DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpgamma and Trpc6

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_006509912.1	Gene:	Trpc6 / 22068	MGIID:	109523	Length:	949	Species:	Mus musculus

Alignment Length:	873	Identity:	325/873 - (37%)
Similarity:	489/873 - (56%)	Gaps:	123/873 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EPARRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVN 113
            |..||:.......|..:.:|        .|::||::||.|.|.|::...|:||::...   :|||
Mouse    92 EKGRRLANRGPAYMFNDHST--------SLSIEEERFLDAAEYGNIPVVRKMLEECHS---LNVN 145

  Fly   114 CVDPLGRTALLMAIDNENLEMVELLINYNVDTK--DALLHSISEEFVEAVEVLLDHENVTFHSEG 176
            |||.:|:.||.:|:.||:||:.|||:.....::  ||||.:||:.:|..||.:|:|   ...:||
Mouse   146 CVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNH---PAFAEG 207

  Fly   177 NHSWESAS-------------EDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCG 228
            .....|.|             ||.:.|:.|:||:|||||...|||:..||.:||.:..|||..|.
Mouse   208 KRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCK 272

  Fly   229 CDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQ 293
            |.||.|.::.||..|||||||||:.||||:.::|||:||::||.|||.||..|:.:|.||||:|:
Mouse   273 CTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYR 337

  Fly   294 ELRKQCQDFATALLDHTRTSHELEILLNHDPTGPVYEHGE--RMHLNRLKLAIKLRQKKFVAHSN 356
            :|..||:||...|||..|.:.|:|.:||.|  ....:.|:  |.:|:|||||||...||||||.|
Mouse   338 KLSMQCKDFVVGLLDLCRNTEEVEAILNGD--AETRQPGDFGRPNLSRLKLAIKYEVKKFVAHPN 400

  Fly   357 VQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHS 421
            .||.|.|||||.|.|.|::.||::.:.::.:.|..|..:|.|..||.|.:|:.:|.||:||:.|:
Mouse   401 CQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHA 465

  Fly   422 ASYFTFLFLLML-ASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWS 485
            ||:..||.||:: |:.|.|    |.....:....:...:|...:.:..:::|.||::||.|:||:
Mouse   466 ASFTIFLGLLVMNAADRFE----GTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWA 526

  Fly   486 EVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQK-EMIYNSHAT---------- 539
            |.|::|..|.:|||.::||::||...:::.|:...|.::|:...| :.|.:::.|
Mouse   527 ECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLG 591

  Fly   540 ------DLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFF 598
                  :|.|.:||..||.:|||||::.|.:.|..::.||...|...||||:||.|.|.||.||.
Mouse   592 DNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFM 656

  Fly   599 FLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQT 663
            .::::|..||..|:..|..||...::...                          |:.:.|:.:|
Mouse   657 VIFIMVFVAFMIGMFNLYSYYIGAKQNEA--------------------------FTTVEESFKT 695

  Fly   664 LFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEW 728
            ||||:|||.::.|..::....|....|.:::|.|:|..::||||:||||:|.|:|.|.:.|||||
Mouse   696 LFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEW 760

  Fly   729 KFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAI----KWM-------RRVFCSGSSAARREHL 782
            ||||:|||.||||||.|.|.|||::|:|||:.|.:    |||       ::.|...:...:|...
Mouse   761 KFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEE 825

  Fly   783 KTI---------------------RRKAQQASDRDF----------KYQQIMRNLVRRYVTVEQR 816
            |..                     .:::...|..|:          :||:||:.|::|||...|.
Mouse   826 KKFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQI 890

  Fly   817 KAESQGVTEDDVNEIKQDISAFRCELVE 844
            ..||..|.|.::.|||||||:.|.||:|
Mouse   891 DKESDEVNEGELKEIKQDISSLRYELLE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	317/840 (38%)
		ANK	113..>217	CDD:238125	46/118 (39%)
		ANK repeat	118..147	CDD:293786	11/30 (37%)
		ANK repeat	175..217	CDD:293786	20/54 (37%)
		TRP_2	227..286	CDD:285535	33/58 (57%)
		RRT14	<778..892	CDD:293680	28/98 (29%)
Trpc6	XP_006509912.1	trp	100..915	CDD:273311	319/860 (37%)
		ANK repeat	150..177	CDD:293786	11/26 (42%)
		ANK repeat	179..203	CDD:293786	11/26 (42%)
		ANK repeat	230..265	CDD:293786	17/34 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770