Protein Alignment Trpgamma and trpc6a

DIOPT Version :10

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_005161247.1
• Gene: trpc6a / 563989
• ZFINID: ZDB-GENE-040724-114
• Length: 874
• Species: Danio rerio
• Alignment Length: 857
• Identity: 326/857 - (38%)
• Similarity: 486/857 - (56%)
• Gaps: 104/857 - (12%)

  Fly    38 SSGSGH---IAVQIEPARRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRR 99
            |.|:.|   :|.|:.|..|  |.::.|.....|. .|:    .||..|::||.|.|.|::...||
Zfish    42 SYGNYHGENVARQVLPKSR--RQAVRGAAYMFNG-HPN----SLTPLEERFLDAAEYGNIPVVRR 99

  Fly   100 MLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYNVDTK--DALLHSISEEFVEAVE 162
            ||::..:   ::|||||.:|:.||.:|:.||:||:.|||:..:..::  ||||.:||:.:...||
Zfish   100 MLEELPE---LDVNCVDYMGQNALQLAVANEHLEVTELLLKKDNLSRIGDALLLAISKGYTRIVE 161

  Fly   163 VLLDHE-------------NVTFHSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEIIKILLD 214
            .:|.|:             ....|.:    :.:..||.:.|:.|:||:|||:|...|||:.|||.
Zfish   162 AILSHKAFADSRRLTASPSQAPMHDD----FFAYDEDGTRFSHDVTPVILASHCHEYEIVHILLG 222

  Fly   215 RGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELR 279
            :||.:..|||..|.||.|...::.||..||||||||||.||||:.::||::||:|.|.|||.||.
Zfish   223 KGARIEQPHDYFCTCDTCNYHQKYDSFCHSRSRINAYRGLASPAYLSLSNEDPVLAALELSNELA 287

  Fly   280 RLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTGPVYEHGERMHLNRLKLAI 344
            .|:.:|.||||||::|..||:||...|||..|::.|:|.:||.:....:...| |..|.||||||
Zfish   288 SLANIEKEFKNEYRKLSMQCKDFVVGLLDLCRSTEEVEAILNGEEDDTLELPG-RPSLIRLKLAI 351

  Fly   345 KLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQT 409
            |...||||||.|.||.|.|||||.||..|::..|::.:.::.:.:..|..::.|.:||.|.:|:.
Zfish   352 KYELKKFVAHPNCQQQLLSIWYEHLPELRQQTTAIKFLVVLGVAMGLPFLAMVYWVAPCSKMGKI 416

  Fly   410 MRKPFIKFICHSASYFTFLFLLML-ASQRIETFIGGWFFADSSGML--NTMEELPTK----RGAK 467
            ||.||:||:.|:||:..||.||:: |:.|.          |.:.:|  .|:.:.||:    :...
Zfish   417 MRGPFLKFVAHAASFTIFLGLLVMNAADRF----------DGTKLLPNMTIHDYPTQLFRMKTTP 471

  Fly   468 PTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEM 532
            .|::|.||::||.|:||:|.|::|..|.:|||.:.||::||...:::||:...|:::|:......
Zfish   472 FTWMEMLIISWVIGMIWAECKEIWSQGPREYLLEPWNLLDFGMLAIFVASFISRIMAFWHASSAQ 536

  Fly   533 IY-NSHATDL--------------PRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGP 582
            .| :.|.|||              .|..|...||.|:||||::.|.:.|..::.||...|...||
Zfish   537 RYVDEHYTDLTNVVLPFEVGYFQRARIDWLPSDPQLVSEGLYAIAVVLSFSRIAYILPANESFGP 601

  Fly   583 LQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNA 647
            ||:||.|.|.||.||..:::||..||..|:..|..||...::...
Zfish   602 LQISLGRTVKDIFKFMVIFILVFLAFMIGMFNLYSYYRGAKQNEA-------------------- 646

  Fly   648 CIVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAM 712
                  |:.:.|:.:|||||:|||.::.|..::....|....|.:::|.|:|..::||||:||||
Zfish   647 ------FTTVEESFKTLFWAIFGLSEVKSVVVNNGHKFIENIGYVLYGVYNVTVVIVLLNMLIAM 705

  Fly   713 MNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMR---------- 767
            :|:|:|.|.:.|||||||||:|||.:|||||.|.|.|||:||:|||:...:..::
Zfish   706 INNSFQEIEDDADVEWKFARAKLWFTYFEEGRTLPVPFNLIPSPKSVLSLVMGVKGLLRELSVRQ 770

  Fly   768 RVFCSGSSAARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAESQGVTEDDVNEIK 832
            :....||..:.....||.:.|....|.|   ||:||:.||:||:...|...|...|.|.::.|||
Zfish   771 KAIMKGSELSELGQSKTCQAKTLPRSSR---YQKIMKRLVKRYIIKAQNDKECDEVNEGELKEIK 832

  Fly   833 QDISAFRCELVE 844
            ||||:.|.||:|
Zfish   833 QDISSLRYELLE 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	312/810 (39%)
		ANK repeat	118..147	CDD:293786	11/30 (37%)
		ANK repeat	175..217	CDD:293786	16/41 (39%)
		TRP_CaM_bind1	865..>891	CDD:467881
trpc6a	XP_005161247.1	TRPV	65..841	CDD:454755	315/827 (38%)
		ANK repeat	76..113	CDD:293786	15/43 (35%)
		ANK repeat	115..146	CDD:293786	11/30 (37%)
		ANK repeat	194..228	CDD:293786	17/33 (52%)