DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trpgamma and TRPC4

DIOPT Version :10

Sequence 1:NP_001137830.2 Gene:Trpgamma / 34991 FlyBaseID:FBgn0032593 Length:1188 Species:Drosophila melanogaster
Sequence 2:NP_003297.1 Gene:TRPC4 / 7223 HGNCID:12336 Length:982 Species:Homo sapiens


Alignment Length:901 Identity:427/901 - (47%)
Similarity:578/901 - (64%) Gaps:114/901 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 QLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINY 141
            :|:..||.:|.|||:||.|..::.|::|:....||:||:|||||||||:||:|||||::|||:::
Human    28 ELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSF 92

  Fly   142 NVDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWES------ASEDTSTFTPDITPLILA 200
            ||...|||||:|.:|.|.|||:||:|:        ..|.|.      ..:..|.|||||||:|||
Human    93 NVYVGDALLHAIRKEVVGAVELLLNHK--------KPSGEKQVPPILLDKQFSEFTPDITPIILA 149

  Fly   201 AHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSK 265
            ||.:||||||:|:.:|..:|.||:|||.|.|||.|...|||||||||:|.|:||||||||||||:
Human   150 AHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSE 214

  Fly   266 DPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTGPVYE 330
            ||.||||:|||||:.||.:|:|||:||:||.:||:.||..|||.||:|.||||:||:.....:.|
Human   215 DPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIE 279

  Fly   331 HGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFS 395
            ......|.|||||||.|||:|||..|.||||||.||:..||:||::.|::.|....||::||:||
Human   280 EQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFS 344

  Fly   396 LAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEEL 460
            :.|::||.|.:|..:||||||||||:|||.||||||:||||.|          |.|.:       
Human   345 VCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHI----------DRSDL------- 392

  Fly   461 PTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSF 525
             .::|..||.:||:||.||.|.||.|:||:||.|||:|::|.||::|||.||||:||::|::|:|
Human   393 -NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF 456

  Fly   526 FQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRM 590
            .:         ::...|||.||.|.|.|::|.||:.|||||||:|:.:|:.|.||||||:||.||
Human   457 VK---------YSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRM 512

  Fly   591 VMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFS 655
            ::||:||.|:|.|||.||.:|||||.:||.:.:...|.         .:......||      ||
Human   513 LLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCK---------GIRCEKQNNA------FS 562

  Fly   656 NLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLI 720
            .||||.|:|||::||||:|....:.....||.|.|..|||||:||::|||||:||||||:|||||
Human   563 TLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 627

  Fly   721 SERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSAARREHLKTI 785
            ::.||:||||||:|||:||||||||.|.|||:||:|||:||.|||:....|......:.|...||
Human   628 ADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTI 692

  Fly   786 --RRKAQQASD---RDFKYQQIMRNLVRRYVTVEQRKAES-QGVTEDDVNEIKQDISAFRCELVE 844
              |.:.::|:|   |..:||::|||||:|||....|.|:: :|:||::..|:|||||:||.|::.
Human   693 GVRTQHRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLG 757

  Fly   845 ILKNSGMDTNVTAG--------------QGGGGGKKNRQKERRLMKGFNIAPPG----------- 884
            :|:.|.:.|..:|.              ....|..|:::|...|.....:..|.           
Human   758 LLRGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNI 822

  Fly   885 STGSLAPVAE----------FSTSLDNYDNQHEILSSTLSTLFTPNFMHKRQQSQA 930
            |.||...|.|          |.|.:.|:                 ...|:|.:..|
Human   823 SNGSALVVQEPPREKQRKVNFVTDIKNF-----------------GLFHRRSKQNA 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpgammaNP_001137830.2 trp 77..841 CDD:273311 406/775 (52%)
ANK repeat 118..147 CDD:293786 19/28 (68%)
ANK repeat 175..217 CDD:293786 22/47 (47%)
TRP_CaM_bind1 865..>891 CDD:467881 7/36 (19%)
TRPC4NP_003297.1 trp 17..754 CDD:273311 406/775 (52%)
ANK 1. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN 29..60 12/30 (40%)
ANK 2. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN 71..93 15/21 (71%)
ANK 3. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN 96..118 13/21 (62%)
ANK repeat 122..167 CDD:293786 23/44 (52%)
ANK 4. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN 141..165 17/23 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..795 3/27 (11%)
PDZ-binding domain. /evidence=ECO:0000269|PubMed:12154080 980..982
Blue background indicates that the domain is not in the aligned region.

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