DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpgamma and Trpc2

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001103367.1	Gene:	Trpc2 / 22064	MGIID:	109527	Length:	890	Species:	Mus musculus

Alignment Length:	964	Identity:	295/964 - (30%)
Similarity:	449/964 - (46%)	Gaps:	197/964 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SESSGSGHIAVQIEPARRVKRHSIHGMMEEEN-TIR-PHQEIRQLTLEEKKF---------LLAV 89
            |::||:|...    |.|.|:........|..| .|| .|:.|..:.|...||         |:||
Mouse    44 SDASGAGPGG----PLRNVEESEDRSWREALNLAIRLGHEVITDVLLANVKFDFRQIHEALLVAV 104

  Fly    90 ERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYNVDTKDALLHSIS 154
            :....|..||:|.:.:..:          ||                     .||||     |.|
Mouse   105 DTNQPAVVRRLLARLEREK----------GR---------------------KVDTK-----SFS 133

  Fly   155 EEFVEAVEVLLDHENVTFHSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVL 219
            ..|.:                       :|.|.|.|.|.:|||.||..:|.|||.::|:|:|..:
Mouse   134 LAFFD-----------------------SSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTI 175

  Fly   220 PMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFL 284
            ..||.|.|.|.||..:|:.|.|:.|.||||.||.:||.:.::|:|:|.:|.||:||.|||||:..
Mouse   176 ARPHPVSCACLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASEDAMLAAFQLSRELRRLARK 240

  Fly   285 EHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNH-----------DPTGPVYEHGERMHLN 338
            |.|||.:|..|...|||:...||...|...|:..:||.           :..|..:|.| ..:|.
Mouse   241 EPEFKPQYIALESLCQDYGFELLGMCRNQSEVTAVLNDLGEDSETEPEAEGLGQAFEEG-IPNLA 304

  Fly   339 RLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPY 403
            ||:||:...||:||||...||:|:|||...|.|:|......:......|.:..|...:.|.|||.
Mouse   305 RLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGSTTIWKLFVAFLIFLTMPFLCIGYWLAPK 369

  Fly   404 SSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKP 468
            |.:|:.::.|.:||:.|||||..||..|:..|..:||                  :|.|.:|...
Mouse   370 SQLGRLLKIPVLKFLLHSASYLWFLIFLLGESLVMET------------------QLSTFKGRSQ 416

  Fly   469 TFIEW-LILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRV----VSFFQV 528
            :..|. |.:.||:|.:|.|.|::|..||:.||.|.||.:|.|..|||:|:.|||:    :::...
Mouse   417 SVWETSLHMIWVTGFLWFECKEVWIEGLRSYLLDWWNFLDVVILSLYLASFALRLLLAGLAYMHC 481

  Fly   529 Q--KEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMV 591
            :  .:.....:.|...|..|...||..::|.||:..::.|..:|.||...:..||.||:|:.:|:
Mouse   482 RDASDSTTCRYFTTAERSEWRTEDPQFLAEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMI 546

  Fly   592 MDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSN 656
            .|:::|.|:.:::|.||..|||.:...|.:.||                             ..|
Mouse   547 DDMIRFMFILMIILTAFLCGLNNIYVPYQESEK-----------------------------LGN 582

  Fly   657 LFETTQTLFWAVFGL-----IDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHS 716
            ..||.|.|||.:||:     :|:..|      :...|.|..|:|.::::.::||||:||||:.:|
Mouse   583 FNETFQFLFWTMFGMEEHTVVDMPQF------LVPEFVGRAMYGIFTIVMVIVLLNMLIAMITNS 641

  Fly   717 YQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSA--ARR 779
            :|.|.:.||||||||||||::|||.||.|.|.||||:|:||:.:|.::.:.|..|.|||.  |::
Mouse   642 FQKIEDDADVEWKFARSKLYLSYFREGLTLPVPFNILPSPKAAFYLVRRIFRFLCCGSSCCKAKK 706

  Fly   780 EHLKTI-------RRKAQQASDRDFKYQ-QIMRNLVRRYVTVEQRKAESQGVTE--DDVNEIKQD 834
            .....|       .|...........|: ::::.||:||:...:|:.|.....:  :.:.|:.:.
Mouse   707 SDYPPIGTFTNPGARAGSAGEGERVSYRLRVIKALVQRYIETARREFEETRRKDLGNRLTELTKT 771

  Fly   835 ISAFRCELVEILKNSGMDTNVTAGQGGG-----GGKKNRQKERRLMKGF-NIAPPGSTG----SL 889
            :|..:.|:..:.||        ...||.     |.....:...|:...| |:.||.|..    ::
Mouse   772 VSRLQSEVASVQKN--------LAAGGAPRPPDGASILSRYITRVRNSFQNLGPPTSDTPAELTM 828

  Fly   890 APVAEFSTSL-DNYDNQHEI---------LSSTLSTLFTPNFMHKRQQSQAGSG 933
            ..:.|...|| |..|...|.         .||:...|     :|:.|::: |||
Mouse   829 PGIVETEVSLGDGLDGTGEAGAPAPGEPGSSSSAHVL-----VHREQEAE-GSG 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	256/807 (32%)
		ANK	113..>217	CDD:238125	25/103 (24%)
		ANK repeat	118..147	CDD:293786	5/28 (18%)
		ANK repeat	175..217	CDD:293786	16/41 (39%)
		TRP_2	227..286	CDD:285535	29/58 (50%)
		RRT14	<778..892	CDD:293680	23/133 (17%)
Trpc2	NP_001103367.1	trp	23..761	CDD:273311	267/833 (32%)
		ANK	63..>172	CDD:238125	41/167 (25%)
		ANK repeat	93..138	CDD:293786	16/80 (20%)
		ANK repeat	140..173	CDD:293786	16/32 (50%)
		TRP_2	183..242	CDD:285535	29/58 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810