSSGD-LNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILL 146

  Fly   166 DHENVTFHSEGNHSWESASEDT-------------STFTPDITPLILAAHRDNYEIIKILLDRGA 217
                       ||..:.:|..|             || |.|:.|:||||||:||||:.:||.:..
  Rat   147 -----------NHRPKRSSRPTIVKLMERIQNPEYST-TMDVAPVILAAHRNNYEILTMLLKQDV 199

  Fly   218 VLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLS 282
            .||.||.|.|.|..|....::|||||||.|::.||.||||:||.|:.:||||.|||||.:|:.||
  Rat   200 ALPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELS 264

  Fly   283 FLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTG-PVYEHG---ERMHLNRLKLA 343
            .:|.||:|:|:||.:||:.||..||...|.|.|||::|||..:. |:.:.|   |||:|:|||||
  Rat   265 LVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLA 329

  Fly   344 IKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQ 408
            ||..||:||:.||.||.|.::|:..:.|:|||....:.:.::.:||.:|:.||.|::||.|..|:
  Rat   330 IKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGR 394

  Fly   409 TMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEW 473
            .:..||:|||.|.|||||||.||.|.|           ...:....|||       |.....|::
  Rat   395 IIHTPFMKFIIHGASYFTFLLLLNLYS-----------LVYNEDKKNTM-------GPALERIDY 441

  Fly   474 LILAWV-------------------SGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVA 519
            |::.|:                   ||:|||::|:||..||:::|.:..|.:.||.||||:||.|
  Rat   442 LLILWIIALGLLVYTMYLVKDLCSASGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFA 506

  Fly   520 LRVVSFFQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQ 584
            |:||:         :|.......|:.|||:.|.|::||||:.||:.|.|:|.::::.:..|||||
  Rat   507 LKVVA---------HNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQ 562

  Fly   585 VSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWY---YADLEKKRCPEVSPMSALLNMNGTNDPN 646
            :|:.:|:.|..||..:::||||:|..||.||  |   |...|:|.|      ..:.....:||
  Rat   563 ISMGQMLQDFGKFLGMFLLVLFSFTIGLTQL--YDKGYTSKEQKDC------VGIFCEQQSND-- 617

  Fly   647 ACIVWRRFSNLFETTQTLFWAVFGLIDLDSF--------ELDGIKIFTRFWGMLMFGTYSVINIV 703
                  .|.:...|...|||.:|.|..:..|        ||..      |.|.::.|||:|:.::
  Rat   618 ------TFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQS------FVGAVIVGTYNVVVVI 670

  Fly   704 VLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRR 768
            ||..||:||::.|:|||:...|.||||||:|||:|||::..|.||||||||:||:|.|.|..:.:
  Rat   671 VLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSK 735

  Fly   769 VFCSGSS---AARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAES-QGVTEDDVN 829
            ..||.:|   ..|:..||..|...|:   ||..||::|..||.||:|..::|.:| ...|.:::|
  Rat   736 WVCSHTSKGKVRRQNSLKEWRNLKQK---RDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLN 797

  Fly   830 EIKQDISAFRCELVEIL 846
            |::||:|.||.|:.::|
  Rat   798 ELRQDLSKFRNEIRDLL 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	325/814 (40%)
		ANK repeat	118..147	CDD:293786	11/28 (39%)
		ANK repeat	175..217	CDD:293786	21/54 (39%)
		TRP_CaM_bind1	865..>891	CDD:467881
Trpc1	XP_063122323.1	None