Protein Alignment Trpgamma and YVC1

DIOPT Version :9

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_014730.2
• Gene: YVC1 / 854255
• SGDID: S000005613
• Length: 675
• Species: Saccharomyces cerevisiae
• Alignment Length: 746
• Identity: 153/746 - (20%)
• Similarity: 264/746 - (35%)
• Gaps: 237/746 - (31%)

  Fly   209 IKILLDRGAVLPM---PHDVRCGCDE-----CVQSRQEDSLRHSRSRIN--AYRALASPSLIALS 263
            :|.|:|:  |:|:   |:|:.|...|     .|:...|....:.:.:.|  .|:::...||:.:.
Yeast    42 LKYLIDK--VVPIVYDPNDIVCDHSEILSPKVVKLAYEACGGNPKDKANKRKYQSVIIFSLLKVC 104

  Fly   264 SKDPILTAFELS----WELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILL---- 320
            ....||...|:.    :|.|.|:         .|:|.|        ||.....:.:|:.|.
Yeast   105 EWYSILATMEVHNAKLYETRNLA---------SQQLCK--------LLIEREETRDLQFLFMQLL 152

  Fly   321 --------NHDPTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIW-----YEGL-PG 371
                    |.:...|         ||.|:||..:.....:..|..|:.|..||     ..|| |.
Yeast   153 LRRYVINENDEDQEP---------LNALELATDMHCTTVIGSSGFQRCLKWIWRGWIVQNGLDPT 208

  Fly   372 FRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLA-- 434
            ...|:.:|..|.:|      ..|:...:.||       :.:.:::.|      |:||||.:..
Yeast   209 TFIKDDSLAEVSLI------SHFNPVRLKAP-------VYQNYLQMI------FSFLFLGLYTLV 254

  Fly   435 -----SQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVG 494
                 |:|:::|                           ..:|.:...:.:|.|..|:.:|:.:|
Yeast   255 VNGKDSERVQSF---------------------------DLLESIFYVFNTGFILDELTKLYYIG 292

  Fly   495 LQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEMIYNSHATDLPRERWDAWDPMLISEGLF 559
            ....  ..||:.:..|..:....:..|.:|...:..:  |:|       |.||.     ||..:.
Yeast   293 YAHL--SFWNLFNDTTYLIITFAMGFRAMSVTPLNAK--YSS-------EDWDK-----ISYRVL 341

  Fly   560 SAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEK 624
            |.|..|...:|:........:|.:.|.|..|:.:.:.||||..|::..|..|
Yeast   342 SCAAPFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFTQG------------- 393

  Fly   625 KRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFW 689
                    ...|.:.:|..|....|:    .||..|       |.||...|.||    :....:.
Yeast   394 --------FLGLDSADGKRDITGPIL----GNLTIT-------VLGLGSFDVFE----EFAPPYA 435

  Fly   690 GMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYF----EEGGTCP--- 747
            .:|.:|.|.::: |:|||:|||:.:.:||.:.:.||.|:....|:..:.|.    |:....|
Yeast   436 AILYYGYYFIVS-VILLNILIALYSTAYQKVIDNADDEYMALMSQKTLRYIRAPDEDVYVSPLNL 499

  Fly   748 ------PPFNIIP--TPKSIWYAI------KWMRRVFCSGSSAARREHLKTIRRKAQQASDRDFK 798
                  |.|.|:|  ..|.:.|.:      .::..:....:..|||.....::|....|::.|..
Yeast   500 IEVFMTPIFRILPPKRAKDLSYTVMTIVYSPFLLLISVKETREARRIKYNRMKRLNDDANEYDTP 564

  Fly   799 YQ-------------QIMRNLVRRYVTVE-------QRKAESQGV-------------------- 823
            :.             ...||...|...::       ||.||.:.|
Yeast   565 WDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKLQRTAEQEDVHFKVPKKWYKNVKKCSPSFE 629

  Fly   824 ------TEDDVNEIKQDISAFRCELVEILKN 848
                  ||||..|.|.::.    ||.:.::|
Yeast   630 QYDNDDTEDDAGEDKDEVK----ELTKKVEN 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	150/737 (20%)
		ANK	113..>217	CDD:238125	3/7 (43%)
		ANK repeat	118..147	CDD:293786
		ANK repeat	175..217	CDD:293786	3/7 (43%)
		TRP_2	227..286	CDD:285535	14/69 (20%)
		RRT14	<778..892	CDD:293680	22/117 (19%)
YVC1	NP_014730.2	Ion_trans	235..470	CDD:395416	67/320 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3141
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2373
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.890