DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpgamma and trpc2b

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001025337.1	Gene:	trpc2b / 562120	ZFINID:	ZDB-GENE-050712-3	Length:	1140	Species:	Danio rerio

Alignment Length:	971	Identity:	303/971 - (31%)
Similarity:	457/971 - (47%)	Gaps:	190/971 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KKF------LLAVERGDM----------AGTRRMLQKAQDTEYINVNCVDPLGRTALLMAI--DN 129
            |||      |.|:..|::          .|..|.|..::|.::          |.||.::|  .|
Zfish    15 KKFRFPPELLGAIREGNLNLVSSLLKTGDGIIRQLDDSEDRQW----------REALNLSIRLGN 69

  Fly   130 ENLEMVELLINYNVDTK---DALLHSISEEFVEAVEVLLDHENVTFHSEGN----HSWESA---- 183
            |: .|..||.....|.:   :|||.::.......|:.|||..:   ..:||    .|:..|
Zfish    70 ED-TMASLLQGVKFDFRQIHEALLVAVDTNQPRVVKRLLDRLD---QEKGNKMDVRSFSMAIFDH 130

  Fly   184 SEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRI 248
            |.|.|.|.|.:|||.||..:|.|:|:.:|..:|..:|.||.:.|.|.||...||.|.|:.|.|||
Zfish   131 SIDDSQFAPGVTPLTLACQKDLYDIVTMLNQKGHEIPWPHKISCACLECTNGRQYDLLKFSLSRI 195

  Fly   249 NAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTS 313
            |.||.:||.:.::::::|.:|:||.||.:||:||..|.|||.:|..|.:.||:||..||...|..
Zfish   196 NTYRGIASRAYLSITAEDAMLSAFRLSRDLRKLSKKEPEFKPQYLSLEQVCQEFAVELLGMCRNQ 260

  Fly   314 HELEILLN--------------HDPTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASI 364
            .|:..:||              |.    .:|.| ..:|.||:||:...||:||||...||:|:||
Zfish   261 SEVTTILNSCGDRDEDSEDELDHQ----TFEEG-IPNLARLRLAVNYNQKQFVAHPICQQVLSSI 320

  Fly   365 WYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLF 429
            |...|.|:|....:.:.:....|.:..|...|.|.:||.|.:|:.::.|.|||:.|||||..||.
Zfish   321 WCGNLSGWRGSRTSWKLLVSFGIFLTMPFLCLIYWIAPKSKLGKILKIPVIKFLLHSASYMWFLI 385

  Fly   430 LLMLASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVG 494
            .|:..|..:|.:...:.....:.:.|:..                 :.||.|..|.|.|::|..|
Zfish   386 TLLGESIAMEVYRESFATRQHTILHNSFH-----------------MVWVVGFFWFECKEVWIEG 433

  Fly   495 LQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQV---------QKEMIYNSHATDLPRERWDAWD 550
            |:.|..|.||.:|.:..|:|:|:.|||:|...:|         |.|.:|   .|:..|::|...|
Zfish   434 LRSYFLDWWNCLDVMVLSMYLASFALRLVIMLKVHFLCQLQDNQDECVY---FTETMRDQWHQED 495

  Fly   551 PMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQL 615
            |..|||.||:..::.|..:|.||...:..||.||:|:.:|:.|:|:|.|:.|::..||..|:|.:
Zfish   496 PQFISEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMMRFMFILVIIGTAFLCGINNI 560

  Fly   616 LWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTLFWAVFGL-----IDLD 675
            ...|.         :||....||                    ||...|||.:||:     :|:.
Zfish   561 YVPYI---------ISPNLGKLN--------------------ETFSFLFWTMFGMADQTYVDMP 596

  Fly   676 SFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYF 740
            :|.|      ....|.:::|.|::|.::||||:||||:.:|:|.|.:.||||||||||||::|||
Zfish   597 AFAL------AELVGRILYGIYTLIIVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYF 655

  Fly   741 EEGGTCPPPFNIIPTPKSIWYAIKW-MRRVFC---SGSSAARREHLKTIRRKAQQASDRDFKYQQ 801
            .||.|.|.||||||:||:::|.::. ::|:.|   :.:||.....|.:::.:.....:|....||
Zfish   656 REGLTMPVPFNIIPSPKAVFYLLRGIVKRICCCCFNCNSAPDYPPLTSMKDEGGSGENRIPYRQQ 720

  Fly   802 IMRNLVRRYVTVEQRKAESQGVTEDDV----NEIKQDISAFRCELVEILKN----SGMDTNVTAG 858
            ::|.||:||  :|..:.|.:.....||    .|:.:.|.....|:.:|..|    ||   |..|.
Zfish   721 VIRALVQRY--IESARREFEETKRKDVGNRITELSKVIGHLHTEMKQIHSNLFNYSG---NTKAD 780

  Fly   859 QGGGG--------GKKNRQK----ERRLMKGFNIAPP--GSTGSLAPV---AEFSTSLDNYDNQH 906
            ..|..        |.||..|    |||       |||  .:...|.|.   .|.........|..
Zfish   781 PSGDSSFLGKYILGAKNNFKDFNNERR-------APPLQETVRHLEPAETNEEPEEERKEEQNAE 838

  Fly   907 EILSSTLSTLFTPNFMHKRQQSQAGSGGGGS---ESPTTPTAPQGTQGAAMTASSQVTKYN 964
            |.:.:||               |.|:.....   |..::|.|..|.....|..:.:.|..|
Zfish   839 EQIDNTL---------------QTGNDDANKIVIEIESSPDAESGNAADKMEKAKEGTDLN 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	269/822 (33%)
		ANK	113..>217	CDD:238125	35/116 (30%)
		ANK repeat	118..147	CDD:293786	10/33 (30%)
		ANK repeat	175..217	CDD:293786	18/49 (37%)
		TRP_2	227..286	CDD:285535	27/58 (47%)
		RRT14	<778..892	CDD:293680	34/135 (25%)
trpc2b	NP_001025337.1	trp	23..762	CDD:273311	266/814 (33%)
		ANK	26..159	CDD:238125	40/146 (27%)
		ANK repeat	60..87	CDD:293786	9/27 (33%)
		ANK repeat	89..134	CDD:293786	12/47 (26%)
		ANK repeat	136..164	CDD:293786	11/27 (41%)
		TRP_2	174..233	CDD:285535	27/58 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2373
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800