DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpgamma and trpc5a

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001314676.1	Gene:	trpc5a / 557456	ZFINID:	ZDB-GENE-040812-1	Length:	1041	Species:	Danio rerio

Alignment Length:	972	Identity:	429/972 - (44%)
Similarity:	584/972 - (60%)	Gaps:	162/972 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PHQEIR---QLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENL 132
            |.|.:|   :|:.||:.||.|||:||.||.:..|::|:....|:.||||||||:|||:||:||||
Zfish    22 PLQIVRAEVELSPEERAFLSAVEKGDYAGVQHALREAEVYYNIDTNCVDPLGRSALLIAIENENL 86

  Fly   133 EMVELLINYNVDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWESASEDT--STFTPDIT 195
            |::|||:::.|:|.||||::|.:|.|.|||:||.|..    ..|.....|...|.  |.||||||
Zfish    87 EVMELLLDHGVNTGDALLYAIRKEVVGAVELLLSHRK----PSGEKQVPSLMMDAQFSEFTPDIT 147

  Fly   196 PLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLI 260
            |::||||.:||||||:|:.|...:|.||.:||.|.|||.|.:.|||||||||:|.|:||||||||
Zfish   148 PIMLAAHTNNYEIIKLLVQRKVTIPRPHQIRCDCVECVSSSEVDSLRHSRSRLNIYKALASPSLI 212

  Fly   261 ALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNH-DP 324
            ||||:|||||||.|.|||:.||.:|:||:.||:||.:||:.||..|||..|:|.|||.:||| |.
Zfish   213 ALSSEDPILTAFRLGWELKELSKVENEFRQEYEELSQQCKLFAKDLLDQARSSRELETILNHRDD 277

  Fly   325 TGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGI 389
            .....:..|...|.:||||||..||:|||..|.|||||::||:|.||:||::.|::.|....||:
Zfish   278 QSEELDPRECRDLAKLKLAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRRHWAVKLVMCFIIGL 342

  Fly   390 MFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGML 454
            :||:|||.|:|||.|::|..::|||||||||:|||.||||||:||||.|               .
Zfish   343 LFPVFSLVYLLAPKSTLGLFIKKPFIKFICHTASYLTFLFLLLLASQHI---------------A 392

  Fly   455 NTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVA 519
            .|...:   :|..||.:||:||.||.|.||:|:|::||.|..||::|.||::||..||||:||::
Zfish   393 RTNLHM---QGPPPTVVEWMILPWVLGFIWAEIKEMWDGGFNEYVHDWWNLMDFAMNSLYLATIS 454

  Fly   520 LRVVSFFQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQ 584
            |::|::.:      |||   ..|||.|:.|.|.||:|.||:.|||||||:|:.:|:.|.||||||
Zfish   455 LKIVAYVK------YNS---SRPREEWEMWHPTLIAEALFAIANIFSSLRLISLFTANSHLGPLQ 510

  Fly   585 VSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACI 649
            :||.||::||:||.|:|.|||.||.:|||||.:||                  .....::||.|.
Zfish   511 ISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYY------------------ETEAADEPNHCK 557

  Fly   650 VWR------RFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNL 708
            ..|      .||.||||.|:|||:||||::|....:.....||.|.|..|||||:||::|||||:
Zfish   558 GIRCERQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNM 622

  Fly   709 LIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSG 773
            ||||||:|||||::.||:||||||:|||:|||:||||.||||||||:|||.||..:|:....|..
Zfish   623 LIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFWYLCRWVHGRLCGS 687

  Fly   774 SSAA------RREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAE-SQGVTEDDVNEI 831
            .:|.      :.|:||....|......::..||:::|:||:|||....|.|: |:|:||::..|:
Zfish   688 ETAPPEEDTHKHENLKEFTEKHADRLIQNQHYQEVIRSLVKRYVASMIRSAKTSEGLTEENFKEL 752

  Fly   832 KQDISAFRCELVEILKN------------------------------------------------ 848
            |||||:||.|::::|.|
Zfish   753 KQDISSFRYEVLDLLGNRKPPRRNYSSSSEATLRDEVSDDGEARHHSDGSSIGAKGVSFKTITPS 817

  Fly   849 ------SGMDTNVTAGQGGGGGKKNRQKERRLMKGFNIAPPGSTGSLAPV------------AEF 895
                  |.:..:::..:..|..::.:.|...|.|  |.:|..|..|:||.            :.|
Zfish   818 DPSYGVSALFHSISGMEAAGTTREGKPKINGLRK--NPSPSSSLSSVAPARAPALSRTWRRFSRF 880

  Fly   896 STSLDNYDNQHEILSSTLSTLFTPNFMHKRQQSQAGSGGGGSESPTTPTAPQGTQGAAMTAS 957
            |:|..|...:..:|.|.:                      ||..|    .|.|...|..|.|
Zfish   881 SSSKKNSFRRLGLLFSRM----------------------GSHLP----QPTGVTAATYTIS 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	398/779 (51%)
		ANK	113..>217	CDD:238125	59/105 (56%)
		ANK repeat	118..147	CDD:293786	18/28 (64%)
		ANK repeat	175..217	CDD:293786	23/43 (53%)
		TRP_2	227..286	CDD:285535	42/58 (72%)
		RRT14	<778..892	CDD:293680	39/168 (23%)
trpc5a	NP_001314676.1	trp	20..762	CDD:273311	401/788 (51%)
		ANK	38..165	CDD:238125	69/130 (53%)
		ANK repeat	73..101	CDD:293786	17/27 (63%)
		ANK repeat	102..139	CDD:293786	15/40 (38%)
		TRP_2	179..238	CDD:285535	42/58 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581916
Domainoid	1	1.000	270	1.000	Domainoid score	I1782
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm6331
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900