DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trpgamma and TRPC5

DIOPT Version :10

Sequence 1:NP_001137830.2 Gene:Trpgamma / 34991 FlyBaseID:FBgn0032593 Length:1188 Species:Drosophila melanogaster
Sequence 2:NP_036603.1 Gene:TRPC5 / 7224 HGNCID:12337 Length:973 Species:Homo sapiens


Alignment Length:951 Identity:420/951 - (44%)
Similarity:581/951 - (61%) Gaps:157/951 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 PHQEIR---QLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENL 132
            |.|.:|   :|:.|||.||.|||:||.|..::.||:|:....:|:||:|||||:|||:||:||||
Human    19 PLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENL 83

  Fly   133 EMVELLINYNVDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWESASEDT--STFTPDIT 195
            |::|||:|::|...||||::|.:|.|.|||:||.:.    ...|.....:...||  |.||||||
Human    84 EIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYR----RPSGEKQVPTLMMDTQFSEFTPDIT 144

  Fly   196 PLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLI 260
            |::||||.:||||||:|:.:...:|.||.:||.|.|||.|.:.|||||||||:|.|:||||||||
Human   145 PIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLI 209

  Fly   261 ALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPT 325
            ||||:|||||||.|.|||:.||.:|:|||.||:||.:||:.||..|||..|:|.||||:|||.. 
Human   210 ALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRD- 273

  Fly   326 GPVYEHGERM------HLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDI 384
                :|.|.:      .|.:||:|||..||:|||..|.|||||::||:|.||:|||:..::.:..
Human   274 ----DHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTC 334

  Fly   385 IRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFAD 449
            :.||.:||:.|:||:::|.|::|..::|||||||||:|||.||||:|:||||.|           
Human   335 MTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHI----------- 388

  Fly   450 SSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLY 514
                  ...:|.. :|..||.:||:||.||.|.||.|:|::||.|..||::|.||::||..||||
Human   389 ------VRTDLHV-QGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLY 446

  Fly   515 VATVALRVVSFFQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPH 579
            :||::|::|::.:      ||.   ..|||.|:.|.|.||:|.||:.:||.|||:|:.:|:.|.|
Human   447 LATISLKIVAYVK------YNG---SRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSH 502

  Fly   580 LGPLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTND 644
            |||||:||.||::||:||.|:|.|||.||.:|||||.:||                  .....::
Human   503 LGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYY------------------ETRAIDE 549

  Fly   645 PNACIVWR------RFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIV 703
            ||.|...|      .||.||||.|:|||:||||::|....:.....||.|.|..|||||:||::|
Human   550 PNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLV 614

  Fly   704 VLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRR 768
            ||||:||||||:|||||::.||:||||||:|||:|||:||||.||||||||:|||..|...|...
Human   615 VLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNN 679

  Fly   769 VFC---SGSSAARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAES-QGVTEDDVN 829
            .||   ......||.:|::...:...:..::..||:::||||:|||....|.::: :|:||::..
Human   680 TFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFK 744

  Fly   830 EIKQDISAFRCELVEILKNSGMDTNVTAGQGGGGGKKNRQKERRLMKGFNIAPPGSTGSLAPVAE 894
            |:|||||:||.|::::|                |.:|:               |.|         
Human   745 ELKQDISSFRYEVLDLL----------------GNRKH---------------PRS--------- 769

  Fly   895 FSTSLDNYDNQHEILSSTLSTLFTPNFMHKRQQSQAGSGGGGSES-----------------PTT 942
            ||||           |:.||         :|..:..||||..::|                 |..
Human   770 FSTS-----------STELS---------QRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLI 814

  Fly   943 PTAPQ--GTQGAAMTASSQVTKYNKSALKPYN---KRIAGH 978
            .|.|:  |.||.:...||....:...:||...   .:..||
Human   815 RTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGH 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpgammaNP_001137830.2 trp 77..841 CDD:273311 386/781 (49%)
ANK repeat 118..147 CDD:293786 18/28 (64%)
ANK repeat 175..217 CDD:293786 22/43 (51%)
TRP_CaM_bind1 865..>891 CDD:467881 3/25 (12%)
TRPC5NP_036603.1 trp 17..756 CDD:273311 389/790 (49%)
ANK 1. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 30..60 14/29 (48%)
ANK repeat 35..67 CDD:293786 14/31 (45%)
ANK repeat 69..98 CDD:293786 18/28 (64%)
ANK 2. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 69..97 18/27 (67%)
ANK 3. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 98..124 12/29 (41%)
ANK 4. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 141..170 16/28 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..794 14/71 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 810..837 8/26 (31%)
Essential for binding to NHERF1 PDZ domain. /evidence=ECO:0000250|UniProtKB:Q9QX29 971..973
Blue background indicates that the domain is not in the aligned region.

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