DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpgamma and Trpc3

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_006232344.2	Gene:	Trpc3 / 60395	RGDID:	61973	Length:	909	Species:	Rattus norvegicus

Alignment Length:	826	Identity:	323/826 - (39%)
Similarity:	480/826 - (58%)	Gaps:	100/826 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYN 142
            ||.||::||.|.|.|::...|:||::::.   :||||||.:|:.||.:|:.||:||:.|||:...
  Rat    97 LTAEEERFLDAAEYGNIPVVRKMLEESRT---LNVNCVDYMGQNALQLAVGNEHLEVTELLLKKE 158

  Fly   143 --VDTKDALLHSISEEFVEAVEVLLDHENVT-------------FHSEGNHSWESASEDTSTFTP 192
              ....||||.:||:.:|..||.:|.|....             ...:..::::   ||.:.|:|
  Rat   159 NLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYD---EDGTRFSP 220

  Fly   193 DITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASP 257
            ||||:|||||...||::.:||.:||.:..|||..|.|.:|.:.::.|:..|||||||||:.||||
  Rat   221 DITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCADCAEKQRLDAFSHSRSRINAYKGLASP 285

  Fly   258 SLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNH 322
            :.::|||:||:|||.|||.||.:|:.:|.||||:|::|..||:||...:||..|.|.|:|.:||.
  Rat   286 AYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNG 350

  Fly   323 D--PTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDII 385
            |  ...|:..||.:..|:|:|||||...||||||.|.||.|.:||||.|.|.|.:.:|::.:.::
  Rat   351 DLESVEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVL 415

  Fly   386 RIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLML-ASQRIETFIGGWFFAD 449
            .:.:..|..::.|.:||.|.:|:.:|.||:||:.|:||:..||.||:. ||.|.|    |.....
  Rat   416 VVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFE----GITTLP 476

  Fly   450 SSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLY 514
            :..:::..:::...:..:.|:.|.||:.||.|::|||.|:||..|.:||:..:|||:||...|::
  Rat   477 NITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIF 541

  Fly   515 VATVALRVVSFFQVQKEMIY-NSHATD-------LP---------RERWDAWDPMLISEGLFSAA 562
            :|....|.::|.|..|...| :||..:       ||         |::|...||.:|||||::.|
  Rat   542 IAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIA 606

  Fly   563 NIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRC 627
            .:.|..::.||...|...||||:||.|.|.||.||..|:::|..||..|:..|..||..
  Rat   607 VVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLG------ 665

  Fly   628 PEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGML 692
            .:|:|                    .|:.:.|:.:||||::|||.::.|..|.....|....|.:
  Rat   666 AKVNP--------------------AFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYV 710

  Fly   693 MFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPK 757
            ::|.|:|..:|||||:||||:|.|||.|.:.:||||||||||||:|||::|.|.||||:::|:||
  Rat   711 LYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPK 775

  Fly   758 SIWYAIKWMRRVFCSGSSAARREHL-----------KTIRRKAQQASDRDF-------------K 798
            |..|.|  ||   .:..|..||..|           |:......|::.|.|             :
  Rat   776 SFVYFI--MR---ITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTR 835

  Fly   799 YQQIMRNLVRRYVTVEQRKAESQGVTEDDVNEIKQDISAFRCELVE 844
            |||||:.|::|||...|...|:..|.|.::.|||||||:.|.||:|
  Rat   836 YQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLE 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	320/821 (39%)
		ANK	113..>217	CDD:238125	43/118 (36%)
		ANK repeat	118..147	CDD:293786	11/30 (37%)
		ANK repeat	175..217	CDD:293786	17/41 (41%)
		TRP_2	227..286	CDD:285535	31/58 (53%)
		RRT14	<778..892	CDD:293680	31/91 (34%)
Trpc3	XP_006232344.2	trp	84..878	CDD:273311	320/821 (39%)
		ANK repeat	134..165	CDD:293786	11/30 (37%)
		ANK repeat	214..249	CDD:293786	18/34 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770