DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trpgamma and TRPC6

DIOPT Version :10

Sequence 1:NP_001137830.2 Gene:Trpgamma / 34991 FlyBaseID:FBgn0032593 Length:1188 Species:Drosophila melanogaster
Sequence 2:NP_004612.2 Gene:TRPC6 / 7225 HGNCID:12338 Length:931 Species:Homo sapiens


Alignment Length:880 Identity:328/880 - (37%)
Similarity:490/880 - (55%) Gaps:137/880 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 EPARRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVN 113
            |..||:.......|..:.:|        .|::||::||.|.|.|::...|:||::...   :|||
Human    74 EKGRRLANRGPAYMFSDRST--------SLSIEEERFLDAAEYGNIPVVRKMLEECHS---LNVN 127

  Fly   114 CVDPLGRTALLMAIDNENLEMVELLINYNVDTK--DALLHSISEEFVEAVEVLLDHENVTFHSEG 176
            |||.:|:.||.:|:.||:||:.|||:.....::  ||||.:||:.:|..||.:|.|   ...:||
Human   128 CVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSH---PAFAEG 189

  Fly   177 NHSWESAS-------------EDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCG 228
            .....|.|             ||.:.|:.|:||:|||||...|||:..||.:||.:..|||..|.
Human   190 KRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCK 254

  Fly   229 CDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQ 293
            |::|.|.::.||..|||||||||:.||||:.::|||:||::||.|||.||..|:.:|.||||:|:
Human   255 CNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYK 319

  Fly   294 ELRKQCQDFATALLDHTRTSHELEILLNHD-PTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNV 357
            :|..||:||...|||..|.:.|:|.:||.| .|....:|| |.:|:|||||||...||||||.|.
Human   320 KLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHG-RPNLSRLKLAIKYEVKKFVAHPNC 383

  Fly   358 QQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSA 422
            ||.|.|||||.|.|.|::.||::.:.::.:.|..|..:|.|..||.|.:|:.||.||:||:.|:|
Human   384 QQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAA 448

  Fly   423 SYFTFLFLLML-ASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSE 486
            |:..||.||:: |:.|.|    |.....:....:..::|...:.:..:::|.||::||.|:||:|
Human   449 SFTIFLGLLVMNAADRFE----GTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAE 509

  Fly   487 VKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQK-EMIYNSHAT----------- 539
            .|::|..|.:|||.::||::||...:::.|:...|.::|:...| :.|.:::.|           
Human   510 CKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGD 574

  Fly   540 -----DLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFF 599
                 :|.|.:||..||.:|||||::.|.:.|..::.||...|...||||:||.|.|.||.||..
Human   575 NVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMV 639

  Fly   600 LYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTL 664
            ::::|..||..|:..|..||...::...                          |:.:.|:.:||
Human   640 IFIMVFVAFMIGMFNLYSYYIGAKQNEA--------------------------FTTVEESFKTL 678

  Fly   665 FWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEWK 729
            |||:|||.::.|..::....|....|.:::|.|:|..::||||:||||:|.|:|.|.:.||||||
Human   679 FWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWK 743

  Fly   730 FARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAI----KWMRRVFCSGSSAARREHLKTIRRKAQ 790
            |||:|||.||||||.|.|.|||::|:|||::|.:    ||:..:|        :.|.|..:..|:
Human   744 FARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELF--------QGHKKGFQEDAE 800

  Fly   791 Q------------------------------------ASDRDF----------KYQQIMRNLVRR 809
            .                                    .|..||          :||:||:.|::|
Human   801 MNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKR 865

  Fly   810 YVTVEQRKAESQGVTEDDVNEIKQDISAFRCELVE 844
            ||...|...||..|.|.::.|||||||:.|.||:|
Human   866 YVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE 900

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpgammaNP_001137830.2 trp 77..841 CDD:273311 320/847 (38%)
ANK repeat 118..147 CDD:293786 11/30 (37%)
ANK repeat 175..217 CDD:293786 20/54 (37%)
TRP_CaM_bind1 865..>891 CDD:467881
TRPC6NP_004612.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
trp 82..897 CDD:273311 322/867 (37%)
ANK 1 97..126 10/31 (32%)
ANK 2 132..161 11/28 (39%)
ANK repeat 132..159 CDD:293786 11/26 (42%)
ANK repeat 161..185 CDD:293786 11/26 (42%)
ANK 3 163..189 11/28 (39%)
ANK repeat 212..247 CDD:293786 17/34 (50%)
ANK 4 218..247 15/28 (54%)
Blue background indicates that the domain is not in the aligned region.

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