DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpgamma and TRPC1

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001238774.1	Gene:	TRPC1 / 7220	HGNCID:	12333	Length:	793	Species:	Homo sapiens

Alignment Length:	855	Identity:	339/855 - (39%)
Similarity:	500/855 - (58%)	Gaps:	118/855 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DAADSAEKKL-GSESSGSGHIAVQIEPARRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLA 88
            |.:.::...| .|.||.|.:..:.::..|.||         |||           ||.||.||||
Human    10 DLSGASSSSLPSSPSSSSPNEVMALKDVREVK---------EEN-----------TLNEKLFLLA 54

  Fly    89 VERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYNVDTKDALLHSI 153
            .::||....:::|::....: :|:||||.|||.|:.:.|:||||::::||::|...:.||||.:|
Human    55 CDKGDYYMVKKILEENSSGD-LNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAI 118

  Fly   154 SEEFVEAVEVLLDHENVTFHSEGNHSWESASEDT-------------STFTPDITPLILAAHRDN 205
            ..|.|.||::||           ||..:.:|..|             || |.|:.|:||||||:|
Human   119 DSEVVGAVDILL-----------NHRPKRSSRPTIVKLMERIQNPEYST-TMDVAPVILAAHRNN 171

  Fly   206 YEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILT 270
            |||:.:||.:...||.||.|.|.|..|....::|||||||.|::.||.||||:||.|:.:||||.
Human   172 YEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILR 236

  Fly   271 AFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTG-PVYEHG-- 332
            |||||.:|:.||.:|.||:|:|:||.:||:.||..||...|.|.|||::|||..:. |:.:.|
Human   237 AFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLL 301

  Fly   333 -ERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSL 396
             |||:|:|||||||..||:||:.||.||.|.::|:..:.|:|||....:.:.::.:||.:|:.||
Human   302 EERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSL 366

  Fly   397 AYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEELP 461
            .|::||.|..|:.:..||:|||.|.|||||||.||.|.|           ...:....|||
Human   367 CYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYS-----------LVYNEDKKNTM---- 416

  Fly   462 TKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFF 526
               |.....|::|::.|:.|:|||::|:||..||:::|.:..|.:.||.||||:||.||:||:
Human   417 ---GPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVA-- 476

  Fly   527 QVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMV 591
                   :|.......|:.|||:.|.|::||||:.||:.|.|:|.::::.:..|||||:|:.:|:
Human   477 -------HNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQML 534

  Fly   592 MDIMKFFFLYVLVLFAFGSGLNQLLWY---YADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRR 653
            .|..||..:::||||:|..||.||  |   |...|:|.|      ..:.....:||        .
Human   535 QDFGKFLGMFLLVLFSFTIGLTQL--YDKGYTSKEQKDC------VGIFCEQQSND--------T 583

  Fly   654 FSNLFETTQTLFWAVFGLIDLDSF--------ELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLI 710
            |.:...|...|||.:|.|..:..|        ||..      |.|.::.|||:|:.::||..||:
Human   584 FHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQS------FVGAVIVGTYNVVVVIVLTKLLV 642

  Fly   711 AMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSS 775
            ||::.|:|||:...|.||||||:|||:|||::..|.||||||||:||:|.|.|..:.:..||.:|
Human   643 AMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTS 707

  Fly   776 ---AARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAES-QGVTEDDVNEIKQDIS 836
               ..|:..||..|...|:   ||..||::|..||.||:|..::|.:| ...|.:::||::||:|
Human   708 KGKVKRQNSLKEWRNLKQK---RDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLS 769

  Fly   837 AFRCELVEIL 846
            .||.|:.::|
Human   770 KFRNEIRDLL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	325/795 (41%)
		ANK	113..>217	CDD:238125	48/116 (41%)
		ANK repeat	118..147	CDD:293786	12/28 (43%)
		ANK repeat	175..217	CDD:293786	21/54 (39%)
		TRP_2	227..286	CDD:285535	32/58 (55%)
		RRT14	<778..892	CDD:293680	27/70 (39%)
TRPC1	NP_001238774.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		6/19 (32%)
		ANK 1	46..75		10/29 (34%)
		trp	48..774	CDD:273311	323/790 (41%)
		ANK 2	83..111		12/27 (44%)
		ANK 3	112..138		13/36 (36%)
		ANK 4	158..187		15/28 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750