DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpgamma and trpc1

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001185590.1	Gene:	trpc1 / 570841	ZFINID:	ZDB-GENE-070830-1	Length:	796	Species:	Danio rerio

Alignment Length:	851	Identity:	327/851 - (38%)
Similarity:	503/851 - (59%)	Gaps:	95/851 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAPILNKIKNGADAADSAEKKLGSESSGSGHIAVQIEPARRVKRHSIHGMMEEENTIRPHQEIRQ 77
            |:.|:..:..|.|:: |.:|.|.            ::..|.||                    .:
Zfish    10 LSVIMAALYQGTDSS-SPDKYLA------------LKDVREVK--------------------EE 41

  Fly    78 LTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYN 142
            .||:||.||||.|:||....:::|::.:..| :|:||||.|||.|:.::|:||||::::||:::.
Zfish    42 TTLDEKLFLLACEKGDYYMVKKLLEEKRHGE-LNINCVDVLGRDAVTISIENENLDILQLLLDHG 105

  Fly   143 VDTKDALLHSISEEFVEAVEVLLDH--ENVTFHSEGNHSWESASEDTSTFTPDITPLILAAHRDN 205
            ....||||.:|..|.|.||::||:|  ...:..|......:..:.:.|| |.|:.|:||||||:|
Zfish   106 CQATDALLVAIDSEVVGAVDILLNHRPRRSSKPSIAKLIQKIQNPEYST-TMDVAPVILAAHRNN 169

  Fly   206 YEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILT 270
            |||:.:||.:...||.||.|.|.|..|....::|||||||.|::.||.|||||||.|:.:||||.
Zfish   170 YEILTMLLKQDISLPRPHAVGCECTLCNAKNKKDSLRHSRFRLDIYRCLASPSLIMLTEEDPILR 234

  Fly   271 AFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPT-GPVYEHG-- 332
            |||||.:|:.||.:|.||:|:|:||.|||:.||..||.|.|.|.|||::|||..: ..|.:.|
Zfish   235 AFELSADLKELSLVEVEFRNDYEELAKQCKMFAKDLLAHARNSRELEVILNHTSSEDHVDKRGFL 299

  Fly   333 -ERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSL 396
             |||:|:|||||||..||:|||.||.||.|.::|:..:..:|||:..|:.|.::.:.:::|:.|:
Zfish   300 EERMNLSRLKLAIKYNQKEFVAQSNCQQFLNTVWFGEMASYRRKHTCLKIVSVLSVALLWPLLSI 364

  Fly   397 AYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEELP 461
            .|:|.|.|.:||.:..||||||.|||||||||.||.|.|         ..:.|...|...::
Zfish   365 CYLLGPRSRVGQVIHTPFIKFIIHSASYFTFLLLLNLYS---------LIYNDKKNMAPALQ--- 417

  Fly   462 TKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFF 526
                    ||::|::.|:.|::||:||:||..||:::|.:..|.:.||.||||:||.||::|:
Zfish   418 --------FIDYLLILWIIGMVWSDVKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKIVA-- 472

  Fly   527 QVQKEMIYNSHATDL-PRER--WDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLS 588
                   :|.::..: |.||  |||:.|.|::||||:.|.:.|.|:|.::::.:..|||||:|:.
Zfish   473 -------HNKYSKIIKPEERKEWDAFHPTLVAEGLFAFAIVLSYLRLFFMYTTSSILGPLQISMG 530

  Fly   589 RMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEK-----KRCPEVSPMSALLNMNGTNDPNAC 648
            :|:.:..||..|::|||.:|..||.||.....|..|     |.|      ..:.....:||
Zfish   531 QMLQEFGKFLGLFLLVLISFTIGLTQLYGKDQDPSKTKDDNKDC------EGIYCQQQSND---- 585

  Fly   649 IVWRRFSNLFETTQTLFWAVFGLIDLDSF--ELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIA 711
                .|.....|...|||.:|.|..::.|  .:...:....|.|.|:.|||:::.::||..||:|
Zfish   586 ----TFHTFMGTCYALFWYIFSLAHVNLFVTRISYTEELRSFVGALIVGTYNIVVVIVLTKLLVA 646

  Fly   712 MMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSA 776
            |::.|::.|:...|.||||||:|||:|||::..|.|||||::|:||::.|.:..|.:..||.:|.
Zfish   647 MLHKSFRQIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNVLPSPKTVCYLVISMSKWICSHTST 711

  Fly   777 ARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAESQG-VTEDDVNEIKQDISAFRC 840
            .:.:...::|........||..||:||..||.||:|..::|.:|.. .|.:::|:::||:|.||.
Zfish   712 GKVKRQNSLREWTNLKQKRDQNYQKIMCCLVHRYLTSTRQKMQSMDQATVENLNDLRQDLSKFRN 776

  Fly   841 ELVEIL 846
            |:.::|
Zfish   777 EMRDLL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	315/780 (40%)
		ANK	113..>217	CDD:238125	45/105 (43%)
		ANK repeat	118..147	CDD:293786	11/28 (39%)
		ANK repeat	175..217	CDD:293786	17/41 (41%)
		TRP_2	227..286	CDD:285535	33/58 (57%)
		RRT14	<778..892	CDD:293680	23/70 (33%)
trpc1	NP_001185590.1	trp	46..777	CDD:273311	313/775 (40%)
		ANK	49..177	CDD:238125	53/129 (41%)
		ANK repeat	81..110	CDD:293786	11/28 (39%)
		TRP_2	191..249	CDD:285535	33/57 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850