Protein Alignment Trpgamma and Trpc7

DIOPT Version :10

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_006517325.1
• Gene: Trpc7 / 26946
• MGIID: 1349470
• Length: 906
• Species: Mus musculus
• Alignment Length: 859
• Identity: 310/859 - (36%)
• Similarity: 453/859 - (52%)
• Gaps: 179/859 - (20%)

  Fly    55 KRHSIHG---MMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVD 116
            :|.:|.|   |..|:.|        .||.||::||.:.|.|::...|:||   ::::.:|.||||
Mouse   121 RRQAIRGPAYMFNEKGT--------SLTPEEERFLDSAEYGNIPVVRKML---EESKTLNFNCVD 174

  Fly   117 PLGRTALLMAIDNENLEMVELLINYN--VDTKDALLHSISEEFVEAVEVLLDH------ENVTF- 172
            .:|:.||.:|:.||:||:.|||:...  ....||||.:||:.:|..||.:|.|      :.:|.
Mouse   175 YMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLS 239

  Fly   173 ---HSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQ 234
               ....:..:.:..||.:.|:.||||:|||||...|||:.|||.:||.:..|||..|.|:||.:
Mouse   240 PLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTE 304

  Fly   235 SRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQC 299
            .:::||..|||||:|||:.|||.:.::|||:||:|||.|||.||.||:.:|.||||:|::|..||
Mouse   305 KQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQC 369

  Fly   300 QDFATALLDHTRTSHELEILLNHDPTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASI 364
            :||...:||..|.:.|:|.:||.|....|:....|..|:|:|||||...||
Mouse   370 KDFVVGVLDLCRDTEEVEAILNGDVNLQVWSDHHRPSLSRIKLAIKYEVKK-------------- 420

  Fly   365 WYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLF 429
                                                     :|||:|.||:||:.|:.|:..||.
Mouse   421 -----------------------------------------LGQTLRSPFMKFVAHAVSFTIFLG 444

  Fly   430 LLML-ASQRIETFIGGWFFADSSGMLNTMEELPTKR---------GAKPTFIEW---LILAWVSG 481
            ||:: ||.|.|                .::.||.:.         ..|.|...|   ||:.||.|
Mouse   445 LLVVNASDRFE----------------GVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLG 493

  Fly   482 LIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEMIY--------NSHA 538
            :||||.|::|:.|.:||:..:||::||...|::||:...|.::|.:..:..:|        ..|.
Mouse   494 MIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQYVQDVTLHN 558

  Fly   539 TDLP---------RERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDI 594
            ..||         |::|...||.:|||||::.|.:.|..::.||...|...||||:||.|.|.||
Mouse   559 VSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDI 623

  Fly   595 MKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFE 659
            .||..::::|..||..|:..|..||      |..:.:|                    .|:.:.|
Mouse   624 FKFMVIFIMVFVAFMIGMFNLYSYY------RGAKYNP--------------------AFTTVEE 662

  Fly   660 TTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERA 724
            :.:||||::|||.::.|..|.....|....|.:::|.|:|..:|||||:||||:|:|||.|.|.|
Mouse   663 SFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDA 727

  Fly   725 DVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFC----SGSSAARREH---- 781
            ||||||||:|||:|||:||.|.|.|||::|:|||.:|.|  ||...|    ..|.|.|.|:
Mouse   728 DVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLI--MRIKMCLIELCQSKAKRCENDLEM 790

  Fly   782 --LKTIRRKAQ-QASDRD-------------FKYQQIMRNLVRRYVTVEQRKAESQGVTEDDVNE 830
              |.:..||.: ||..|:             .:||:||:.|::|||...|...|:..|.|.::.|
Mouse   791 GMLNSKFRKTRYQAGMRNSENLTANSTFSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKE 855

  Fly   831 IKQDISAFRCELVE 844
            ||||||:.|.||:|
Mouse   856 IKQDISSLRYELLE 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	301/829 (36%)
		ANK repeat	118..147	CDD:293786	11/30 (37%)
		ANK repeat	175..217	CDD:293786	18/41 (44%)
		TRP_CaM_bind1	865..>891	CDD:467881
Trpc7	XP_006517325.1	trp	126..866	CDD:273311	305/849 (36%)
		ANK repeat	176..207	CDD:293786	11/30 (37%)
		ANK repeat	208..254	CDD:293786	11/45 (24%)
		ANK repeat	256..291	CDD:293786	19/34 (56%)