DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpgamma and Trpc3

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_062383.2	Gene:	Trpc3 / 22065	MGIID:	109526	Length:	910	Species:	Mus musculus

Alignment Length:	925	Identity:	340/925 - (36%)
Similarity:	508/925 - (54%)	Gaps:	139/925 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PARRKSVLAPILNKIKNG-ADAADSAEKKLGSESSGSGHIAVQIEP---------------ARRV 54
            |||   |..|...:.::| |:..:|..::.|......|     :||               ....
Mouse    11 PAR---VTLPAPEEEEDGEAEGGESQRRRRGWRGVNGG-----LEPPCPRAPPSPGPDASSEGSP 67

  Fly    55 KRHSIHGMMEEENTIRPHQEIR-----------QLTLEEKKFLLAVERGDMAGTRRMLQKAQDTE 108
            .|....||.::..    .|.:|           .||.||::||.|.|.|::...|:||::::.
Mouse    68 SRWRTAGMRDKGR----RQAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEESRT-- 126

  Fly   109 YINVNCVDPLGRTALLMAIDNENLEMVELLINYN--VDTKDALLHSISEEFVEAVEVLLDHENVT 171
             :||||||.:|:.||.:|:.||:||:.|||:...  ....||||.:||:.:|..||.:|.|....
Mouse   127 -LNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFA 190

  Fly   172 -------------FHSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPH 223
                         ...:..::::   ||.:.|:|||||:|||||...||::.:||.:||.:..||
Mouse   191 ASRRLTLSPCEQELRDDDFYAYD---EDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPH 252

  Fly   224 DVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEF 288
            |..|.|.:|.:.::.|:..|||||||||:.||||:.::|||:||:|||.|||.||.:|:.:|.||
Mouse   253 DYFCRCSDCAEKQRLDAFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEF 317

  Fly   289 KNEYQELRKQCQDFATALLDHTRTSHELEILLNHD--PTGPVYEHGERMHLNRLKLAIKLRQKKF 351
            ||:|::|..||:||...:||..|.|.|:|.:||.|  ...|:..||.:..|:|:|||||...|||
Mouse   318 KNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLERHGHKASLSRVKLAIKYEVKKF 382

  Fly   352 VAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIK 416
            |||.|.||.|.:||||.|.|.|.:.:|::.:.::.:.:..|..::.|.:||.|.:|:.:|.||:|
Mouse   383 VAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMK 447

  Fly   417 FICHSASYFTFLFLLML-ASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVS 480
            |:.|:||:..||.||:. ||.|.|    |.....:..:::..:::...:..:.|:.|.||:.||.
Mouse   448 FVAHAASFIIFLGLLVFNASDRFE----GITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVL 508

  Fly   481 GLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEMIY-NSHATD---- 540
            |::|||.|:||..|.:||:..:|||:||...|:::|....|.::|.|..|...| :||..:
Mouse   509 GMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLS 573

  Fly   541 ---LP---------RERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMD 593
               ||         |::|...||.:|||||::.|.:.|..::.||...|...||||:||.|.|.|
Mouse   574 EVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKD 638

  Fly   594 IMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLF 658
            |.||..|:::|..||..|:..|..||..      .:|:|                    .|:.:.
Mouse   639 IFKFMVLFIMVFLAFMIGMFILYSYYLG------AKVNP--------------------AFTTVE 677

  Fly   659 ETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISER 723
            |:.:||||::|||.::.|..|.....|....|.:::|.|:|..:|||||:||||:|.|||.|.:.
Mouse   678 ESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDD 742

  Fly   724 ADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSAARREHL------ 782
            :||||||||||||:|||::|.|.||||:::|:|||..|.|  ||   .:..|..||..|
Mouse   743 SDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI--MR---ITNFSKCRRRRLQKDLEL 802

  Fly   783 -----KTIRRKAQQASDRDF-------------KYQQIMRNLVRRYVTVEQRKAESQGVTEDDVN 829
                 |:......|::.|.|             :|||||:.|::|||...|...|:..|.|.::.
Mouse   803 GMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELK 867

  Fly   830 EIKQDISAFRCELVE 844
            |||||||:.|.||:|
Mouse   868 EIKQDISSLRYELLE 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	320/822 (39%)
		ANK	113..>217	CDD:238125	43/118 (36%)
		ANK repeat	118..147	CDD:293786	11/30 (37%)
		ANK repeat	175..217	CDD:293786	17/41 (41%)
		TRP_2	227..286	CDD:285535	31/58 (53%)
		RRT14	<778..892	CDD:293680	31/91 (34%)
Trpc3	NP_062383.2	trp	85..879	CDD:273311	321/834 (38%)
		ANK	108..242	CDD:238125	49/139 (35%)
		ANK repeat	135..166	CDD:293786	11/30 (37%)
		ANK repeat	215..250	CDD:293786	18/34 (53%)
		TRP_2	256..315	CDD:285535	31/58 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770